Protein Alignment Tl and Toll-6

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: XP_320172.2
• Gene: Toll-6 / 1280328
• VectorBaseID: AGAMI1_008433
• Length: 1459
• Species: Anopheles gambiae
• Alignment Length: 1368
• Identity: 328/1368 - (23%)
• Similarity: 512/1368 - (37%)
• Gaps: 409/1368 - (29%)

  Fly     1 MSRLKAASELALLVIILQL---LQWPGSEAS-------FGRDACSEMSIDGLCQCAPIMSEYEII 55
            |||.:......||::.:|:   ||:..:|:|       .|.:..|.:..|     ||...:|.|:
Mosquito     1 MSRCELLLPALLLLVSVQVNYSLQYDSAESSRYYHPAGAGSEPGSNLRYD-----APDDCKYRIL 60

  Fly    56 CPANAENPTFRLTIQPKDYVQIMCNLT------DTTDYQQLPKKLRIGEVDRVQMRRCMLPGHTP 114
                           |.:.|.:.|||.      |.|::..:|.:                  ||.
Mosquito    61 ---------------PGNEVDLACNLRTVNSEFDNTNFSVIPAE------------------HTA 92

  Fly   115 IASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLK-------RF------------RFTTR 160
            ..|||....|::.:.|:..|        ..||.||..|.       :|            .||.|
Mosquito    93 ALSILCNEAIMARSKLLPNS--------FVHLARLKALSLEFCKIAKFSSTVLAGLGDLRNFTLR 149

  Fly   161 RLTH----------IPANLLTDMRNLSHLELRA-NIEEMPSHLFDDLENLESIEFGSNKLRQ--- 211
              ||          |.|:.....|||..|:|.. ||..:|.|||..|..|.|:...||:|:.
Mosquito   150 --THNIAWPELNLEIEADAFGQTRNLEVLDLSTNNIWSLPDHLFCSLSGLRSLNISSNRLQDVND 212

  Fly   212 -----------------------------------------------MPRGIFGKMPKLKQLNLW 229
                                                           :|...||.:.:||.|.:.
Mosquito   213 LGFREKGVKDEVESEGHKTNSSGSVAPPVSCALDLEDLDVSRNHFVLLPAAGFGMLKRLKMLKIH 277

  Fly   230 SNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAH-LTNVTDINLSANLFRSLPQGLFDHNK 293
            .|::..:......|...:..:|:..|.:..||.|:|.. ..::.:|.|..|....|..|||...:
Mosquito   278 DNEISMVGDKALSGLKELQILDLSSNKLVALPTDLFRDPAQSIQEIYLQNNSISVLSPGLFSKLE 342

  Fly   294 HLNEVRLMNNRV------------------------PLATLPSRLFANQPELQILRLR-AELQSL 333
            .|..:.|..|::                        .:..|.|.:|::...||||.|| .:|:.:
Mosquito   343 QLQALDLSQNQLTSAWVNRDTFAGLIRLVLLNLASNKITKLESEIFSDLYTLQILNLRHNQLEII 407

  Fly   334 PGDLFEHSTQITNISLGDNLLKTLPATLLE--HQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLR 396
            ..|.|.....:..:.|..|.||.|.|..|.  :.::|||||  ||.||.:....|.:.::|.||.
Mosquito   408 AADTFSPMNNLHTLLLSHNKLKYLDAYSLNGLYALSLLSLD--NNALTGVHPEAFRNCSSLQDLN 470

  Fly   397 LEDNLLTGI-----------SGDI------------FSNLGNLVTLVMSRNRLRTIDSRAFVSTN 438
            |..|.||.:           :.|:            |..:.||..|.:..|.:..|..:||....
Mosquito   471 LNGNELTQVPLALKDMRLLRTVDLGENSISVIEEPGFRGMNNLYGLRLISNNIENITRKAFKDLP 535

