Protein Alignment Tl and CG5810

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_650952.2
• Gene: CG5810 / 42513
• FlyBaseID: FBgn0038866
• Length: 428
• Species: Drosophila melanogaster
• Alignment Length: 438
• Identity: 97/438 - (22%)
• Similarity: 174/438 - (39%)
• Gaps: 88/438 - (20%)

  Fly   126 SPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLE-LRANIEEMP 189
            |.:.:.:.|:|:..::.:.....||        :..|.::|..:..::..|.... |...::::.
  Fly    47 SASAVAYFSENVTKHLRKYETLVLH--------SSDLANLPRKIFLNLPQLVEFHVLECELQQIE 103

  Fly   190 SHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHD 254
            |..||..:||:.:.||.|.||.:....|....:|::|||..|||.:|....|....::..|::.:
  Fly   104 SVCFDGAKNLKRLNFGGNALRVLDSNTFELATQLEELNLSDNQLEDLPTTIFRPLKNLQKINLSN 168

  Fly   255 NGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLF-DHNKHLNEVRLMNNRVPLATLPSRLFAN- 317
            |.:..|...:|:.|.::..||:.:|....||..|| |..|||:|....:|:  |..:|..:|..
  Fly   169 NRLITLSQHIFSQLGSLKSINVDSNQLVELPGELFRDQRKHLSEFSAQSNQ--LVRIPFNIFREI 231

  Fly   318 -------QPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSN 375
                   .|:|:.|.|.|::..|...    :..:.::.|...::    ...||....|..|.:|.
  Fly   232 DHLSLSFNPQLRRLHLSAKINELEAT----NCDLESVELDGRVI----GVQLEANPKLHELKISQ 288

  Fly   376 NR-LTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNG 439
            .: |.|    |:...|||..|            |..|....||.|.:: :.:...|.....|..|
  Fly   289 PQDLEH----LYLANTNLYRL------------DFLSKASKLVDLDVT-DIVNLADLPKITSAKG 336

  Fly   440 LRHL-----HLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQL 499
            |..|     :|..|.:|:...|.|:              ..|.::......||:
  Fly   337 LERLSFTYDNLTSNHMDMLPHLKDL--------------NYLEISHEKGKEIFI----------- 376

  Fly   500 RELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGE 547
            ::||           ||. |:.:..|:.....:.:..:.||:|..:.|
  Fly   377 KDLD-----------EDF-FVEEAELNCGQLADLLEFVELPKDTTILE 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	18/59 (31%)
		leucine-rich repeat	176..198	CDD:275380	5/22 (23%)
		leucine-rich repeat	199..222	CDD:275380	7/22 (32%)
		LRR	222..576	CDD:443914	77/341 (23%)
		leucine-rich repeat	223..270	CDD:275380	14/46 (30%)
		leucine-rich repeat	271..294	CDD:275380	8/23 (35%)
		leucine-rich repeat	295..320	CDD:275380	6/32 (19%)
		leucine-rich repeat	321..343	CDD:275380	5/21 (24%)
		leucine-rich repeat	344..367	CDD:275380	3/22 (14%)
		leucine-rich repeat	368..391	CDD:275380	6/23 (26%)
		leucine-rich repeat	392..415	CDD:275380	4/22 (18%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..474	CDD:275380	7/38 (18%)
		leucine-rich repeat	475..498	CDD:275380	3/22 (14%)
		leucine-rich repeat	499..520	CDD:275380	4/20 (20%)
		leucine-rich repeat	523..552	CDD:275380	5/25 (20%)
		LRRCT	561..619	CDD:214507
		LRRNT	631..667	CDD:214470
		PPP1R42	<660..752	CDD:455733
		leucine-rich repeat	664..693	CDD:275380
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
CG5810	NP_650952.2	LRR	<61..353	CDD:443914	78/326 (24%)
		leucine-rich repeat	65..88	CDD:275380	4/30 (13%)
		leucine-rich repeat	89..112	CDD:275380	5/22 (23%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	5/22 (23%)
		leucine-rich repeat	185..209	CDD:275380	8/23 (35%)
		leucine-rich repeat	210..231	CDD:275380	6/22 (27%)