Protein Alignment Tl and Toll-7

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_523797.1
• Gene: Toll-7 / 37272
• FlyBaseID: FBgn0034476
• Length: 1446
• Species: Drosophila melanogaster
• Alignment Length: 1418
• Identity: 330/1418 - (23%)
• Similarity: 515/1418 - (36%)
• Gaps: 423/1418 - (29%)

  Fly    10 LALLVIILQLLQW----------PGSEAS------FGRDACSEMSIDG----LCQCAPIMSEYEI 54
            :|.::::|....|          ..||:|      .|..|.:.:|:.|    |....|..|.
  Fly     1 MAAILLLLLGFSWSLAVESALAPKESESSASAMLGAGTGAAATVSLSGDYSSLLSNVPAASP--- 62

  Fly    55 ICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQMRRCML------PGHT 113
             .|||...|:     .|.:......|.|.:.                    .|.|      ||
  Fly    63 -VPANPSQPS-----GPANQCSWSYNGTSSV--------------------HCALRLIERQPG-- 99

  Fly   114 PIASILDYLGIVSPTTLIFESDNLGM---NITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRN 175
                 ||..|....:.|..:...|.:   .:......||..|:..|..:.:|..:|.|....:..
  Fly   100 -----LDLQGADGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLAT 159

  Fly   176 LSHLELRA-NIEEMPS---HLFDD----LENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQ 232
            |..|.|.. |.|..|:   .||.|    |:.|..::.|.|.|||:|.|....:..|:.|||..|:
  Fly   160 LKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNR 224

  Fly   233 LHNLTKHDFE----GATS--------VLG-----------------------IDIHDNGIEQLPH 262
            :....:..|.    ||.|        ||.                       :::..|.:.:|..
  Fly   225 IRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSG 289

  Fly   263 DVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLF------------ 315
            :..|.|.::..:|||.|...:||:|||..:|.|.|:.|..|.  |..||..||
  Fly   290 EALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNE--LYELPKGLFHRLEQLLVVDLS 352

  Fly   316 -----ANQPE---------------------------------LQILRLR--------------- 327
                 :|..:                                 ||||.||
  Fly   353 GNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPL 417

  Fly   328 --------AE--LQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLP 382
                    ||  |.:|...||.....::.::|.:||:..:...:.::..:|..||||:|:|..:|
  Fly   418 YNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVP 482

  Fly   383 DSL-----------------------FAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRN 424
            .:|                       |.:...||.|||.||.:..|:..:|.:|..|..|.:::|
  Fly   483 RALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKN 547

  Fly   425 RLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVY 489
            |:::|:..:|.....|..:.||.|.:            ..||..|..:..||.|||..|.:  |:
  Fly   548 RIQSIERGSFDKNFELEAIRLDRNFL------------ADINGVFATLVSLLWLNLSENHL--VW 598

  Fly   490 NDWKNTMLQLRELDLSYNNISSLG-YEDLAFLSQNRLHV---NMTHNKIRRI---ALPEDVHLGE 547
            .|:......|:.||:..|.|.:|| |..|    |..:.|   :.:||:|..|   ::|..:.|..
  Fly   599 FDYAFIPSNLKWLDIHGNYIEALGNYYKL----QEEIRVKTLDASHNRITEIGPMSIPNTIELLF 659

  Fly   548 GYNN--------------NLVHVD-----------------------------LNDNPLVCDCTI 569
            ..||              ||..||                             |..||..||||:
  Fly   660 INNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTM 724

  Fly   570 LWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQ---IEPQTLICP-----------L 620
            .| :|.:..:...|:.|...:.  .:.|..|:. .|..||.   :.||..:|.           .
  Fly   725 DW-LQRINNLTTRQHPRVMDMA--NIECVMPHA-RGAAVRPLSGLRPQDFLCRYESHCFALCHCC 785

  Fly   621 DFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPR---------------LPNL------ 664
            ||.....|..||..|.|:........|::|.....|.:||               .|.|
  Fly   786 DFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFI 850

  Fly   665 -HKNMQ----------------------LMELHLENNTLLRLPSANTPGYE-----SVTSLHLAG 701
             .||::                      |..|||.:|.|..|     .|||     ::..|:|..
  Fly   851 GRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTL-----HGYEFEQLSALRELYLQN 910

  Fly   702 NNLTSIDVDQLP--TNLTHLDISWNHLQML-----NATVLGFLNRTMKWRSVKLSGNPWMCDCT- 758
            |.||:|:...|.  ..|..:.|..|.|..|     :||..|     .:.:|:.|..|.|.|.|.
  Fly   911 NQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFG-----TRLKSISLGRNQWSCRCQF 970

  Fly   759 AKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVEL------------------STNDICP----- 800
            .:.|..:..||...:.|..::.|:.|...|....|                  :|...|.
  Fly   971 LQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSG 1035

  Fly   801 ---AEKGV---FI-ALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKK 858
               .:.|:   :| .||..:||..||.  ..|:.:.|:..::|||:||..:..|....: :.:|.
  Fly  1036 GSMLQHGIPESYIPLLAAALALLFLLV--VIAMVFAFRESLRIWLFAHYGVRVFGPRCE-ESEKL 1097

