Protein Alignment Nepl16 and ECEL1

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_004817.2
• Gene: ECEL1 / 9427
• HGNCID: 3147
• Length: 775
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 152/739 - (20%)
• Similarity: 263/739 - (35%)
• Gaps: 195/739 - (26%)

  Fly   150 SAPPECSDPICEA-VASSIQARLNWNKDPCTEFKKFSC--W---RNTPNKNIT--NLIEMGNSQK 206
            :.|..|.:....| .|..:.|.|:.:.|||.:|..|:|  |   ...|:..:|  .:..:|...:
Human    94 ACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNE 158

  Fly   207 SVDSQMLY--------LFQNKIMNGSFGILHNLFESCLQ----QTTNSTVMHRIFDSLGGYLPVG 259
            ....::|.        ..|.|:        ...|.|||.    :......|..:.:..||:
Human   159 ERLRRLLARPGGGPGGAAQRKV--------RAFFRSCLDMREIERLGPRPMLEVIEDCGGW---- 211

  Fly   260 SVGPSSIAPLIAKIYDL-----------GPSPLVDLYHDLSYGRRPHILLIISGPSTSSTILERK 313
            .:|.:...|.:|..:||           ..:.|..|  .:|...|.....:|.......|:.||.
Human   212 DLGGAEERPGVAARWDLNRLLYKAQGVYSAAALFSL--TVSLDDRNSSRYVIRIDQDGLTLPERT 274

  Fly   314 IRWMSPKAPPSRI-------RQGVPKLL-ADLIENFLPYFVSYAQRVSEKDTIFEFIKDLNKLQV 370
            : :::......:|       .:.|..|| ||.:|          |:..|   |.:..:.|..:.|
Human   275 L-YLAQDEDSEKILAAYRVFMERVLSLLGADAVE----------QKAQE---ILQVEQQLANITV 325

  Fly   371 -EHS--RRGFWDSTVLYN---VSSLQDLYPVLNWTLLIPQ------NWSGPIVVRNSDYLKALEY 423
             ||.  ||   |.:.:||   :..||.:.|.|.|..|:.|      :....:|:..:||::.:..
Human   326 SEHDDLRR---DVSSMYNKVTLGQLQKITPHLRWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQ 387

  Fly   424 FLTKYPTRVAHNSL-----LLLS---------ALQILPRDYPSPE-------VCTRSTMWALPEL 467
            .:...|.||.||.|     ::||         ||..|.::....:       ||...........
Human   388 LIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANRHFGMA 452

  Fly   468 SSSLYIAQHSSEDLKDTTKRAEIIFKSLKAHL-KRAPSL-------KGAALVKLSALKIQSQTWE 524
            ..:|::.:|.|...|   .:.:.:.:.:|..| :|...|       :.||..||..:.:. ..:.
Human   453 LGALFVHEHFSAASK---AKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVM-VGYP 513

  Fly   525 GFSNTTDLLKSLQPLNITSECWFQNIL----------------EIYKKNKLEPNDISLNGGSHDA 573
            .|....|.:.......:..:.:|:|||                |:.|...|.|
Human   514 DFLLKPDAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLP------------ 566

  Fly   574 WAYPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSITKSFDE---- 634
               |.....:|....:.:|.|..::....::...|..|:|..:|..|..|    :|..:|:
Human   567 ---PQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHE----LTHGYDDWGGQ 624

  Fly   635 --------------------KAMRCVPHSVNIFSNYSRM--------DILIHSGGMQISYHSMLS 671
                                :...|:....:.|:.|::.        :.:...||::::||:...
Human   625 YDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQK 689

  Fly   672 LT---GPIKGMARLPGLNLTPTQIFFLVSAQELC----AESNYLGI--DTNAPEFDNILGWLVAQ 727
            ..   ||   ...||.|..|..|:||:..||..|    ::|.||.:  |.:|||...:|| .|:|
Human   690 WVREHGP---EHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLG-SVSQ 750

  Fly   728 GGSATEVFKCPSGSMINVQKTCNV 751
            .......|.||..|.:|....|:|
Human   751 FEEFGRAFHCPKDSPMNPAHKCSV 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	144/709 (20%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	144/710 (20%)