Protein Alignment Tl and tlr20.4

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: XP_073768827.1
• Gene: tlr20.4 / 100005571
• ZFINID: ZDB-GENE-071002-1
• Length: 457
• Species: Danio rerio
• Alignment Length: 477
• Identity: 120/477 - (25%)
• Similarity: 201/477 - (42%)
• Gaps: 90/477 - (18%)

  Fly   543 VHLGEGYNNNL-----VHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNV 602
            :||..|.|..|     :|:. ....:|.||..|....:|          ..:::...::|....:
Zfish    31 MHLVIGSNTTLNNGLNLHIK-GQYVIVEDCNSLLLTSVV----------TLQIQAAYMICENEFI 84

  Fly   603 LEGTP-VRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHK 666
            .:..| |..:|.|::     |:|:..:....... .|::|      :...:.:||:.|....:..
Zfish    85 GKYVPSVVSLEFQSM-----FADNIGDLSVINQL-VHLKT------LKLENIDLTNQPNTGIMFH 137

  Fly   667 NM-QLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSI--DVDQLPTNLTHLDISWNHLQM 728
            |: :|.::.|.|..:..|..:.|...:::|||.|......:|  :..:.||:|.:|     |.|.
Zfish   138 NLTKLEKMILMNCKIFFLDKSVTKDLKALTSLVLIPKEAVNIIQNFMEQPTHLKYL-----HFQC 197

  Fly   729 L-------NATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFER---IGDRNEMMCVN 783
            |       |..::.::....|...|  ..||.|.|     |...|.|..:.   |....|    |
Zfish   198 LDLYCSCDNTWLVSWIRDNGKVEVV--MSNPSMED-----LRCLTDDEVDHLNFISYAKE----N 251

  Fly   784 AEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFV 848
            ..:....|..|.:       .||:.:.:|:.|.....|    .|:|        .:.|....||
Zfish   252 CSIDLDFVFFSCS-------SVFLCIFIVVVLMYKFVG----QYFK--------PFYHIASGWF- 296

  Fly   849 TEEDLD-KDK---KFDAFISYSHKDQSFIEDYLVPQLE-HGPQKFQLCVHERDWLVGGHIPENIM 908
             .|.|. |:|   ::|||:|||.||:.::.:.|:|.|| .||...:||:|.||:.:|..|.|||.
Zfish   297 -REALRMKEKQQYRYDAFVSYSGKDEHWVIEELLPNLEQRGPPFLRLCLHSRDFQLGHDIVENIT 360

  Fly   909 RSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDI-GDVEKLDEELKAYL 972
            .|:..||||:.::|:|::.|.|..:|.:.|......|.|..:|::....| ..:......|...:
Zfish   361 DSIYASRRTLCLVSRNYLNSNWCSVEMQLATYRLQVEHRDILILVFLETIPSRLLSSHHRLARLV 425

  Fly   973 KMNTYLKW-GDP----WFWDKL 989
            |..|||.| .:|    .|||:|
Zfish   426 KTRTYLDWPQEPEMHEAFWDRL 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		LRR	222..576	CDD:443914	10/37 (27%)
		leucine-rich repeat	223..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..320	CDD:275380
		leucine-rich repeat	321..343	CDD:275380
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	368..391	CDD:275380
		leucine-rich repeat	392..415	CDD:275380
		leucine-rich repeat	416..439	CDD:275380
		leucine-rich repeat	440..474	CDD:275380
		leucine-rich repeat	475..498	CDD:275380
		leucine-rich repeat	499..520	CDD:275380
		leucine-rich repeat	523..552	CDD:275380	4/8 (50%)
		LRRCT	561..619	CDD:214507	10/58 (17%)
		LRRNT	631..667	CDD:214470	5/35 (14%)
		PPP1R42	<660..752	CDD:455733	21/101 (21%)
		leucine-rich repeat	664..693	CDD:275380	6/29 (21%)
		leucine-rich repeat	694..715	CDD:275380	6/22 (27%)
		leucine-rich repeat	716..737	CDD:275380	6/27 (22%)
		LRRCT	751..800	CDD:214507	12/51 (24%)
		TIR	858..996	CDD:214587	50/139 (36%)
tlr20.4	XP_073768827.1	None