Protein Alignment E(spl)mdelta-HLH and HES4

DIOPT Version :10

• Sequence 1: NP_524503.2
• Gene: E(spl)mdelta-HLH / 43150
• FlyBaseID: FBgn0002734
• Length: 173
• Species: Drosophila melanogaster
• Sequence 2: NP_001135939.1
• Gene: HES4 / 57801
• HGNCID: 24149
• Length: 247
• Species: Homo sapiens
• Alignment Length: 192
• Identity: 52/192 - (27%)
• Similarity: 89/192 - (46%)
• Gaps: 47/192 - (24%)

  Fly    19 TKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANPQSP 83
            :||::|::||||:|..|.:||.||:|.:..:..:.||||||||||:||.:|::.::.:|....|.
Human    64 SKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSA 128

  Fly    84 PPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKFGTHLMKQLGHQLKDMKQEEEIIDMAEEPVN 148
            .|  ..|.|:|||:.:...||:...:...|:.....:.|   |||....::|    :..:..|.:
Human   129 DP--AVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRL---LGHLAACLRQ----LGPSRRPAS 184

  Fly   149 LADQKRSKSPREEDIHHGEEV-------------------------------------WRPW 173
            |:....:::|..| ::.|..:                                     ||||
Human   185 LSPAAPAEAPAPE-VYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGPWRPW 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	27/57 (47%)
		ORANGE	91..135	CDD:128787	11/43 (26%)
HES4	NP_001135939.1	bHLH-O_HES1_4	62..121	CDD:381465	27/56 (48%)
		Hairy_orange	135..174	CDD:462193	11/41 (27%)