Protein Alignment CG5112 and FAAH

DIOPT Version :10

• Sequence 1: NP_651400.1
• Gene: CG5112 / 43083
• FlyBaseID: FBgn0039341
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001432.2
• Gene: FAAH / 2166
• HGNCID: 3553
• Length: 579
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 134/549 - (24%)
• Similarity: 211/549 - (38%)
• Gaps: 124/549 - (22%)

  Fly    41 PSLEQQTTITKSAVELAQQIRERRQRSYDIVKAYCERIESVNRDLNAVVDGPFPEALDQAREIDR 105
            |.|:.:..:.....:|.|::..|......::..|..:...||:..|.|.        ....:.:.
Human    67 PDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVT--------SYLADCET 123

  Fly   106 KLDEKEYSDEDLRRLPFLGVPFSTKDSTAVAGRLHTLGLLARKSERSTTDAECVRLMKESGAIII 170
            :|.:..      |:....|||.|.|:.....|:..||||...:...:..|:..|.::|..||:..
Human   124 QLSQAP------RQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPF 182

  Fly   171 ATSNVPEVNKWIESRNMLIGCTNNPYDLRRSVGGSSGGEAALIAACCTGFGLGTDIGGSIRIPAF 235
            ..:|||:.....:..|.|.|.|.||:...:|.|||||||.|||.:..:..|||||||||||.|:.
Human   183 VHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSS 247

  Fly   236 NCGIFGHKPTSGAVN---MAGCTFRTGKEKDTMVCAGPMSRSARDLLPMMQVLVEPSLKAKLKLD 297
            .|||.|.|||...::   :.||.:  |:|. ..:..|||:|....|...::.|:   .:...:||
Human   248 FCGICGLKPTGNRLSKSGLKGCVY--GQEA-VRLSVGPMARDVESLALCLRALL---CEDMFRLD 306

  Fly   298 QKV-----------DLKRLRYFYVSSNGMAQCNPINRETERVMYKIRKHFEAVSGKDVRHADLPY 351
            ..|           ..:.||..|..::.....:|..|   |.:.:.::..||..     |..:|:
Human   307 PTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMR---RAVLETKQSLEAAG-----HTLVPF 363

  Fly   352 ----------TKLTGKMWRYWMTQEPANFNLLLGNGAELNPFVELFKKILGQSDYSMAAIYGLID 406
                      |..||.::.........||     .|..::|.:.....||....:....:..|:.
Human   364 LPSNIPHALETLSTGGLFSDGGHTFLQNF-----KGDFVDPCLGDLVSILKLPQWLKGLLAFLVK 423

  Fly   407 SVLPK-------------------EKEKLMREATAKCKKSVQDLLGDDGVLFFHSSPRTAPFHYY 452
            .:||:                   :.|..:...|...:....||   |.||    :|..|
Human   424 PLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDL---DVVL----TPMLA----- 476

  Fly   453 PLVKFN-------DFAYFSLFNVLHLPATQVPM----------------------------GL-D 481
            |.:..|       ..:|..|:|.|..||..||:                            |: .
Human   477 PALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKK 541

  Fly   482 SKGMPLGIQVVANPNNDRLCLAVAEELER 510
            |.|:|:.:|.||.|..:.|||....|:||
Human   542 SVGLPVAVQCVALPWQEELCLRFMREVER 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5112	NP_651400.1	GatA	50..520	CDD:439924	132/540 (24%)
FAAH	NP_001432.2	Amidase	95..562	CDD:396144	124/511 (24%)