Protein Alignment Tl and LOC572462

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: XP_073768828.1
• Gene: LOC572462 / 572462
• -ID: -
• Length: 896
• Species: Danio rerio
• Alignment Length: 962
• Identity: 211/962 - (21%)
• Similarity: 353/962 - (36%)
• Gaps: 325/962 - (33%)

  Fly   191 HLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEG-ATSVLGI---- 250
            |.|.|:|.|....|           ..||....:.|::..      .|.|..| .|::|.:
Zfish    34 HFFSDVEGLNIASF-----------YHGKTSIAECLSVTD------IKEDLRGLPTNLLNLLVQM 81

  Fly   251 DIHDNGI---------------------EQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKH 294
            |:|.:|:                     .::|.:.|..|||||.:.::|          .| :|:
Zfish    82 DLHFHGVLAPNSFSRFGSLENLKIAGCFSEIPPEAFNGLTNVTSLTITA----------LD-SKN 135

  Fly   295 LNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPA 359
            ..||.|..:.:|..|   .||.:..:|.:|.|.. .:.:|...:.:...:....|.|.|.:....
Zfish   136 CCEVALDFSHLPSLT---SLFISHHDLSLLALNV-FEKIPHLQWLYLDSVCLKDLSDVLCRLANV 196

  Fly   360 TLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRN 424
            .||:    |.|||..|.||.:...|:|    |.||:..|.::.|             |.|::  .
Zfish   197 KLLK----LFSLDDWNIRLQYQNCSVF----NTTDISTEFSIET-------------VDLLL--G 238

  Fly   425 RLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPL--------------------------------- 456
            :|..||..||.....|..||...::.|..:.|
Zfish   239 KLEHIDEGAFKPFGKLSLLHFSVSNTDFLEDLSLIGVHQISKISAIVDVLNVDDLCVAAKLYSVK 303

  Fly   457 -LDIMLQTQIN-----------SPFGYMHGLLTL---------NLRN-NSIIFVY---------- 489
             :|:..:| ||           ...||    :||         ||.: ||:..::
Zfish   304 SVDVYYKT-INLSLTSKGSVGCKEIGY----ITLENDISREIVNLLDVNSVFQIFSNLTSAAIYR 363

  Fly   490 -----NDWK--------------NTMLQLRELD-------LSYNNISSLG--------YEDLAFL 520
                 ||::              |.:||...:|       :.:.|:.:|.        :||.||:
Zfish   364 HVLRSNDFQSLCASYPQNVKQLINMVLQTIRIDKIVSHQFMCFVNLKTLKLVMSKISVFEDFAFI 428

  Fly   521 SQNRL-HVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQ---------- 574
            ..|:| .:|:..|||..|    ..|...|.:...| :||.:||::       :|:
Zfish   429 GLNKLKELNLHRNKISSI----HRHTFSGLHELRV-LDLQENPII-------YIEPKSFGHFTNL 481

  Fly   575 ---LVRGVHKPQYSRQFKLRTDRLVCSQP----NVLEGTPVRQIEPQTLICPLDFSDDPRERKCP 632
               |:..::.|......||....:....|    ||...:.:|   |..|:...:.:       ..
Zfish   482 SSFLLGDLNFPPNMSLIKLHLSDIFGVIPYNLSNVFISSGLR---PMHLVIGSNTT-------LN 536

  Fly   633 RGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLR-LPSANTPGYESVTS 696
            .|.|.|::. ...:|.:|:|..||.|..|     .:|...:..||..:.: :||..:..::|:.|
Zfish   537 NGLNLHIKG-QYVIVEDCNSLLLTSVFTL-----QIQAAYMICENEFIGKYVPSVVSLEFQSMFS 595

  Fly   697 ------------LHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLG-------------- 735
                        :||....|..:|:    |||.::||.:::|..|...:|.
Zfish   596 DNIGDLSVINQLVHLKTLKLEKLDL----TNLPNMDIMFHNLTKLETLILANCKLFFLDGSLTKD 656

  Fly   736 --------------------FLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMM 780
                                |::...:.|.|.|......|.|....|:.:.:||     .:.|::
Zfish   657 LKALTKLGLIPKDTVNILQTFVDHLTQLRFVYLEDLDLYCSCDNAWLVSWIRDN-----RKVEVV 716

  Fly   781 CVNAEMPTRMVELSTNDI------------CP--------AEKGVFIALAVVIALTGLLAGFTAA 825
            ..|..|.. :..|:.|::            |.        |...||:.:.:|:.|.....|
Zfish   717 MSNPSMQD-LKCLTDNEVDHISFVSYVTENCSFDLDFVFFACSSVFLCIFIVVVLMYKFVG---- 776

  Fly   826 LYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDK---KFDAFISYSHKDQSFIEDYLVPQLE-HGPQ 886
            .|:|        .:.|....|| .|....|:|   ::|||:|||.||:.::.:.|:|.|| .||.
Zfish   777 QYFK--------PFYHIASGWF-REAFRMKEKQQYRYDAFVSYSSKDEHWVIEELLPNLEQRGPP 832

  Fly   887 KFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAA 938
            ..:||:|.||:.:|..|.|||..|:..||||:.::|:|::.|.|..:|.:.|
Zfish   833 FLRLCLHSRDFQLGHDIVENITDSIYASRRTLCLVSRNYLNSNWCSVEMQLA 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	9/41 (22%)
		leucine-rich repeat	176..198	CDD:275380	3/6 (50%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		LRR	222..576	CDD:443914	100/492 (20%)
		leucine-rich repeat	223..270	CDD:275380	12/72 (17%)
		leucine-rich repeat	271..294	CDD:275380	4/22 (18%)
		leucine-rich repeat	295..320	CDD:275380	7/24 (29%)
		leucine-rich repeat	321..343	CDD:275380	4/21 (19%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	9/22 (41%)
		leucine-rich repeat	392..415	CDD:275380	4/22 (18%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..474	CDD:275380	11/78 (14%)
		leucine-rich repeat	475..498	CDD:275380	9/61 (15%)
		leucine-rich repeat	499..520	CDD:275380	6/35 (17%)
		leucine-rich repeat	523..552	CDD:275380	9/29 (31%)
		LRRCT	561..619	CDD:214507	13/74 (18%)
		LRRNT	631..667	CDD:214470	10/35 (29%)
		PPP1R42	<660..752	CDD:455733	24/138 (17%)
		leucine-rich repeat	664..693	CDD:275380	5/29 (17%)
		leucine-rich repeat	694..715	CDD:275380	5/32 (16%)
		leucine-rich repeat	716..737	CDD:275380	6/54 (11%)
		LRRCT	751..800	CDD:214507	10/60 (17%)
		TIR	858..996	CDD:214587	35/82 (43%)
LOC572462	XP_073768828.1	None