DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tl and chp

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_001263137.1 Gene:chp / 43690 FlyBaseID:FBgn0267435 Length:1338 Species:Drosophila melanogaster


Alignment Length:1044 Identity:223/1044 - (21%)
Similarity:374/1044 - (35%) Gaps:330/1044 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ALLVIILQLLQWPG-SEAS-FGRD-------ACSEMSIDGLCQCAPIMSEYEIICPANAENPTF- 65
            |.|.|.|.::.|.. :.|| |.|:       .|   :.:.:|.|:...::..|:...|...|.. 
  Fly    12 AFLTITLMIMIWMSLARASMFDREMEETHYPPC---TYNVMCTCSKSSTDLGIVHCKNVPFPALP 73

  Fly    66 RLTIQPKDYVQIMCN--LTDTTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILD--YLGIV- 125
            |:..|.|.::..|.|  |.:...|          .:....|.|..:.|: .:..|.|  :.|:. 
  Fly    74 RMVNQSKVFMLHMENTGLREIEPY----------FLQSTGMYRLKISGN-HLTEIPDDAFTGLER 127

  Fly   126 SPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMR-NLSHLELRAN-IEEM 188
            |...||...::| :.|..:.|..|..|:........:|||..:....:. :|..|.||.| |.::
  Fly   128 SLWELILPQNDL-VEIPSKSLRHLQKLRHLDLGYNHITHIQHDSFRGLEDSLQTLILRENCISQL 191

  Fly   189 PSHLFDDLENLESIEFGSNKLRQMPRGIF-GKMPKLKQLNLWSNQL------------------- 233
            .||.|..|..||:::...|.|.::...:| ..||:|.:|.|..|.|                   
  Fly   192 MSHSFSGLLILETLDLSGNNLFEIDPNVFVDGMPRLTRLLLTDNILSEIPYDALGPLKSLRTLDI 256

  Fly   234 -HNLT-----KHDFE-GATSVLGID---IHDNGIEQLPHDVFAH--------------------- 267
             ||:.     ...:| .|::.|.:|   :..|.||.||.:.|.:                     
  Fly   257 SHNVIWSLSGNETYEIKASTKLNLDNLHLEYNHIEVLPPNSFKYFDTVNRTFFDGNPIHTLREDA 321

  Fly   268 ---------------LTNVTDI------------NLSANLFRSLPQGLFDHNKHLNEVRLMNNRV 305
                           |||::.:            :||.|....|...||::...|..:.:.:|::
  Fly   322 FKPARIREIYMRYCGLTNISPVAFDSLVNSLQILDLSGNNLTKLHHKLFNNFDVLRVISMRDNKI 386

  Fly   306 ----PLATL------------------PSRL-----FANQPELQILRL----------------- 326
                |..|.                  |:.|     ..|...|.|.||                 
  Fly   387 KIQKPTETFNAVHYTLLKLDLSGDRNDPTNLQTLRKMRNMRSLSISRLGSSSVGPEDFKDFGVEL 451

  Fly   327 ------RAELQSLPGDLFEHSTQITNISLGDNLLKT--------------------------LPA 359
                  ||.|..:....|:|...:..:...:|.:.:                          |||
  Fly   452 EDLQITRASLSGIQSHAFKHVRGLKRLDFSENGISSIENDAFHEIGHSLISLKMSHGYSGSALPA 516

  Fly   360 TLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDN----LLTG-ISGDIFSNLGNLVTL 419
            ..|.|..:|..||.|||.::.:.|:.|....||..|.|.||    :|.| ..|||.|.|..   :
  Fly   517 EPLRHLTSLQELDFSNNHISSMSDTSFHFLKNLRLLELHDNRIEQVLKGTFQGDIHSKLEE---I 578

  Fly   420 VMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNS 484
            .:..|.|.:|....|.....||.||||.|.||..:           ...|..:..|..|:||.|.
  Fly   579 SLRFNHLTSISQHTFFDLEALRKLHLDDNKIDKIE-----------RRAFMNLDELEYLSLRGNK 632

  Fly   485 IIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQ----NRLHVNMTHNKIRRIAL-----P 540
            |..:.::....:.:|..||:::|.:.:..::   :..|    :.|:||::||:||::..     .
  Fly   633 INNLADESFQNLPKLEILDMAFNQLPNFNFD---YFDQVGTLSNLNVNVSHNQIRQLMYNSSWSG 694

  Fly   541 EDVHLGEGYNNNLVHVDLNDN-----------PLVCDCTIL----------------------WF 572
            .:.| |..|::|:..:||:.|           |.....|.|                      |.
  Fly   695 RNEH-GGMYHSNIKILDLSHNNISIIHPGYFRPAEISLTHLHLGYNSLMNTTRDVFGNMPHLQWL 758

  Fly   573 IQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNC 637
            ......:|:..:......:..:||....|.|...|....:|...:..:|||.:            
  Fly   759 DLSYNWIHELDFDAFKNTKQLQLVFFGHNYLSDIPQDIFKPVQGLRIVDFSHN------------ 811

  Fly   638 HVRTYDKALVINCHSGNLTHVPRLP-NLHKNMQLMELHLENNTLLRLPSANTPGYESVT--SLHL 699
                               |:..|| ||..|..:.:|.:.:|.:|::||::.....::|  .|||
  Fly   812 -------------------HLRGLPDNLFYNGGMEKLDVSHNMMLKIPSSSLSSLAALTLCELHL 857

