DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tl and TLR8

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_057694.2 Gene:TLR8 / 51311 HGNCID:15632 Length:1059 Species:Homo sapiens


Alignment Length:1204 Identity:266/1204 - (22%)
Similarity:429/1204 - (35%) Gaps:413/1204 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 SEASFGRD-------------ACSEMSIDGLCQ-CAPIMSEYEIICPANAENPTF-------RLT 68
            |..|.|::             .|..:.|.|.|: ||.........|....:|.:.       ||.
Human     9 SSCSLGKETKKENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQ 73

  Fly    69 IQPKDYVQIMCNLTDTTD----------YQQLPK--KLRIGEVDRVQMRRCMLPGHTPIASILDY 121
            ..|:...:.:..| |.:|          :|.|..  |:.:.....||.:.    |:..|.|    
Human    74 EVPQTVGKYVTEL-DLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQN----GNPGIQS---- 129

  Fly   122 LGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANL---LTDMR--------- 174
                           .|:|||......|..|:.......:|..||:.|   ||::.         
Human   130 ---------------NGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNI 179

  Fly   175 ---------NLSHLEL-----------RANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGK 219
                     ||.:|.|           :.|||:   .:|:.|.|||.:....|.|..:|    .|
Human   180 TKEGISRLINLKNLYLAWNCYFNKVCEKTNIED---GVFETLTNLELLSLSFNSLSHVP----PK 237

  Fly   220 MP-KLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDN---------------GIEQLPHDVFA-- 266
            :| .|::|.|.:.|:..:::.||:|..::..:|:..|               |...:..|.||  
Human   238 LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQ 302

  Fly   267 HLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVP--------LATLP------------ 311
            :||.:..:|||:...|.:....|.:..||..:.|..|.:.        |..||            
Human   303 NLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYI 367

  Fly   312 ----------SRLFANQPELQILRLRAEL-QSLPGDLFEHSTQITNIS---LGDNLLKTLPATLL 362
                      ||.|:....|:.|.||..: |.|..|.|:...|:.|:|   ||.|.:|.:...|.
Human   368 KGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLF 432

  Fly   363 EHQVNLLSLDLSNNRLTHL-----------------------------PDSLFAHTT-------- 390
            ::..||..:.||.||::.|                             |.|.|.|.|        
Human   433 QNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQC 497

  Fly   391 ----NLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRN-RLRTIDSRAFVSTNGLRHLHLDHNDI 450
                ...||.|  |.:..|..:.|.||.::..|.:|.| ..:.:....|.:...:::|.|.:|.:
Human   498 AAYGKALDLSL--NSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRL 560

  Fly   451 DLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNN----ISS 511
            |..                            |.|.:...:|       |..||||||:    |:.
Human   561 DFD----------------------------NASALTELSD-------LEVLDLSYNSHYFRIAG 590

  Fly   512 LGYEDLAFLSQ--NRLHVNMTHNKIRRIALPEDVHLGEGYN---NNLVHVDLNDNPLVCDCTILW 571
            :.:. |.|:..  |...:|::||.|        ..|.:.||   .:||.:..:.|.|    .|||
Human   591 VTHH-LEFIQNFTNLKVLNLSHNNI--------YTLTDKYNLESKSLVELVFSGNRL----DILW 642

  Fly   572 ------FIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERK 630
                  :|.:.:|:..                                   :..||.|       
Human   643 NDDDNRYISIFKGLKN-----------------------------------LTRLDLS------- 665

  Fly   631 CPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVT 695
                             :|    .|.|:|....|:....|.|||:.:|.|..........:..:.
Human   666 -----------------LN----RLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLE 709

  Fly   696 SLHLAGNNLTSID-------------------VDQLP-------TNLTHLDISWNHLQMLNATVL 734
            .|.|.||.|..:.                   :..||       ::|.|||:|.|.|:.:|.:.|
Human   710 LLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSAL 774

  Fly   735 GFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMM--CVNAEMPTRMVELSTND 797
            . ...|.|...::|.|||:.|.|.              |||....|  .:|.::| |:|::    
Human   775 E-TKTTTKLSMLELHGNPFECTCD--------------IGDFRRWMDEHLNVKIP-RLVDV---- 819

  Fly   798 ICPA---EKGVFIALAVVIALTGLLAGFTAALYYKF----QTEIKIWLYAHNLL---LWFVTEED 852
            ||.:   ::|..|   |.:.||..::..||.:.:.|    .|.:.:...||:|.   :||:....
Human   820 ICASPGDQRGKSI---VSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVC 881

