DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tl and Tlr8

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_573475.2 Gene:Tlr8 / 170744 MGIID:2176887 Length:1032 Species:Mus musculus


Alignment Length:1029 Identity:232/1029 - (22%)
Similarity:392/1029 - (38%) Gaps:294/1029 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 ESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLE 197
            |:.| |||||...|..|..|........:|..|||.|...::.||.::  .||.::..:....|.
Mouse   105 ENKN-GMNITEGALLSLRNLTVLLLEDNQLYTIPAGLPESLKELSLIQ--NNIFQVTKNNTFGLR 166

  Fly   198 NLESIEFG------SNKLRQMPRGIFGKMPKLKQLNLWSNQLH---------------------N 235
            |||.:..|      .|:..::..|.|..:..||.|:|..|.|.                     |
Mouse   167 NLERLYLGWNCYFKCNQTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPSSLRKLFLSNAKIMN 231

  Fly   236 LTKHDFEGATSVLGIDIHDN--------------------GIEQLPHDVFAHLTNVTDINLSANL 280
            :|:.||:|..::..:|:..|                    .|..|   .|..||.:..:|||:..
Mouse   232 ITQEDFKGLENLTLLDLSGNCPRCYNAPFPCTPCKENSSIHIHPL---AFQSLTQLLYLNLSSTS 293

  Fly   281 FRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQIT 345
            .|::|...|::..:|.|:.|..|.:.............|.||||.|....|      ::...|..
Mouse   294 LRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLTKLPSLQILDLSFNFQ------YKEYLQFI 352

  Fly   346 NISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIF 410
            |||...:.|::|...   |....:..:|......|| .||    .||..:.|..|.:..|....|
Mouse   353 NISSNFSKLRSLKKL---HLRGYVFRELKKKHFEHL-QSL----PNLATINLGINFIEKIDFKAF 409

  Fly   411 SNLGNLVTLVMSRNRLRTI-DSRAFVS-TNGLR------------HLHLDHNDIDLQQP------ 455
            .|...|..:.:|.||:.:: |...:.| .|.||            |::..|:...|.:|      
Mouse   410 QNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHSTKPLIKPQCTAYG 474

  Fly   456 -LLDIML--------------------------QTQI--NSPFGYMHGLLTLNLRNNSIIFVYND 491
             .||:.|                          .||:  .:.|..|..:..|:|.||.:.|..|:
Mouse   475 KALDLSLNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNN 539

  Fly   492 WKNTMLQLRELDLSYN----NISSLGYEDLAFLSQNRLH---VNMTHN---------KIRRIALP 540
            ..:.:..|..||||:|    :|:.:.:. |.|: ||.::   :|::||         :::.|:|.
Mouse   540 AFSDLHDLEVLDLSHNAHYFSIAGVTHR-LGFI-QNLINLRVLNLSHNGIYTLTEESELKSISLK 602

  Fly   541 EDVHLGEGYN-----------------NNLVHVDLNDNPLVCDCTILWFIQLVRG--VHKPQYSR 586
            |.|..|...:                 .||:.:||:.|.|.         |:..|  ::.||..:
Mouse   603 ELVFSGNRLDRLWNANDGKYWSIFKSLQNLIRLDLSYNNLQ---------QIPNGAFLNLPQSLQ 658

  Fly   587 QFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCH 651
            :.             ::.|..:|..                                        
Mouse   659 EL-------------LISGNKLRFF---------------------------------------- 670

  Fly   652 SGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPT-- 714
              |.|.:...|:||.      |.|..|.|..||:..:....|:.:|.|:.|:.:     .||:  
Mouse   671 --NWTLLQYFPHLHL------LDLSRNELYFLPNCLSKFAHSLETLLLSHNHFS-----HLPSGF 722

  Fly   715 -----NLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIG 774
                 ||.|||:|:|.::|:|.:.|....:| ....::|.||.:.|.|.......:..:|     
Mouse   723 LSEARNLVHLDLSFNTIKMINKSSLQTKMKT-NLSILELHGNYFDCTCDISDFRSWLDEN----- 781

  Fly   775 DRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAAL--YYKFQTEIKIW 837
                   :|..:|..:..:.:|......|.:     :.:.||..::..|||:  :..|.|...:.
Mouse   782 -------LNITIPKLVNVICSNPGDQKSKSI-----MSLDLTTCVSDTTAAVLFFLTFLTTSMVM 834

  Fly   838 LYA--HNLL---LWFVTEEDLDKDKK----------FDAFISYSHKDQSFIEDYLVPQLEHGPQK 887
            |.|  |:|.   :||:......|.|.          :||:|||..||.| :.|:::.:|.:..::
Mouse   835 LAALVHHLFYWDVWFIYHMCSAKLKGYRTSSTSQTFYDAYISYDTKDAS-VTDWVINELRYHLEE 898

  Fly   888 FQ-----LCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGR 947
            .:     ||:.||||..|..|.:|:|:|:..|::||.||::.:.||...:..|..|.:..::|..
Mouse   899 SEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENM 963

