DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(spl)m3-HLH and HEY2

DIOPT Version :10

Sequence 1:NP_524509.2 Gene:E(spl)m3-HLH / 43156 FlyBaseID:FBgn0002609 Length:224 Species:Drosophila melanogaster
Sequence 2:NP_036391.1 Gene:HEY2 / 23493 HGNCID:4881 Length:337 Species:Homo sapiens


Alignment Length:298 Identity:58/298 - (19%)
Similarity:102/298 - (34%) Gaps:101/298 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 RKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGLSL 76
            ||..:.::|::||.|||..|.:|:.|:....:::|.  .:||||:||::||||::.|:..||   
Human    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS--AKLEKAEILQMTVDHLKMLQATGG--- 108

  Fly    77 QGVVAGVGSPPTSTSTAH---VESFRSGYVHAADQITQVLLQTQ---QTDEIGRKIMKFLSTRLI 135
            :|..           .||   ::....|:.....::.:.|...:   .:|.:..:::..|||...
Human   109 KGYF-----------DAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCAT 162

  Fly   136 ELQTQLLQQQQQQQQH-----------------------------------QQQQIPQSSG---- 161
            :.:...:........|                                   ...::|.:.|    
Human   163 QREAAAMTSSMAHHHHPLHPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALL 227

  Fly   162 ---------RLAFPLLGGYGP------------------AAAAAAISYSSFLTSKDELIDVTSVD 199
                     .|..|..|...|                  |||||..:..||..|......:...:
Human   228 TATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPN 292

  Fly   200 GNA-------------LSETASVSSQESGASEPVWRPW 224
            ..|             :|.|:|.....||.:...:|||
Human   293 AAAAVAAATAISPPLSVSATSSPQQTSSGTNNKPYRPW 330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(spl)m3-HLHNP_524509.2 bHLH-O_ESMB_like 5..71 CDD:381584 23/58 (40%)
ORANGE 96..136 CDD:128787 6/42 (14%)
HEY2NP_036391.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52 2/2 (100%)
bHLH-O_HEY2 40..121 CDD:381490 28/87 (32%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250 47..116 27/82 (33%)
ORANGE 119..165 CDD:128787 6/45 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 307..337 8/24 (33%)
YRPW motif 327..330 1/2 (50%)

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