Protein Alignment E(spl)m8-HLH and BHLHE40

DIOPT Version :10

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: NP_003661.1
• Gene: BHLHE40 / 8553
• HGNCID: 1046
• Length: 412
• Species: Homo sapiens
• Alignment Length: 176
• Identity: 46/176 - (26%)
• Similarity: 75/176 - (42%)
• Gaps: 36/176 - (20%)

  Fly    12 KVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQQKTPKKVA---- 72
            |:...::|::||.|:|:|:..||.|:.|      .|::.....||.||:.....|..|.:.
Human    54 KLPHRLIEKKRRDRINECIAQLKDLLPE------HLKLTTLGHLEKAVVLELTLKHVKALTNLID 112

  Fly    73 -QEEQSLPLDS------------------FKNGYMNAVNEVSRVMASTPGMSVDLGKS-VMTHLG 117
             |:::.:.|.|                  |.:|:.....||.:.:|.... :.||..| ::|||.
Human   113 QQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHEN-TRDLKSSQLVTHLH 176

  Fly   118 RVYKNLQQFHEAQSAADFIQNSMDCSSMDKAPLSPA--SSGYHSDC 161
            ||...|.|...::..:|.....||   ..:.|.|||  |.|...:|
Human   177 RVVSELLQGGTSRKPSDPAPKVMD---FKEKPSSPAKGSEGPGKNC 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	bHLH-O_ESM5_like	12..70	CDD:381486	17/57 (30%)
		ORANGE	81..125	CDD:128787	15/62 (24%)
BHLHE40	NP_003661.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer	1..139		21/90 (23%)
		bHLH-O_DEC1	40..129	CDD:381592	21/80 (26%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269|PubMed:19786558	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	14/44 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..303		12/41 (29%)