Protein Alignment Tl and tlr7

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_001427675.1
• Gene: tlr7 / 100534776
• ZFINID: ZDB-GENE-040219-11
• Length: 1048
• Species: Danio rerio
• Alignment Length: 1212
• Identity: 253/1212 - (20%)
• Similarity: 449/1212 - (37%)
• Gaps: 406/1212 - (33%)

  Fly     4 LKAASELALLVI-----ILQLLQW-PGS---EASFGRDACSEMSIDGLCQCAP-IMSEYEIICPA 58
            :|..:|..::::     :|...:| |.|   :.|...:. :|:|:|    |.. .::|..:..|.
Zfish     1 MKTMTEKTMIILAGFISLLVAAEWYPKSLKCDVSLASNG-TEVSVD----CTERSLTEVPLGIPT 60

  Fly    59 NAENPTFRLTIQPKDYVQIMCNLTDTTDYQQ----LPKKLRIGEVDRVQMRRCMLPGHTPIASIL 119
            |..|.|..:...|........||.:.|:...    :|  :::|..|||    |
Zfish    61 NTTNLTLTINHIPHVMNNSFDNLHNITEIDLRCNCVP--VKVGPKDRV----C------------ 107

  Fly   120 DYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANL--------------- 169
                            :..::|......:|..||.......:|:.||..|
Zfish   108 ----------------SQSVSIDNGTFWKLKNLKSLYLDGNQLSSIPKGLPANIVLLSLEINSIY 156

  Fly   170 ------LTDMRNLSHLELRAN------------IEEMPSHLFDDLENLESIEFGSNKLRQMPRGI 216
                  ||::.|:..|.|..|            ||:   ..|..|:.:..:...||.|..:|
Zfish   157 SILQENLTELTNIRTLYLGQNCYFRNPCNQSYYIEK---DAFMLLDKMTLLSLKSNNLSYIP--- 215

  Fly   217 FGKMP-KLKQLNLWSNQLHNLTKHDFEGATSVLGID----------------------------- 251
             .::| .||:|.|::|.:..:|:.||...|.:..:|
Zfish   216 -NQLPSSLKELYLYNNNIEKITEKDFCNLTELEVLDLSGNCPRCYNAPFPCIPCPNNAPLQIHPN 279

  Fly   252 ------------IHDNGIEQLPHDVFAHLTNVTDINLSANLF------RSLPQGLFDHNKHLNEV 298
                        :|.|.:..:|.:.|..|.::|.::||:|..      .|.|..|    ..|.|:
Zfish   280 SFKTLKNLKTLRLHSNSLTNIPPEWFQSLADLTLLDLSSNFLAKEITCTSFPSLL----PKLEEL 340

  Fly   299 RLMNNRVPLATLPSRL-----FANQPELQILRLRA----ELQSLPGDLFEHSTQITNISLGDNLL 354
            .|..| ..|...|:.|     |:....|::||:|.    ||:........:.|.:..:.||.|.:
Zfish   341 DLSFN-YELQVYPASLSLSESFSQLKSLRVLRIRGYVFQELKLQDIQPLTNLTYLEFLDLGTNFI 404

  Fly   355 KTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFA-------------------HTTNLTDL----- 395
            |....::|::..|...::||:|:::...:..|:                   |...:.|:
Zfish   405 KIAQLSILKNLKNFKIINLSDNKISVPSEGEFSFSNHREAYYGSPMSQGAQYHNGEVKDMHYFLY 469

  Fly   396 -------RLEDNLL------------TGISGDI-----------FSNLGNLVTLVMSRNRL-RTI 429
                   :.:|..|            .|.:.||           |.|||.|..|.:|.|.: :::
Zfish   470 DEFARSCKYKDKELWIPSPFNNDCSSFGKTLDISRNNIFFLHSKFLNLGELRCLNLSGNAMSQSL 534

  Fly   430 DSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYN---- 490
            :...||....|::|....|.:||..|           |.|..:..|:.|::..||..||..
Zfish   535 NGSEFVQLTNLQYLDFTDNRLDLMYP-----------SAFQELSNLVVLDISRNSHYFVAEGLTH 588

  Fly   491 --DWKNTMLQLRELDLSYNNIS--------SLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHL 545
              ::...:.:||:|.::.|.||        |...|.|.| ..|||.:.......|.:
Zfish   589 MLNFTENLSKLRKLIMNDNQISTSTNTEMKSYKLEHLEF-KGNRLDMLWRDGDTRYV-------- 644

