DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tl and TLR1

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_003254.2 Gene:TLR1 / 7096 HGNCID:11847 Length:786 Species:Homo sapiens


Alignment Length:815 Identity:188/815 - (23%)
Similarity:296/815 - (36%) Gaps:259/815 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   371 LDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGI-SGDIFSNLGNLVTLVMSRNRLRTIDSRAF 434
            :|.|.|.|.|:|..|...|   |.|.:..|.::.: :.||.| |..|..|::|.||::.:|...|
Human    29 VDRSKNGLIHVPKDLSQKT---TILNISQNYISELWTSDILS-LSKLRILIISHNRIQYLDISVF 89

  Fly   435 VSTNGLRHLHLDHN--------------DIDLQQPLLDIMLQTQINSPFGYMH-----GLLTLNL 480
            .....|.:|.|.||              .:||.....|.:   .|...||.|.     ||.|.:|
Human    90 KFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDAL---PICKEFGNMSQLKFLGLSTTHL 151

  Fly   481 RNNSIIFVYNDWKNTMLQLRELDLSYNNISS----LGY--------EDLAFLSQNRLHVNMTHNK 533
            ..:|:                |.:::.|||.    ||.        |.|...:...||:....||
Human   152 EKSSV----------------LPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNK 200

  Fly   534 IRRIALPEDVHLGEGYNNNLVHV-----------------DLNDNPLVCDCTI-----LW--FIQ 574
            .....|  ||.:....|..|.::                 .|..||.:.:.|:     .|  ||:
Human   201 EFHFIL--DVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIR 263

  Fly   575 LVRGVHKPQYSRQFKLRTDRLVCSQPNV------------LEGTPVRQIE-----------PQT- 615
            ::          |....|.....|..||            ..||.::.:.           ||: 
Human   264 IL----------QLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSY 318

  Fly   616 ----------------------LICP--------LDFSDDPRERKCPRGCNCHVRTYDKALVINC 650
                                  ::||        ||||::               .....:..||
Human   319 IYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNN---------------LLTDTVFENC 368

  Fly   651 HSGNLTH----VPRLPNLHKNMQLMELHLENNTLLRLP-SANTPGYE----------SVTSLHLA 700
              |:||.    :.::..|.:..::.|:..:..:|.:|. |.|:..|:          |:.||:::
Human   369 --GHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMS 431

  Fly   701 GNNLTSIDVDQLPTNLTHLDISWNH-------------LQMLNA-----------------TVL- 734
            .|.||......||..:..||:..|.             ||.||.                 :|| 
Human   432 SNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLI 496

  Fly   735 -----------GFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERI------GDRNEMMCV 782
                       .|.....|.||:|...||:.|.|.....:    .|.:::      |..:...|.
Human   497 IDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFV----KNIDQVSSEVLEGWPDSYKCD 557

  Fly   783 NAE-------MPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKF-----QTEIK 835
            ..|       ....|.|||.|........|...|.:.:.:|.|.:......|.:.     ||..:
Human   558 YPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRR 622

  Fly   836 IWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVG 900
                |.|:.|     |:|.::.:|.||||||..|..::::.|:|.||  .:..|:|:|||:::.|
Human   623 ----ARNIPL-----EELQRNLQFHAFISYSGHDSFWVKNELLPNLE--KEGMQICLHERNFVPG 676

  Fly   901 GHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIG--DVEK 963
            ..|.|||:..:..|.::|.|||.||::|||...|...||.:..:||.:.:|:|:...|.  .:..
Human   677 KSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPS 741

  Fly   964 LDEELKAYLKMNTYLKWGDP-----WFWDKLRFAL 993
            ...:||:.:...|||:|...     .||..||.|:
Human   742 SYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAI 776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697
leucine-rich repeat 176..198 CDD:275380
leucine-rich repeat 199..222 CDD:275380
LRR 222..576 CDD:443914 63/260 (24%)
leucine-rich repeat 223..270 CDD:275380
leucine-rich repeat 271..294 CDD:275380
leucine-rich repeat 295..320 CDD:275380
leucine-rich repeat 321..343 CDD:275380
leucine-rich repeat 344..367 CDD:275380
leucine-rich repeat 368..391 CDD:275380 8/19 (42%)
leucine-rich repeat 392..415 CDD:275380 7/23 (30%)
leucine-rich repeat 416..439 CDD:275380 7/22 (32%)
leucine-rich repeat 440..474 CDD:275380 12/52 (23%)
leucine-rich repeat 475..498 CDD:275380 4/22 (18%)
leucine-rich repeat 499..520 CDD:275380 8/32 (25%)
leucine-rich repeat 523..552 CDD:275380 8/28 (29%)
LRRCT 561..619 CDD:214507 15/110 (14%)
LRRNT 631..667 CDD:214470 6/39 (15%)
PPP1R42 <660..752 CDD:455733 29/144 (20%)
leucine-rich repeat 664..693 CDD:275380 7/39 (18%)
leucine-rich repeat 694..715 CDD:275380 7/20 (35%)
leucine-rich repeat 716..737 CDD:275380 9/62 (15%)
LRRCT 751..800 CDD:214507 13/61 (21%)
TIR 858..996 CDD:214587 51/143 (36%)
TLR1NP_003254.2 LRR <29..>152 CDD:443914 37/129 (29%)
leucine-rich repeat 47..70 CDD:275378 8/26 (31%)
LRR 1 54..77 7/23 (30%)
leucine-rich repeat 71..94 CDD:275378 7/22 (32%)
LRR 2 78..101 6/22 (27%)
leucine-rich repeat 95..115 CDD:275378 5/19 (26%)
LRR 3 102..125 4/22 (18%)
leucine-rich repeat 116..140 CDD:275378 7/26 (27%)
LRR 4 126..150 8/26 (31%)
leucine-rich repeat 141..152 CDD:275378 3/10 (30%)
LRR 5 151..175 8/39 (21%)
LRR 6 176..199 4/22 (18%)
LRR 7 200..223 6/24 (25%)
LRR 215..>526 CDD:443914 59/337 (18%)
LRR 8 224..250 3/25 (12%)
LRR 9 251..278 5/36 (14%)
LRR 10 279..308 4/28 (14%)
LRR 11 309..337 2/27 (7%)
Interaction with bacterial lipopeptide 313..316 0/2 (0%)
LRR 12 338..361 6/37 (16%)
leucine-rich repeat 352..373 CDD:275380 8/37 (22%)
LRR 13 362..388 6/27 (22%)
leucine-rich repeat 374..399 CDD:275380 2/24 (8%)
LRR 14 389..414 6/24 (25%)
leucine-rich repeat 400..424 CDD:275380 5/23 (22%)
LRR 15 415..437 5/21 (24%)
leucine-rich repeat 425..446 CDD:275380 7/20 (35%)
LRR 16 438..457 5/18 (28%)
leucine-rich repeat 447..469 CDD:275380 3/21 (14%)
LRR 17 458..478 4/19 (21%)
leucine-rich repeat 470..492 CDD:275380 4/21 (19%)
LRR 18 479..500 2/20 (10%)
leucine-rich repeat 494..515 CDD:275380 3/20 (15%)
LRR 19 501..524 5/22 (23%)
LRRCT 524..577 CDD:214507 11/56 (20%)
TIR 636..779 CDD:214587 51/143 (36%)
Blue background indicates that the domain is not in the aligned region.

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