Protein Alignment E(spl)mbeta-HLH and HEY1

DIOPT Version :10

• Sequence 1: NP_524505.2
• Gene: E(spl)mbeta-HLH / 43152
• FlyBaseID: FBgn0002733
• Length: 195
• Species: Drosophila melanogaster
• Sequence 2: NP_001035798.1
• Gene: HEY1 / 23462
• HGNCID: 4880
• Length: 308
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 64/266 - (24%)
• Similarity: 103/266 - (38%)
• Gaps: 98/266 - (36%)

  Fly    14 RKVMKPMLERKRRARINKCLDELKDIMVEC----LTQEGEHITRLEKADILELTVEHMKKLRAQK 74
            ||..:.::|::||.|||..|.||:.::...    :.::|.  .:||||:||::||:|:|.|.
Human    50 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGS--AKLEKAEILQMTVDHLKMLH--- 109

  Fly    75 QLRLSSVTGGVSPSADPKLSIAESFRA-GYVHAANEVSKTLAAVPGV--SVDLGTQLMSHL---- 132
                   |.|.....|.. ::|..:|: |:.....||::.|:.:.|:  |..|..:|:|||
Human   110 -------TAGGKGYFDAH-ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYA 166

  Fly   133 -------------------------------------GH----------------RLNYLQVVVP 144
                                                 ||                ||.......|
Human   167 SQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAP 231

  Fly   145 SL---PIGV--PLQAPVEDQAMVTPP-----------PSECDS---LESGACSP-APSEASSTSG 189
            :|   |.|.  |:...|...:.::||           |....|   |...|.|| ||::|::...
Human   232 ALRAPPSGSLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGK 296

  Fly   190 PMWRPW 195
            | :|||
Human   297 P-YRPW 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mbeta-HLH	NP_524505.2	bHLH-O_ESMB_like	7..75	CDD:381584	23/64 (36%)
		ORANGE	97..141	CDD:128787	16/103 (16%)
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		1/1 (100%)
		bHLH_SF	41..126	CDD:469605	27/88 (31%)
		ORANGE	124..170	CDD:128787	12/45 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..238		6/37 (16%)
		YRPW motif	298..301		1/2 (50%)