  Fly   546 GEGYNNNLV---HVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTP 607
              .|..||:   .:|::.|.|.       ||.||                         |.:|.|
Zfish   645 --NYFKNLMALKTLDISRNNLN-------FIPLV-------------------------VFQGLP 675

  Fly   608 VRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGN-LTHVPR-LPNLHKNMQL 670
                   ..:..|..:|:..:.....|.     .|.|:|::...:|| ||.||. |.|..|::|
Zfish   676 -------NTLTKLYITDNKLKLFKWEGL-----VYLKSLLLLDLTGNLLTEVPSCLSNYTKSIQ- 727

  Fly   671 MELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLG 735
             .|.|..|.:::|.........|:..|.|:.|::..||....|.|:.      :|||.|
Zfish   728 -TLVLSKNKIVKLSPNFLKDAFSLKILDLSYNSIQFIDESSFPENVI------DHLQTL------ 779

  Fly   736 FLNRTMKWRSVKLSGNPWMCDCTAKPLLLF---TQDNFERIGDRNEMMCVNAEMPTRMVELSTND 797
            :||..|           ::|.|.|..|:.:   |..|..|:.  :::.|.:..
Zfish   780 YLNNNM-----------FVCSCNATWLVRWINRTSVNIPRLA--SDVTCASPS------------ 819

  Fly   798 ICPAEKG---VFI--------ALAVVIALTGLLAGFTAALYYKFQTE-----IKIWLYAHNLL-- 844
               |:||   :|:        :|::::.:              |||.     :.:.:.:|..|
Zfish   820 ---AQKGQSVIFLNLQACQHNSLSIILCI--------------FQTTLILTILTLTISSHLFLWD 867

  Fly   845 LWFVTEEDLDKDK----------KFDAFISYSHKDQSFIEDYLVPQL-----EHGPQKFQLCVHE 894
            :|::....|.|.|          .:|||:.|...|.: ::::::.:|     :.|..:..||:.|
Zfish   868 VWYIYHFCLAKLKGYRRLSSNSAVYDAFVIYDTTDPA-VQEWVMQELRVHLEDKGDPRMNLCLEE 931

  Fly   895 RDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIG 959
            |||:.|..:.||:.:|:..|:||:.:|::.:|:|...|..|..||:..::| |:.:||:|:
Zfish   932 RDWVPGCPLIENLSQSIQLSQRTVFILTERYIRSGSFRTAFYLAHQRLMDE-RNDVIVLIF---- 991

  Fly   960 DVEKLDEELKAYLKM------NTYLKW-----GDPWFWDKLR 990
             :|::....| ||::      .:.|:|     ...:||..||
Zfish   992 -LERMPCHSK-YLRLRKRLYKKSVLEWPRNPQAQRYFWFSLR 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	18/71 (25%)
		leucine-rich repeat	176..198	CDD:275380	7/33 (21%)
		leucine-rich repeat	199..222	CDD:275380	5/23 (22%)
		LRR	222..576	CDD:443914	100/481 (21%)
		leucine-rich repeat	223..270	CDD:275380	15/87 (17%)
		leucine-rich repeat	271..294	CDD:275380	7/28 (25%)
		leucine-rich repeat	295..320	CDD:275380	8/29 (28%)
		leucine-rich repeat	321..343	CDD:275380	6/25 (24%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	5/41 (12%)
		leucine-rich repeat	392..415	CDD:275380	9/57 (16%)
		leucine-rich repeat	416..439	CDD:275380	6/23 (26%)
		leucine-rich repeat	440..474	CDD:275380	8/33 (24%)
		leucine-rich repeat	475..498	CDD:275380	6/28 (21%)
		leucine-rich repeat	499..520	CDD:275380	9/28 (32%)
		leucine-rich repeat	523..552	CDD:275380	5/28 (18%)
		LRRCT	561..619	CDD:214507	9/57 (16%)
		LRRNT	631..667	CDD:214470	12/37 (32%)
		PPP1R42	<660..752	CDD:455733	23/92 (25%)
		leucine-rich repeat	664..693	CDD:275380	6/28 (21%)
		leucine-rich repeat	694..715	CDD:275380	6/20 (30%)
		leucine-rich repeat	716..737	CDD:275380	4/20 (20%)
		LRRCT	751..800	CDD:214507	8/51 (16%)
		TIR	858..996	CDD:214587	42/149 (28%)
tlr7	NP_001427675.1	None