  Fly   948 SRIIVIIYSDIGDVEKLDEELKAYLKM------NTYLKW-----GDPWFWDKLR 990
            ..||.|:...:       .:...||::      ::.|:|     .:..||..|:
Mouse   964 DVIIFILLEPV-------LQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLK 1010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697 17/64 (27%)
leucine-rich repeat 176..198 CDD:275380 5/21 (24%)
leucine-rich repeat 199..222 CDD:275380 6/28 (21%)
LRR 222..576 CDD:443914 106/476 (22%)
leucine-rich repeat 223..270 CDD:275380 17/87 (20%)
leucine-rich repeat 271..294 CDD:275380 6/22 (27%)
leucine-rich repeat 295..320 CDD:275380 4/24 (17%)
leucine-rich repeat 321..343 CDD:275380 6/21 (29%)
leucine-rich repeat 344..367 CDD:275380 6/22 (27%)
leucine-rich repeat 368..391 CDD:275380 5/22 (23%)
leucine-rich repeat 392..415 CDD:275380 6/22 (27%)
leucine-rich repeat 416..439 CDD:275380 6/24 (25%)
leucine-rich repeat 440..474 CDD:275380 13/80 (16%)
leucine-rich repeat 475..498 CDD:275380 6/22 (27%)
leucine-rich repeat 499..520 CDD:275380 8/24 (33%)
leucine-rich repeat 523..552 CDD:275380 9/57 (16%)
LRRCT 561..619 CDD:214507 8/59 (14%)
LRRNT 631..667 CDD:214470 5/35 (14%)
PPP1R42 <660..752 CDD:455733 28/98 (29%)
leucine-rich repeat 664..693 CDD:275380 8/28 (29%)
leucine-rich repeat 694..715 CDD:275380 5/27 (19%)
leucine-rich repeat 716..737 CDD:275380 9/20 (45%)
LRRCT 751..800 CDD:214507 7/48 (15%)
TIR 858..996 CDD:214587 41/159 (26%)
Tlr8NP_573475.2 LRR 1 41..61
LRR 2 62..85
leucine-rich repeat 65..88 CDD:275380
LRR 66..484 CDD:443914 97/398 (24%)
LRR 3 87..109 2/4 (50%)
leucine-rich repeat 89..122 CDD:275380 9/17 (53%)
LRR 4 120..143 7/22 (32%)
leucine-rich repeat 123..143 CDD:275380 6/19 (32%)
leucine-rich repeat 144..167 CDD:275380 5/24 (21%)
LRR 5 145..165 4/21 (19%)
LRR 6 166..194 7/27 (26%)
leucine-rich repeat 168..197 CDD:275380 6/28 (21%)
LRR 7 195..218 6/22 (27%)
leucine-rich repeat 198..218 CDD:275380 6/19 (32%)
leucine-rich repeat 219..242 CDD:275380 5/22 (23%)
LRR 8 220..239 4/18 (22%)
LRR 9 240..267 2/26 (8%)
leucine-rich repeat 243..283 CDD:275380 6/42 (14%)
LRR 10 281..304 8/22 (36%)
leucine-rich repeat 284..307 CDD:275380 6/22 (27%)
LRR 11 306..329 4/22 (18%)
leucine-rich repeat 308..327 CDD:275380 4/18 (22%)
LRR 12 331..360 11/34 (32%)
leucine-rich repeat 334..363 CDD:275380 11/34 (32%)
LRR 13 361..384 4/25 (16%)
leucine-rich repeat 364..390 CDD:275380 7/33 (21%)
LRR 14 388..411 7/26 (27%)
leucine-rich repeat 391..414 CDD:275380 6/22 (27%)
LRR 15 413..436 5/22 (23%)
leucine-rich repeat 465..497 CDD:275380 5/31 (16%)
LRR 16 471..494 3/22 (14%)
LRR_8 501..555 CDD:404697 15/53 (28%)
leucine-rich repeat 501..522 CDD:275380 4/20 (20%)
LRR 17 520..543 7/22 (32%)
leucine-rich repeat 523..546 CDD:275380 6/22 (27%)
LRR <532..791 CDD:443914 69/348 (20%)
LRR 18 545..572 9/28 (32%)
leucine-rich repeat 547..576 CDD:275380 11/30 (37%)
LRR 19 574..598 3/23 (13%)
leucine-rich repeat 577..600 CDD:275380 3/22 (14%)
LRR 20 600..621 4/20 (20%)
leucine-rich repeat 601..631 CDD:275380 4/29 (14%)
LRR 21 629..652 8/31 (26%)
leucine-rich repeat 632..656 CDD:275380 8/32 (25%)
LRR 22 654..677 6/77 (8%)
leucine-rich repeat 657..680 CDD:275380 4/77 (5%)
LRR 23 678..701 9/28 (32%)
leucine-rich repeat 681..704 CDD:275380 8/28 (29%)
LRR 24 702..725 6/27 (22%)
leucine-rich repeat 705..728 CDD:275380 5/27 (19%)
LRR 25 727..749 10/21 (48%)
leucine-rich repeat 729..748 CDD:275380 8/18 (44%)
LRR 26 752..776 6/24 (25%)
TIR 871..1007 CDD:214587 39/143 (27%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.