  Fly   853 LDKDKK----------FDAFISYSHKDQSFIEDYLVPQL-----EHGPQKFQLCVHERDWLVGGH 902
            |.|.|.          :||:|||..||.| :.|:::.:|     |...:...||:.||||..|..
Human   882 LAKVKGYRSLSTSQTFYDAYISYDTKDAS-VTDWVINELRYHLEESRDKNVLLCLEERDWDPGLA 945

  Fly   903 IPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEE 967
            |.:|:|:|:..|::|:.||::.:.||...:..|..|.:..::|....||.|:...:       .:
Human   946 IIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPV-------LQ 1003

  Fly   968 LKAYLKM------NTYLKWGD-----PWFWDKLR 990
            ...||::      ::.|:|.|     ..||..||
Human  1004 HSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLR 1037

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697 20/88 (23%)
leucine-rich repeat 176..198 CDD:275380 8/32 (25%)
leucine-rich repeat 199..222 CDD:275380 7/23 (30%)
LRR 222..576 CDD:443914 103/461 (22%)
leucine-rich repeat 223..270 CDD:275380 14/63 (22%)
leucine-rich repeat 271..294 CDD:275380 5/22 (23%)
leucine-rich repeat 295..320 CDD:275380 9/54 (17%)
leucine-rich repeat 321..343 CDD:275380 8/22 (36%)
leucine-rich repeat 344..367 CDD:275380 7/25 (28%)
leucine-rich repeat 368..391 CDD:275380 11/63 (17%)
leucine-rich repeat 392..415 CDD:275380 8/22 (36%)
leucine-rich repeat 416..439 CDD:275380 4/23 (17%)
leucine-rich repeat 440..474 CDD:275380 4/33 (12%)
leucine-rich repeat 475..498 CDD:275380 3/22 (14%)
leucine-rich repeat 499..520 CDD:275380 9/24 (38%)
leucine-rich repeat 523..552 CDD:275380 8/31 (26%)
LRRCT 561..619 CDD:214507 7/63 (11%)
LRRNT 631..667 CDD:214470 5/35 (14%)
PPP1R42 <660..752 CDD:455733 27/117 (23%)
leucine-rich repeat 664..693 CDD:275380 7/28 (25%)
leucine-rich repeat 694..715 CDD:275380 7/46 (15%)
leucine-rich repeat 716..737 CDD:275380 9/20 (45%)
LRRCT 751..800 CDD:214507 13/50 (26%)
TIR 858..996 CDD:214587 43/159 (27%)
TLR8NP_057694.2 LRR 81..460 CDD:443914 93/409 (23%)
leucine-rich repeat 83..106 CDD:275380 5/23 (22%)
leucine-rich repeat 107..144 CDD:275380 11/59 (19%)
leucine-rich repeat 145..165 CDD:275380 5/19 (26%)
leucine-rich repeat 166..189 CDD:275380 2/22 (9%)
leucine-rich repeat 190..220 CDD:275380 8/32 (25%)
leucine-rich repeat 221..241 CDD:275380 7/23 (30%)
leucine-rich repeat 242..265 CDD:275380 7/22 (32%)
leucine-rich repeat 266..306 CDD:275380 7/39 (18%)
leucine-rich repeat 307..330 CDD:275380 5/22 (23%)
leucine-rich repeat 331..356 CDD:275380 5/24 (21%)
leucine-rich repeat 387..413 CDD:275380 9/25 (36%)
leucine-rich repeat 414..437 CDD:275380 6/22 (27%)
LRR 483..>793 CDD:443914 86/423 (20%)
leucine-rich repeat 504..524 CDD:275380 8/21 (38%)
leucine-rich repeat 525..549 CDD:275380 4/23 (17%)
leucine-rich repeat 550..573 CDD:275380 6/50 (12%)
leucine-rich repeat 574..603 CDD:275380 10/29 (34%)
leucine-rich repeat 604..658 CDD:275380 16/65 (25%)
leucine-rich repeat 659..683 CDD:275380 8/51 (16%)
leucine-rich repeat 684..707 CDD:275380 6/22 (27%)
leucine-rich repeat 708..730 CDD:275380 5/21 (24%)
leucine-rich repeat 732..755 CDD:275380 2/22 (9%)
leucine-rich repeat 756..775 CDD:275380 8/18 (44%)
PCC 760..>847 CDD:188093 30/109 (28%)
TIR 898..1040 CDD:214587 43/148 (29%)

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