  Fly   439 GLRHLHLDHNDI------------DLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSI-IFVYN 490
            .|:.|::..|.|            .:|...||..|.:.|:..|..|..|:.||:.:|.: .|.|:
Mosquito   536 SLQILNVARNKISYIEKGAFEPAVSVQAIRLDGNLLSDIDGLFTSMPNLVWLNISDNKLEHFDYS 600

  Fly   491 ------DW----KNTM------------LQLRELDLSYNNISSL------GYEDLAFLSQNRL-H 526
                  .|    :|.:            |.|:.||.|:|.::.:      ...:..||:.|.: |
Mosquito   601 HIPPHLQWLDLHRNELTELTNRYGLDNQLHLQTLDASFNRLTRVTPATIPNSIEFLFLNDNLIVH 665

  Fly   527 VN---MTH-NKIRRIAL------------------PEDVHLGEGYNNNLVHVDLNDNPLVCDCTI 569
            |.   .|| ..:.|:.|                  |||..:.|.|        :..||.||||.|
Mosquito   666 VEPHCFTHKTNLTRVDLYANQLTSLDIKALRLQPVPEDKQIPEFY--------IGGNPFVCDCNI 722

  Fly   570 LWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGT--PVRQIEPQTLICP-----------LD 621
            .| :|.:..|...||.....:.|  :.|......|.:  |:.:.||:..:|.           .:
Mosquito   723 DW-LQKINHVTSRQYPTINDIET--VYCKLMYNRERSYIPLIEAEPKHFLCSYNTHCFALCHCCE 784

  Fly   622 FSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVP-RLP----------------------- 662
            |.....|..||..|.|:........::.|.:...|.:| .:|
Mosquito   785 FDACDCEMTCPNNCACYHDNSWSTNIVECSAAGYTDIPNNIPMDTTEVYIDGNNLVELSGHSFIG 849

  Fly   663 --NL------HKNMQ------------LMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSI 707
              ||      |.|::            |..||||||.:.:|........||:..|:|.||.:..|
Mosquito   850 RKNLRVLYANHSNIEAIYNTTFIGLRRLTILHLENNAIRKLYGHEFSALESLRELYLQGNRIAYI 914

  Fly   708 DVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNP-----------WMCDC-TAK 760
            :           |.::..|:.|....|.. ||...:...:||.||           |.||| ...
Mosquito   915 E-----------DHTFAELRKLEVLRLDG-NRITSFEVWQLSANPYLVEIALANNLWTCDCGFVN 967

  Fly   761 PLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEKG----------------VFIAL 809
            .|..:.|.|.::|.|.||:.|......:.:.:..|.  |...:|                :.:|.
Mosquito   968 KLRSYLQSNADKIVDANEISCSYNNATSILRDNGTK--CTFREGMSSIVHRQEIEDMLPLLLVAT 1030

  Fly   810 AVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLW----FVTEEDLDKDKKFDAFISYSHKDQ 870
            ...:...||:.|.     :.::.|:|:|:  |:.|.:    ||.|  .|||:.:||:|:||.:|:
Mosquito  1031 CAFVGFFGLIFGI-----FCYRKELKVWV--HSGLCYKSGTFVNE--YDKDRLYDAYITYSLQDE 1086

  Fly   871 SFIEDYLVPQLEH--GPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARL 933
            .|:...|...||:  |   |:||:|.||.....::.:.|:.:|..|:|.|:|||::|:.:||.|.
Mosquito  1087 HFVSQILTSTLENDIG---FRLCLHYRDLNANAYLADTIVEAVESSKRAILVLSKSFLYNEWTRF 1148

  Fly   934 EFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRP 998
            ||:.|....|.. |.::|:|:|.|:.. ..||.:::.||:.||.::|.|..||.|||.||||.:.
Mosquito  1149 EFKGAIHEVLKR-RRKLIIILYGDLPQ-RDLDADMRLYLRTNTCIEWDDKKFWQKLRIALPHVKK 1211

