Protein Alignment E(spl)m3-HLH and HES5

DIOPT Version :10

• Sequence 1: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: XP_005244808.1
• Gene: HES5 / 388585
• HGNCID: 19764
• Length: 198
• Species: Homo sapiens
• Alignment Length: 249
• Identity: 54/249 - (21%)
• Similarity: 88/249 - (35%)
• Gaps: 81/249 - (32%)

  Fly     1 MVMEMSKTYQYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHV--TRLEKADILELTVD 63
            :.:|:....:..::.||::|:.||.|||..::.|| |::|  |:...|.  ::||||||||:.|.
Human     6 VAVELLSPKEKNRLRKPVVEKMRRDRINSSIEQLK-LLLE--QEFARHQPNSKLEKADILEMAVS 67

  Fly    64 HMRKLKQRGGLSLQGVVA---------GVGSPPTSTSTAHV---------ESFRSGYVHAADQIT 110
            :::..|.....:.:...:         ...|||.....|.|         :.:..||.....:..
Human    68 YLKHSKGERARAPRAPSSHRAPAPPRPAARSPPPRLPAAFVAAAGPKSLHQDYSEGYSWCLQEAV 132

  Fly   111 QVLLQTQQTDEIGRKIMKFLSTRLIELQTQLLQ--QQQQQQQHQQQQIPQSSGRLAFPLLGGYGP 173
            |.|.....:|                .|.:||.  |:.........:.|::.|....|.|.....
Human   133 QFLTLHAASD----------------TQMKLLYHFQRPPAAPAAPAKEPKAPGAAPPPALSAKAT 181

  Fly   174 AAAAAAISYSSFLTSKDELIDVTSVDGNALSETASVSSQESGASEP---VWRPW 224
            |||||                                     |.:|   :||||
Human   182 AAAAA-------------------------------------AHQPACGLWRPW 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m3-HLH	NP_524509.2	bHLH-O_ESMB_like	5..71	CDD:381584	24/67 (36%)
		ORANGE	96..136	CDD:128787	5/39 (13%)
HES5	XP_005244808.1	bHLH-O_HES5	18..74	CDD:381467	23/58 (40%)
		Hairy_orange	118..153	CDD:470640	8/50 (16%)