DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and goe

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_001285350.1	Gene:	goe / 32660	FlyBaseID:	FBgn0027528	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	778	Identity:	145/778 - (18%)
Similarity:	265/778 - (34%)	Gaps:	244/778 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 ITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVASSIQARL 171
            :|:|.|....||:   |:.|::..|.             .|.....|.|.|..|  |.||.|..|
  Fly   131 VTTACLCALLLLI---IILLLAFWPE-------------VPFYLRAPLCLDKEC--VESSRQLLL 177

  Fly   172 --NWNKDPCTEFKKFSC-------------------WRNTPNKNITNLIEMG-------NSQK-S 207
              |.:|.||.|..:::|                   |..........|.|:.       |||: |
  Fly   178 WANTSKSPCHETYEWACGNFASDYANHEYFVIKRGEWNYETYNEYQELNELNRFIAMLPNSQEGS 242

  Fly   208 VDSQMLYLFQNKIMNGSFGILHNLFESC-----LQQTTNSTVMHRIFDSLGGYLP------VGSV 261
            |:|                .:.:|:.||     |.::.:..::.|..:::.|:..      :.|.
  Fly   243 VES----------------TVSSLYRSCRETDVLDKSQSDLLLKRAINAVYGWQAFRDSNRLQSW 291

  Fly   262 GPSSIAPLIAKIYDLGPSPLVDLYHDLSYGRRPHILLIISGPSTSSTILERKI----RWMSPKAP 322
            ....:..::...:.:.|...|.:.:..|   .||..:|        |:.|.::    ::......
  Fly   292 EYKRVLVVLQAKHGIFPYYRVTVENGFS---NPHDYVI--------TLDEGELGLPDKYFYGNDA 345

  Fly   323 PSRIRQGVPKLLADLIEN----------FLPYFVSYAQRVSE--KDTIFEFIKDLNK------LQ 369
            ...:.:|...||.|...|          |......|.:|:..  :|...:..:.:||      |:
  Fly   346 DEEVVRGYKLLLRDFAINMGIVSREADLFADDIFHYERRIVNHIEDAKADANRPINKLMRLADLK 410

  Fly   370 VEHSRRGFWDSTVLYNVSSLQDLYPVLNWTLLIPQNWSGPIVVRNSDYLKALEYFLTKYPTRVAH 434
            ::        :..|..:.|||.::|....|      ....::||:.:.:.||...|:....:..:
  Fly   411 IK--------APSLPILESLQAIFPKTKIT------EDTEVLVRDPEVMHALSVLLSTSDKKPIN 461

  Fly   435 NSLLLLSALQILPR---------------------DYPSPEVCTRSTMWALPELSSSLYIAQHSS 478
            |.::...|.::||.                     .||...:|::.....||....:|. .|...
  Fly   462 NFIVWSLARKMLPHLSKEYRTLAETFDHALYGRTASYPRWLICSKVVRDWLPFAVDALQ-QQPPR 525

  Fly   479 EDLKDTTKRA-------------EIIFKSLKAHLKRA--------PSLKGAALVKLSALKIQ--- 519
            :..:..|.::             :::|.||:..||.:        |:.:.....||:.:::|
  Fly   526 QQFETMTSKSRGLNKTQGNEELLKLMFFSLRNQLKDSLEQAKWLEPAARQFIQKKLNEMRLQFGI 590

  Fly   520 ---------------------------SQTWEGFSNTTDLLKSLQPLN----ITSECWF----QN 549
                                       ...|......:.:.|.|.||.    |.||.:.    |.
  Fly   591 PDEVLQQPTYLAQYYNELILNNVFFVEHLEWIWTFRRSQMEKKLGPLAILDVIVSEMYTRDNPQA 655

  Fly   550 ILEIYKKNKLEPNDISLNGGSHDAWAYPIV---STIFYDTLSHSIVVPLSVILIPYFN------A 605
            |....|.|.|..:.:.::...:| :.||:.   :.|..|.| .:::...|..|: .||      :
  Fly   656 IAYSNKLNMLLVSKVLISSNYYD-YRYPVAVNFARIGTDIL-EALIDNFSTFLL-QFNTQSTDIS 717

  Fly   606 VLPPYLHYASVGVS----------------IAKEILRS--ITKSFDEKAMRCVPHSVNIFSNYSR 652
            ...|.:.||...|:                ::...|:|  :|.|....|.|.:.:.||.....|.
  Fly   718 DAAPEIRYAQPDVNCLAAGQPPRLVHELNELSSNALKSFHVTLSAARTAARALSNFVNAIDAGSA 782

  Fly   653 MDILIHSGGMQISYHSMLSLTGPIKGMARLPGL-NLTPTQIFFLVSAQELC----AESNYLGI 710
            :.   .||..|.:.:..|.||..:    |:||| :....::|.|...|:.|    |:.:|..|
  Fly   783 IQ---GSGIDQANTYEALGLTRRL----RIPGLRSFNENELFTLSYMQQHCSTTIADKDYARI 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	125/707 (18%)
goe	NP_001285350.1	GluZincin	184..>694	CDD:301352	89/552 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910