Protein Alignment Nepl16 and PHEX

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 792
• Identity: 152/792 - (19%)
• Similarity: 269/792 - (33%)
• Gaps: 247/792 - (31%)

  Fly   118 LVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPE-CSDPICEAVASSIQARLNWNKDPCTEF 181
            ||...||||:|.....|               .|..| |..|.|...|::|.:::|.:.|||..|
Human    31 LVLGTILFLVSQGLLSL---------------QAKQEYCLKPECIEAAAAILSKVNLSVDPCDNF 80

  Fly   182 KKFSC--------------------W-RNTPNKNITNLIEMGNSQKSVDSQMLYLFQNKIMNGSF 225
            .:|:|                    | |:..:..:..|:|...|::. |::.:.  :.||:..|.
Human    81 FRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRR-DTEAIQ--KAKILYSSC 142

  Fly   226 GILHNLFESCLQQTTNSTVMHRIFDSLGGYLPV--GSVGPSSIAPLIAKIYDLGPSPLVDLYHDL 288
                 :.|..:::.....::|.:..|...: ||  .::||..:
Human   143 -----MNEKAIEKADAKPLLHILRHSPFRW-PVLESNIGPEGV---------------------- 179

  Fly   289 SYGRRPHILL----IISGPSTSSTILERKIRWMSPKAPPS-----RIRQGVPKLLA--DLIENFL 342
             :..|...||    ...|..::|..:.   .::||....|     ::.|....|..  |.::|
Human   180 -WSERKFSLLQTLATFRGQYSNSVFIR---LYVSPDDKASNEHILKLDQATLSLAVREDYLDN-- 238

  Fly   343 PYFVSYAQRVSEKDTIFEFIKD------LNKLQVEHSRRGFW----------------DSTVLY- 384
                 ..:..|.:|.:::|:.|      .|..:.||..:...                .|..:|
Human   239 -----STEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYN 298

  Fly   385 --NVSSLQDLYPVLNW---------TLLIPQ----NWSGPIVVRNSDYLKALEYFLTKYPTRVAH 434
              |:|.|..:.|..:|         |.|.|.    :.|..:|||...|.|.|...|.....:...
Human   299 KMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIA 363

  Fly   435 NSL---LLLSALQILPRDY------------------PSPEVCTRSTMWALPELSSSLYIAQHSS 478
            |.|   ::.|.:..|.|.:                  |..:.|......|||.:...:::..:..
Human   364 NYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQ 428

  Fly   479 EDLKDTTKR---------AEIIFKS---LKAHLKRAPSLKG-AALVKLSALKIQSQTWEGFSNTT 530
            ||.|:..:.         .:::.|.   :.|..||....|. |.|.|:...       |...|.|
Human   429 EDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYP-------EFIMNDT 486

  Fly   531 DLLKSLQPLNITSECWFQNILEIYK---------KNKLEPNDISLNGGSHDAWAYPIVSTIFYDT 586
            .:.:.|:.:..:...:|.|:|:..|         ..|..|..        :.:..|.....||..
Human   487 HVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKT--------EWFTNPTTVNAFYSA 543

  Fly   587 LSHSIVVPLSVILIPYF-NAVLPPYLHYASVGVSIAKEILRSI------------------TKS- 631
            .::.|..|...:..|:| ....|..|.|.::||.:..|.....                  |:|
Human   544 STNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESE 608

  Fly   632 --FDEKAMRCVPHSVNIFSNY----SRMDI---------LIHSGGMQISYHS--------MLSLT 673
              |.||. :|:   :|.:|||    :.:::         :..:||::.::.:        ...|.
Human   609 EKFKEKT-KCM---INQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLE 669

  Fly   674 GPIKGMARLPGLNLTPTQIFFLVSAQELC------AESNYLGIDTNAPEFDNILGWLVAQGGSAT 732
            .|:     |||:..|..|:|||..|...|      |....:.|..::|....:.| .::......
Human   670 EPL-----LPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNG-AISNFEEFQ 728

  Fly   733 EVFKCPSGSMIN 744
            :.|.||..|.:|
Human   729 KAFNCPPNSTMN 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	136/733 (19%)
PHEX	NP_000435.3	M13	74..740	CDD:341056	135/732 (18%)