Protein Alignment E(spl)mdelta-HLH and HES5

DIOPT Version :10

• Sequence 1: NP_524503.2
• Gene: E(spl)mdelta-HLH / 43150
• FlyBaseID: FBgn0002734
• Length: 173
• Species: Drosophila melanogaster
• Sequence 2: XP_005244808.1
• Gene: HES5 / 388585
• HGNCID: 19764
• Length: 198
• Species: Homo sapiens
• Alignment Length: 190
• Identity: 49/190 - (25%)
• Similarity: 81/190 - (42%)
• Gaps: 42/190 - (22%)

  Fly    17 KVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANP- 80
            ::.||::|:.||.|:|..:::|| |:::...|:.:..||||||||||:.|:|||..:.:|...|
Human    18 RLRKPVVEKMRRDRINSSIEQLK-LLLEQEFARHQPNSKLEKADILEMAVSYLKHSKGERARAPR 81

  Fly    81 ---------------QSPP------------PDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKF 118
                           :|||            |..::.| :..||:....|.....:.....|.:
Human    82 APSSHRAPAPPRPAARSPPPRLPAAFVAAAGPKSLHQD-YSEGYSWCLQEAVQFLTLHAASDTQ- 144

  Fly   119 GTHLMKQLGHQLKD-----MKQEEEIIDMAEEPVNLADQKRSKSPREEDIHHGEEVWRPW 173
                ||.|.|..:.     ...:|.....|..|..|:.:..:.:........|  :||||
Human   145 ----MKLLYHFQRPPAAPAAPAKEPKAPGAAPPPALSAKATAAAAAAHQPACG--LWRPW 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	25/59 (42%)
		ORANGE	91..135	CDD:128787	9/48 (19%)
HES5	XP_005244808.1	bHLH-O_HES5	18..74	CDD:381467	25/56 (45%)
		Hairy_orange	118..153	CDD:470640	9/40 (23%)