Protein Alignment E(spl)mdelta-HLH and HES6

DIOPT Version :10

• Sequence 1: NP_524503.2
• Gene: E(spl)mdelta-HLH / 43150
• FlyBaseID: FBgn0002734
• Length: 173
• Species: Drosophila melanogaster
• Sequence 2: NP_061115.2
• Gene: HES6 / 55502
• HGNCID: 18254
• Length: 224
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 58/224 - (25%)
• Similarity: 90/224 - (40%)
• Gaps: 81/224 - (36%)

  Fly    11 KTQHYRKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYL------ 69
            :|:..||..|||:|:|||||:|..|.||:.|:     |..|..:|||.|::|||||..:
Human    21 ETRGDRKARKPLVEKKRRARINESLQELRLLL-----AGAEVQAKLENAEVLELTVRRVQGVLRG 80

  Fly    70 KAQQQQRVANPQSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKFGTHLMKQLGHQLKDMK 134
            :|::::::....|        ::|.|||.|..:||....||...:|......|   |.|.|:.|.
Human    81 RAREREQLQAEAS--------ERFAAGYIQCMHEVHTFVSTCQAIDATVAAEL---LNHLLESMP 134

  Fly   135 QEE-----EII--------------------------------------DMAEEPVNLADQKRSK 156
            ..|     :::                                      |:.|.|    :.:.|:
Human   135 LREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAP----EAELSQ 195

  Fly   157 SPRE-EDI-----------HHGEEVWRPW 173
            :|.| .|:           .....|||||
Human   196 APAEGPDLVPAALGSLTTAQIARSVWRPW 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	29/71 (41%)
		ORANGE	91..135	CDD:128787	15/43 (35%)
HES6	NP_061115.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		3/9 (33%)
		bHLH_SF	24..81	CDD:469605	27/61 (44%)
		Hairy_orange	95..134	CDD:462193	14/41 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..205		7/61 (11%)
		WRPW motif	221..224		2/2 (100%)