DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and PHEX

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	792	Identity:	152/792 - (19%)
Similarity:	269/792 - (33%)	Gaps:	247/792 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPE-CSDPICEAVASSIQARLNWNKDPCTEF 181
            ||...||||:|.....|               .|..| |..|.|...|::|.:::|.:.|||..|
Human    31 LVLGTILFLVSQGLLSL---------------QAKQEYCLKPECIEAAAAILSKVNLSVDPCDNF 80

  Fly   182 KKFSC--------------------W-RNTPNKNITNLIEMGNSQKSVDSQMLYLFQNKIMNGSF 225
            .:|:|                    | |:..:..:..|:|...|::. |::.:.  :.||:..|.
Human    81 FRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRR-DTEAIQ--KAKILYSSC 142

  Fly   226 GILHNLFESCLQQTTNSTVMHRIFDSLGGYLPV--GSVGPSSIAPLIAKIYDLGPSPLVDLYHDL 288
                 :.|..:::.....::|.:..|...: ||  .::||..:
Human   143 -----MNEKAIEKADAKPLLHILRHSPFRW-PVLESNIGPEGV---------------------- 179

  Fly   289 SYGRRPHILL----IISGPSTSSTILERKIRWMSPKAPPS-----RIRQGVPKLLA--DLIENFL 342
             :..|...||    ...|..::|..:.   .::||....|     ::.|....|..  |.::|
Human   180 -WSERKFSLLQTLATFRGQYSNSVFIR---LYVSPDDKASNEHILKLDQATLSLAVREDYLDN-- 238

  Fly   343 PYFVSYAQRVSEKDTIFEFIKD------LNKLQVEHSRRGFW----------------DSTVLY- 384
                 ..:..|.:|.:::|:.|      .|..:.||..:...                .|..:|
Human   239 -----STEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYN 298

  Fly   385 --NVSSLQDLYPVLNW---------TLLIPQ----NWSGPIVVRNSDYLKALEYFLTKYPTRVAH 434
              |:|.|..:.|..:|         |.|.|.    :.|..:|||...|.|.|...|.....:...
Human   299 KMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIA 363

  Fly   435 NSL---LLLSALQILPRDY------------------PSPEVCTRSTMWALPELSSSLYIAQHSS 478
            |.|   ::.|.:..|.|.:                  |..:.|......|||.:...:::..:..
Human   364 NYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQ 428

  Fly   479 EDLKDTTKR---------AEIIFKS---LKAHLKRAPSLKG-AALVKLSALKIQSQTWEGFSNTT 530
            ||.|:..:.         .:::.|.   :.|..||....|. |.|.|:...       |...|.|
Human   429 EDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYP-------EFIMNDT 486

  Fly   531 DLLKSLQPLNITSECWFQNILEIYK---------KNKLEPNDISLNGGSHDAWAYPIVSTIFYDT 586
            .:.:.|:.:..:...:|.|:|:..|         ..|..|..        :.:..|.....||..
Human   487 HVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKT--------EWFTNPTTVNAFYSA 543

  Fly   587 LSHSIVVPLSVILIPYF-NAVLPPYLHYASVGVSIAKEILRSI------------------TKS- 631
            .::.|..|...:..|:| ....|..|.|.::||.:..|.....                  |:|
Human   544 STNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESE 608

  Fly   632 --FDEKAMRCVPHSVNIFSNY----SRMDI---------LIHSGGMQISYHS--------MLSLT 673
              |.||. :|:   :|.:|||    :.:::         :..:||::.::.:        ...|.
Human   609 EKFKEKT-KCM---INQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLE 669

  Fly   674 GPIKGMARLPGLNLTPTQIFFLVSAQELC------AESNYLGIDTNAPEFDNILGWLVAQGGSAT 732
            .|:     |||:..|..|:|||..|...|      |....:.|..::|....:.| .::......
Human   670 EPL-----LPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNG-AISNFEEFQ 728

  Fly   733 EVFKCPSGSMIN 744
            :.|.||..|.:|
Human   729 KAFNCPPNSTMN 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	136/733 (19%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	136/734 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910