  Fly   999 VGNIGNGALIKTALKGSTDDKLELIKPSPVTPPLTTPPAEATKNPLVA--QLNGVTPHQAIMIAN 1061
            ...:...:.|........|              ..||...:|..|.||  :|:|...|....|
Mosquito  1212 SNCLNKRSAINIYATAGND--------------YNTPGRPSTLGPSVASTRLDGPQHHSYATI-- 1260

  Fly  1062 GKN 1064
            |.|
Mosquito  1261 GPN 1263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	24/109 (22%)
		leucine-rich repeat	176..198	CDD:275380	10/22 (45%)
		leucine-rich repeat	199..222	CDD:275380	8/72 (11%)
		LRR	222..576	CDD:443914	114/468 (24%)
		leucine-rich repeat	223..270	CDD:275380	11/47 (23%)
		leucine-rich repeat	271..294	CDD:275380	7/22 (32%)
		leucine-rich repeat	295..320	CDD:275380	6/48 (13%)
		leucine-rich repeat	321..343	CDD:275380	9/22 (41%)
		leucine-rich repeat	344..367	CDD:275380	7/24 (29%)
		leucine-rich repeat	368..391	CDD:275380	10/22 (45%)
		leucine-rich repeat	392..415	CDD:275380	9/45 (20%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		leucine-rich repeat	440..474	CDD:275380	11/45 (24%)
		leucine-rich repeat	475..498	CDD:275380	8/45 (18%)
		leucine-rich repeat	499..520	CDD:275380	5/26 (19%)
		leucine-rich repeat	523..552	CDD:275380	12/51 (24%)
		LRRCT	561..619	CDD:214507	18/59 (31%)
		LRRNT	631..667	CDD:214470	11/67 (16%)
		PPP1R42	<660..752	CDD:455733	28/134 (21%)
		leucine-rich repeat	664..693	CDD:275380	11/46 (24%)
		leucine-rich repeat	694..715	CDD:275380	5/20 (25%)
		leucine-rich repeat	716..737	CDD:275380	4/20 (20%)
		LRRCT	751..800	CDD:214507	15/60 (25%)
		TIR	858..996	CDD:214587	54/139 (39%)
Toll-6	XP_320172.2	PPP1R42	<115..>213	CDD:455733	30/99 (30%)
		leucine-rich repeat	119..142	CDD:275380	3/22 (14%)
		PLN00113	173..>617	CDD:215061	103/445 (23%)
		leucine-rich repeat	173..196	CDD:275380	10/22 (45%)
		leucine-rich repeat	247..270	CDD:275380	3/22 (14%)
		leucine-rich repeat	271..294	CDD:275380	5/22 (23%)
		leucine-rich repeat	295..319	CDD:275380	6/23 (26%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	3/24 (13%)
		leucine-rich repeat	370..393	CDD:275380	3/22 (14%)
		leucine-rich repeat	394..417	CDD:275380	9/22 (41%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
		leucine-rich repeat	442..465	CDD:275380	10/24 (42%)
		leucine-rich repeat	466..488	CDD:275380	7/21 (33%)
		leucine-rich repeat	489..512	CDD:275380	2/22 (9%)
		leucine-rich repeat	513..534	CDD:275380	6/20 (30%)
		leucine-rich repeat	537..560	CDD:275380	4/22 (18%)
		leucine-rich repeat	561..583	CDD:275380	7/21 (33%)
		PRK15370	<600..>690	CDD:185268	17/89 (19%)
		leucine-rich repeat	631..676	CDD:275380	12/44 (27%)
		LRR	<819..>957	CDD:443914	32/149 (21%)
		leucine-rich repeat	829..852	CDD:275380	0/22 (0%)
		leucine-rich repeat	853..876	CDD:275380	3/22 (14%)
		leucine-rich repeat	877..900	CDD:275380	8/22 (36%)
		leucine-rich repeat	901..924	CDD:275380	7/33 (21%)
		TIR	1075..1208	CDD:214587	53/137 (39%)