Protein Alignment rha and CEP120

DIOPT Version :10

• Sequence 1: NP_651390.2
• Gene: rha / 43071
• FlyBaseID: FBgn0027376
• Length: 1332
• Species: Drosophila melanogaster
• Sequence 2: NP_694955.2
• Gene: CEP120 / 153241
• HGNCID: 26690
• Length: 986
• Species: Homo sapiens
• Alignment Length: 1375
• Identity: 249/1375 - (18%)
• Similarity: 454/1375 - (33%)
• Gaps: 516/1375 - (37%)

  Fly    30 SDQVYCVLLHVVEAINFIGRDATDRQQIVMNAALNSVDFEVEGTQSEETIIFNSNCIWECDLAGI 94
            |||: .:::.::|..:|..|   .:..:|:.|..:......:.....:...|.:...||.|...:
Human     5 SDQL-LIVVSILEGRHFPKR---PKHMLVVEAKFDGEQLATDPVDHTDQPEFATELAWEIDRKAL 65

  Fly    95 KRLKTDHRPVKMTFYACRGGGAERKTIGTLLLPVRGLPVLGTVGSHNSPHLKMFWHKLICTSSEF 159
            .:.:....|:|:..:|.....:.::|||.::|.:|     ....:..:|.    |::|:  |:::
Human    66 HQHRLQRTPIKLQCFALDPVTSAKETIGYIVLDLR-----TAQETKQAPK----WYQLL--SNKY 119

  Fly   160 RSHKPEVLLMLTIIKKSILHTKDFEHFMQFTEVKSP-------PTPPMQSPGHSITA-------- 209
            ...|.|:.:.:.:                .|:.|.|       ..||......:|.|
Human   120 TKFKSEIQISIAL----------------ETDTKPPVDSFKAKGAPPRDGKVPAILAGLDPRDIV 168

  Fly   210 SMLQSQANVYVQSLVQLGLLQVGNDPLVDCDIIEVVLQLKQLRNVTGLVKSLNQGKPPSSVILVF 274
            ::|..:...:     |:|..:...|..:....|....||:||...|   ..|.:.:|  .....:
Human   169 AVLNEEGGYH-----QIGPAEYCTDSFIMSVTIAFATQLEQLIPCT---MKLPERQP--EFFFYY 223

  Fly   275 DFVGN-VTNIELKLNESDTYTLNDVL---------GLRFKTSLRSMRLYFQRIFYLPINMYMNGT 329
            ..:|| |||          ...||::         .:|.::|:..:|:|......|.|::.....
Human   224 SLLGNDVTN----------EPFNDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLCCGDQ 278

  Fly   330 AIAHYRMDFTNLLPADDFFSDNRKYTSNGSFSFNRFGRTDSGREPKPPLMEYTFSV--------- 385
            ::....:..|.||.......:....|..|:|:.:...|......|.|..:..|..|
Human   279 SLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIPVELAPTVGVSVALQREGI 343

  Fly   386 ------DLKTIFSRQEQEEPER------TPSIASGNLDSEDEQYLG-QTFCASVVRSRLNLNESE 437
                  :|||    |.:.|||.      ||        .:::...| ::...|.|.|.   |:|.
Human   344 DSQSLIELKT----QNEHEPEHSKKKVLTP--------IKEKTLTGPKSPTVSPVPSH---NQSP 393

  Fly   438 ETDEIASNVMKQLANDSETEVIEMKSNTK-NSKHNTS-PQRKSQESKKLIRESSRNTRNSLENLQ 500
            .|        |..|.:||.|.::...:|| |.|.::| |...:|                |....
Human   394 PT--------KDDATESEVESLQYDKDTKPNPKASSSVPASLAQ----------------LVTTS 434

  Fly   501 NVDELTSLDLFELEEKRQEKIA------------ELERIKA------------------GQSESL 535
            |..|:.|          .:|||            :|..|.|                  |.:..:
Human   435 NASEVAS----------GQKIAVPATSHHFCFSIDLRSIHALEIGFPINCILRYSYPFFGSAAPI 489

  Fly   536 L-QTELKVKKHKKADL--------------ELQGKKSQLETINEVPPKSLRKSKP----VSQSEL 581
            : ...::|:|:.:..|              :||....::..:.|:..|. :.||.    :::.:|
Human   490 MTNPPVEVRKNMEVFLPQSYCAFDFATMPHQLQDTFLRIPLLVELWHKD-KMSKDLLLGIARIQL 553

