Protein Alignment E(spl)mdelta-HLH and Hey1

DIOPT Version :10

• Sequence 1: NP_524503.2
• Gene: E(spl)mdelta-HLH / 43150
• FlyBaseID: FBgn0002734
• Length: 173
• Species: Drosophila melanogaster
• Sequence 2: NP_034553.2
• Gene: Hey1 / 15213
• MGIID: 1341800
• Length: 299
• Species: Mus musculus
• Alignment Length: 164
• Identity: 41/164 - (25%)
• Similarity: 68/164 - (41%)
• Gaps: 39/164 - (23%)

  Fly    16 RKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANP 80
            ||..:.::|::||.|:|..|.||:.|:....:.||.  :|||||:||::||::||  ........
Mouse    50 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTVDHLK--MLHTAGGK 110

  Fly    81 QSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLD------LKFGTHLMKQLGHQLKDMKQEEEI 139
            .......:.:|....|:.:...||:...|.:.|||      ::..:||.
Mouse   111 GYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLN---------------- 159

  Fly   140 IDMAEEPVNLADQKRSKSPREEDIHHGEEVWRPW 173
                    |.|.|:.:.|.....:.|     .||
Mouse   160 --------NYASQREAASGAHGGLGH-----IPW 180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	24/60 (40%)
		ORANGE	91..135	CDD:128787	10/49 (20%)
Hey1	NP_034553.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		2/2 (100%)
		bHLH_SF	41..122	CDD:469605	24/75 (32%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	48..117		24/70 (34%)
		ORANGE	120..166	CDD:128787	13/69 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..234
		YRPW motif	289..292