  Fly   859 FDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQ 923
            :||.:.:|.||..|:..:|..|||.|....::|:..|| |........::.:...|||.:|:|::
  Fly  1098 YDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRD-LAHDATHYQLLEATRVSRRVVILLTR 1161

  Fly   924 NFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNTY--LKWGDPWFW 986
            ||:::||||.|.|.:...||.....::::|...::....:.|.||..|||.:..  ::..|..||
  Fly  1162 NFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSDRHFW 1226

  Fly   987 DKLRFALPHRRPVGNIGNGALIKTALKGSTDDKLE-------LIKPSPVTPPLTTPPAEATKNPL 1044
            :|||:|||...|... ||...::  |.....::::       |.:.:|  ||....||:|.....
  Fly  1227 EKLRYALPVDYPTFR-GNNYTLE--LDHHNHERVKQPASPGLLYRQAP--PPAYCGPADAVGIGA 1286

  Fly  1045 VAQLNGVTPHQAIMIANGKNGLTNLYTPNGK-----------SHGNGHINGAF 1086
            |.|   |.|..|.:.|..........||:.:           |.||.|::..:
  Fly  1287 VPQ---VVPVNASVPAEQNYSTATTATPSPRPQRRGEQPGSGSGGNHHLHAQY 1336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	23/66 (35%)
		leucine-rich repeat	176..198	CDD:275380	10/29 (34%)
		leucine-rich repeat	199..222	CDD:275380	8/22 (36%)
		LRR	222..576	CDD:443914	123/536 (23%)
		leucine-rich repeat	223..270	CDD:275380	15/81 (19%)
		leucine-rich repeat	271..294	CDD:275380	9/22 (41%)
		leucine-rich repeat	295..320	CDD:275380	10/41 (24%)
		leucine-rich repeat	321..343	CDD:275380	12/46 (26%)
		leucine-rich repeat	344..367	CDD:275380	3/22 (14%)
		leucine-rich repeat	368..391	CDD:275380	10/45 (22%)
		leucine-rich repeat	392..415	CDD:275380	10/22 (45%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		leucine-rich repeat	440..474	CDD:275380	7/33 (21%)
		leucine-rich repeat	475..498	CDD:275380	8/22 (36%)
		leucine-rich repeat	499..520	CDD:275380	9/21 (43%)
		leucine-rich repeat	523..552	CDD:275380	9/48 (19%)
		LRRCT	561..619	CDD:214507	17/60 (28%)
		LRRNT	631..667	CDD:214470	11/57 (19%)
		PPP1R42	<660..752	CDD:455733	32/147 (22%)
		leucine-rich repeat	664..693	CDD:275380	13/62 (21%)
		leucine-rich repeat	694..715	CDD:275380	7/22 (32%)
		leucine-rich repeat	716..737	CDD:275380	8/25 (32%)
		LRRCT	751..800	CDD:214507	13/67 (19%)
		TIR	858..996	CDD:214587	46/139 (33%)
Toll-7	NP_523797.1	LRR	45..473	CDD:443914	98/465 (21%)
		leucine-rich repeat	136..159	CDD:275380	5/22 (23%)
		leucine-rich repeat	160..190	CDD:275380	10/29 (34%)
		leucine-rich repeat	191..214	CDD:275380	8/22 (36%)
		leucine-rich repeat	215..248	CDD:275380	9/32 (28%)
		leucine-rich repeat	249..273	CDD:275380	2/23 (9%)
		leucine-rich repeat	274..297	CDD:275380	4/22 (18%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	9/24 (38%)
		leucine-rich repeat	346..371	CDD:275380	1/24 (4%)
		LRR	369..>675	CDD:443914	75/323 (23%)
		leucine-rich repeat	372..395	CDD:275380	0/22 (0%)
		leucine-rich repeat	396..419	CDD:275380	6/22 (27%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	3/22 (14%)
		leucine-rich repeat	468..488	CDD:275380	9/19 (47%)
		leucine-rich repeat	491..514	CDD:275380	1/22 (5%)
		leucine-rich repeat	515..536	CDD:275380	9/20 (45%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	7/33 (21%)
		leucine-rich repeat	586..626	CDD:275380	16/41 (39%)
		leucine-rich repeat	627..653	CDD:275380	7/29 (24%)
		LRRCT	716..772	CDD:214507	17/59 (29%)
		LRR	<812..>963	CDD:443914	36/160 (23%)
		leucine-rich repeat	812..829	CDD:275380	5/16 (31%)
		leucine-rich repeat	833..854	CDD:275380	2/20 (10%)
		leucine-rich repeat	855..878	CDD:275380	0/22 (0%)
		leucine-rich repeat	879..902	CDD:275380	10/27 (37%)
		leucine-rich repeat	903..926	CDD:275380	7/22 (32%)
		leucine-rich repeat	927..953	CDD:275380	8/30 (27%)
		TIR	1098..1235	CDD:214587	45/137 (33%)