  Fly   700 AGN---NLTSIDVDQLPTNLTHLDISWNH-------------------------LQMLNATVLGF 736
            :.|   .:.|:|:.....:|.:||||:|:                         |::::.:.:|.
  Fly   858 SNNFISTIHSMDLSNKFRSLRYLDISYNYLLRIDDAVFATMPKLAVLDLSHNRDLKVMDKSFMGL 922

  Fly   737 LNRTMK--WRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMP-----TRMVELS 794
            .|..:|  ..::.||..|   :...|.|..|      |:| .||:..:..|:.     .||::||
  Fly   923 ENSLIKLGLENISLSTVP---EIRLKYLREF------RLG-YNELPSIPQELAHNMSNLRMLDLS 977

  Fly   795 TNDI 798
            .||:
  Fly   978 NNDL 981

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697 21/61 (34%)
leucine-rich repeat 176..198 CDD:275380 10/22 (45%)
leucine-rich repeat 199..222 CDD:275380 6/23 (26%)
LRR 222..576 CDD:443914 112/553 (20%)
leucine-rich repeat 223..270 CDD:275380 18/111 (16%)
leucine-rich repeat 271..294 CDD:275380 6/34 (18%)
leucine-rich repeat 295..320 CDD:275380 7/51 (14%)
leucine-rich repeat 321..343 CDD:275380 9/44 (20%)
leucine-rich repeat 344..367 CDD:275380 6/48 (13%)
leucine-rich repeat 368..391 CDD:275380 8/22 (36%)
leucine-rich repeat 392..415 CDD:275380 12/27 (44%)
leucine-rich repeat 416..439 CDD:275380 4/22 (18%)
leucine-rich repeat 440..474 CDD:275380 10/33 (30%)
leucine-rich repeat 475..498 CDD:275380 6/22 (27%)
leucine-rich repeat 499..520 CDD:275380 4/20 (20%)
leucine-rich repeat 523..552 CDD:275380 10/33 (30%)
LRRCT 561..619 CDD:214507 12/90 (13%)
LRRNT 631..667 CDD:214470 5/36 (14%)
PPP1R42 <660..752 CDD:455733 29/124 (23%)
leucine-rich repeat 664..693 CDD:275380 7/28 (25%)
leucine-rich repeat 694..715 CDD:275380 7/25 (28%)
leucine-rich repeat 716..737 CDD:275380 8/45 (18%)
LRRCT 751..800 CDD:214507 15/53 (28%)
TIR 858..996 CDD:214587
chpNP_001263137.1 LRR <84..320 CDD:443914 55/247 (22%)
leucine-rich repeat 84..103 CDD:275380 4/28 (14%)
leucine-rich repeat 104..128 CDD:275380 6/24 (25%)
leucine-rich repeat 129..152 CDD:275380 6/23 (26%)
leucine-rich repeat 153..177 CDD:275380 4/23 (17%)
leucine-rich repeat 178..201 CDD:275380 10/22 (45%)
leucine-rich repeat 202..226 CDD:275380 6/23 (26%)
leucine-rich repeat 227..250 CDD:275380 5/22 (23%)
leucine-rich repeat 251..279 CDD:275380 4/27 (15%)
leucine-rich repeat 280..326 CDD:275380 7/45 (16%)
leucine-rich repeat 327..348 CDD:275380 3/20 (15%)
leucine-rich repeat 352..375 CDD:275380 6/22 (27%)
PPP1R42 355..564 CDD:455733 42/208 (20%)
leucine-rich repeat 376..401 CDD:275380 4/24 (17%)
leucine-rich repeat 426..450 CDD:275378 4/23 (17%)
leucine-rich repeat 451..474 CDD:275380 5/22 (23%)
LRR_8 473..559 CDD:404697 20/85 (24%)
leucine-rich repeat 475..524 CDD:275380 6/48 (13%)
leucine-rich repeat 500..519 CDD:275380 3/18 (17%)
leucine-rich repeat 525..548 CDD:275380 8/22 (36%)
LRR <540..>834 CDD:443914 75/342 (22%)
leucine-rich repeat 549..574 CDD:275380 10/24 (42%)
leucine-rich repeat 575..598 CDD:275380 5/25 (20%)
leucine-rich repeat 599..622 CDD:275380 10/33 (30%)
leucine-rich repeat 623..646 CDD:275380 6/22 (27%)
leucine-rich repeat 647..730 CDD:275380 20/86 (23%)
leucine-rich repeat 648..673 CDD:275380 4/27 (15%)
leucine-rich repeat 674..705 CDD:275380 10/31 (32%)
LRR <730..1081 CDD:443914 58/293 (20%)
leucine-rich repeat 731..754 CDD:275380 2/22 (9%)
leucine-rich repeat 755..778 CDD:275380 2/22 (9%)
leucine-rich repeat 779..802 CDD:275380 6/22 (27%)
leucine-rich repeat 803..823 CDD:275380 8/50 (16%)
leucine-rich repeat 852..876 CDD:275380 6/23 (26%)
leucine-rich repeat 877..900 CDD:275380 6/22 (27%)
leucine-rich repeat 901..925 CDD:275380 2/23 (9%)
leucine-rich repeat 926..946 CDD:275380 4/22 (18%)
leucine-rich repeat 947..970 CDD:275380 7/29 (24%)
leucine-rich repeat 971..993 CDD:275380 6/11 (55%)
leucine-rich repeat 994..1014 CDD:275380
leucine-rich repeat 1019..1042 CDD:275380
Blue background indicates that the domain is not in the aligned region.

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