Protein Alignment E(spl)m8-HLH and Bhlhe40

DIOPT Version :10

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: NP_035628.1
• Gene: Bhlhe40 / 20893
• MGIID: 1097714
• Length: 411
• Species: Mus musculus
• Alignment Length: 223
• Identity: 48/223 - (21%)
• Similarity: 81/223 - (36%)
• Gaps: 67/223 - (30%)

  Fly     1 MEYTTKTQIYQ---------------KVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMD 50
            |::....|:|:               |:...::|::||.|:|:|:..||.|:.|      .|::.
Mouse    28 MDFAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPE------HLKLT 86

  Fly    51 KAEMLESAVIFMRQQKTPKKVA-----QEEQSLPLDS------------------FKNGYMNAVN 92
            ....||.||:.....|..|.:.     |:::.:.|.|                  |.:|:.....
Mouse    87 TLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGDLSGRNLEAGQEMFCSGFQTCAR 151

  Fly    93 EVSRVMASTPGMSVDLGKS-VMTHLGRVYKNLQQFHEAQSAADFIQNSMDCSSMDK--------- 147
            ||.:.:|.... :.||..| ::|||.||...|.|...::...|....::|......
Mouse   152 EVLQYLAKHEN-TRDLKSSQLVTHLHRVVSELLQGGASRKPLDSAPKAVDLKEKPSFLAKGSEGP 215

  Fly   148 ------------APLSPASSGYHSDCDS 163
                        ||.....||..:|.||
Mouse   216 GKNCVPVIQRTFAPSGGEQSGSDTDTDS 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	bHLH-O_ESM5_like	12..70	CDD:381486	17/57 (30%)
		ORANGE	81..125	CDD:128787	15/62 (24%)
Bhlhe40	NP_035628.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer. /evidence=ECO:0000250	1..139		24/116 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		bHLH-O_DEC1	40..129	CDD:381592	21/94 (22%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	14/44 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..294		7/17 (41%)