  Fly   582 NNV------------------PKIQENLPILNNQTKGSRIQKENCEENNEDLSYALSEEHSSSNE 628
            :|:                  ....|::|::..|...:||         .||||.::.|..
Human   554 SNILSSEKTRFLGSNGEQCWRQTYSESVPVIAAQGSNNRI---------ADLSYTVTLEDY---- 605

  Fly   629 KLDKKPGASKTMRPPEHVDTDLETDISVFSIQKKRKSKSKLVISNELHNFEDSSTDTLEKGRPNP 693
                  |..| ||  |...:|....:|  ::|:|..|..                       |.|
Human   606 ------GLVK-MR--EIFISDSSQGVS--AVQQKPSSLP-----------------------PAP 636

  Fly   694 SKGDLKLRARWVEVNKVQTQALIETEKFLQKTCPAELDEVLYEDQVALGQAKTSKPTKRKVKKPE 758
            ...:::...|    ..::.:|.:|.|.:      .|:.|.::|:|:...:....:....:.||.:
Human   637 CPSEIQTEPR----ETLEYKAALELEMW------KEMQEDIFENQLKQKELAHMQALAEEWKKRD 691

  Fly   759 EDKVKRIDYETSYEEEITFCHPEKDPMTMIGENPINLNDLASSEEYISISEGNSKPAEIVYTETE 823
            .::      |:..::::.                          || :|.||..:...|...:.|
Human   692 RER------ESLVKKKVA--------------------------EY-TILEGKLQKTLIDLEKRE 723

  Fly   824 QRVTFVNPKRDREKKKLSSLSKDDLLVEVRSEEYINLRSSARSKTDCVRKKKKISIHEDQVYQAE 888
            |::..|..:..||||            |::||...||    :...|.:|:.|     ||.::|.|
Human   724 QQLASVESELQREKK------------ELQSERQRNL----QELQDSIRRAK-----EDCIHQVE 767

  Fly   889 LTPSEEPSSQSESRGTDNANPITDQPQVDRVKKKKRDTSGDQQLFHVEYTSSQKSISKTEGNVKC 953
            |                           :|:|.|:
Human   768 L---------------------------ERLKIKQ------------------------------ 775

  Fly   954 KELIEPDVEQTDVQVLKKKKLKKTLVTNDTVAQDYETLEEETIKPVKKKIVRKKSSVILEKIEDT 1018
               :|.|          |.:|::.|  || ....|:.||:|                 .::.:|.
Human   776 ---LEED----------KHRLQQQL--ND-AENKYKILEKE-----------------FQQFKDQ 807

  Fly  1019 ENKGPADEVVSVEAKKIIKKKAKPACDNPTVEEYPKTKKGESRKLKSTSKEHFTMEKPSSTIDSI 1083
            :|..|...:.| |...:            |:|:....:|.||   .:.||.|:..:
Human   808 QNNKPEIRLQS-EINLL------------TLEKVELERKLES---ATKSKLHYKQQ--------- 847

  Fly  1084 GQKIKSWRRQQIDLFEQELARKEMHYIKQLEQMESQEARLHQLHKADTNLDETFISKIPNVSEVD 1148
                  |.|          |.||:..:||.|| |||.||   |.|....|::
Human   848 ------WGR----------ALKELARLKQREQ-ESQMAR---LKKQQEELEQ------------- 879

  Fly  1149 YEAKFTELEEHIALLKSEMEEQVRLFENRSRELRQENLQLYSEKTELKVRIAALEQQIGDLKAQG 1213
            ...::...||. ..:|:|.:|.:.: .|....|||:..:.|.:.||:               |.|
Human   880 MRLRYLAAEEK-DTVKTERQELLDI-RNELNRLRQQEQKQYQDSTEI---------------ASG 927

  Fly  1214 SDEGDLKEVLGELRSQHYRYNNLAREKELFRKRWRRSAKRVHALKLAMYERSLEREHSNIRVEPI 1278
            ..:|....||.|....:  ...|..|::..             ::..:|      .|.:..:..:
Human   928 KKDGPHGSVLEEGLDDY--LTRLIEERDTL-------------MRTGVY------NHEDRIISEL 971

  Fly  1279 D--LRKILTK 1286
            |  :|:||.|
Human   972 DRQIREILAK 981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rha	NP_651390.2	DUF3668	158..387	CDD:463569	45/268 (17%)
		PTZ00108	<473..775	CDD:240271	58/369 (16%)
		COG4913	<1092..>1307	CDD:443941	43/197 (22%)
CEP120	NP_694955.2	C2	9..114	CDD:472691	19/116 (16%)
		DUF3668	118..340	CDD:463569	45/257 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..424		26/96 (27%)
		Smc	<669..>923	CDD:440809	85/457 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..937		6/37 (16%)