Protein Alignment Nepl16 and nep-18

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_494297.1
• Gene: nep-18 / 186911
• WormBaseID: WBGene00019343
• Length: 701
• Species: Caenorhabditis elegans
• Alignment Length: 758
• Identity: 146/758 - (19%)
• Similarity: 250/758 - (32%)
• Gaps: 237/758 - (31%)

  Fly   151 APPECSDPICEAVASSIQARLNWNKDPCTEFKKFSCWRNTPNKNITNLIEMGNSQKSVD-SQMLY 214
            :|..|....|..|.:.|:...|.:.|||.:|.:.:|.|.:.:      :...||...|. .|:||
 Worm    23 SPETCWSKECVGVLAMIKNYQNASVDPCEDFFEHTCGRYSEH------VMDDNSWGYVQYKQLLY 81

  Fly   215 -LF-----QNKIMNGSFGILHNLFESCL--QQTTNSTV--MHRIFDSLGGYLPVGSVGPS----- 264
             :|     .||..:.....|....:|||  ::....|.  :....:..||: |:  :.|:
 Worm    82 QVFAIARKTNKFNSKPNEQLRIFTKSCLDRKEMDEDTFQDLRNDIEERGGF-PM--IDPNWNEEK 143

  Fly   265 -SIAPLIAKIYDLGPSPL----VDLYHDLSYGRRPHILLIISGPSTSSTILERKIRWMSPKAPPS 324
             .::.::||...:..:.:    |:.|..:...:..:.|.:..||           .|:...|...
 Worm   144 FDLSDMLAKYLSINRNRMGFLSVEPYAAIEGNKSVNRLYVSPGP-----------HWVYNWAMGI 197

  Fly   325 RI-RQGVPKLLADLIE------NFLPYFVSYAQRVSEKDTIFEFIKDLNKLQVEHSRRGFWDSTV 382
            .| :..|..:|..|::      |...|...:|:.| :.:..|..:.|...|.:::.     :.:.
 Worm   198 SIYKDSVAFMLRRLLKLENRELNETIYDKEFAELV-QLEANFSTLADYRNLALDND-----NMSK 256

  Fly   383 LYNVSSLQDLYPVLNWTLLIPQNWSGPIVVRNSDYLKAL-----------------------EYF 424
            ..|::.|..:.|.::|..:                ||||                       |||
 Worm   257 SRNLTDLVKMIPEIDWIKI----------------LKALARHGTSEEDEEKLLERVTVHGAGEYF 305

  Fly   425 L----------TKYPTRVAHNSL----LLLSALQILPRDYP----------SPEVCTRSTMWALP 465
            .          |:.|.....|.|    |:..||....:|.|          ....|........|
 Worm   306 FGENRELARIATETPKSALANYLVVRQLIDVALYFYDKDQPRQNKFYNHVDQQSFCATQVASFFP 370

  Fly   466 ELSSSLYIAQHSSEDLKDTTKRAEIIFKSLKAHLKR--------APSLKGAALVKLSALKIQ--- 519
            ..|.:::|  .||:...:..|..|.:|..:||..::        ...::...:.||:|:..:
 Worm   371 MPSMNVFI--ESSQFKIENLKVIEEMFVKIKAEYEQIFTENEYLELEIREFLIRKLNAIDGKFGL 433

  Fly   520 SQTWEG------FSNTTDLLKSLQPLNITSECW----FQNILEIYKKNKLEPNDISLNGGSHDAW 574
            .|..||      ...|.:.|.:..|..:..:.|    .|.:..|.....|:|.::.: .|:|.|:
 Worm   434 DQYTEGKPLLEKMYETLNFLDTDSPWQVYMKMWRHWSEQLVEHIVHDTPLDPVNLKM-FGTHAAY 497

  Fly   575 -AYPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEI-------LRSITKS 631
             .||   ..||        :.|..:..|:.:|..|...:|..:|..|..||       .|.:.:|
 Worm   498 QPYP---NHFY--------INLPYLTYPWMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDES 551

  Fly   632 -------------------FDEKAMRCVPHSVNIFSNYSRMDILIHSGGMQISYHSMLSLTGPIK 677
                               ..||.:|      :.:|.|..........|.    |....:.|...
 Worm   552 GRQQQYWFTETNSSNTEYELREKCLR------DQYSAYKEPGYDFFMNGT----HCRYEIAGDHM 606

  Fly   678 GMA---------------RLPGLNLTPTQIFFLVSAQELC-------AESNYL------------ 708
            |:.               |||||.::..|:||...|...|       ...|.|
 Worm   607 GIRTAFRVFEKVKKEDRFRLPGLEMSEEQLFFYNYAFRQCDVYNPNKLPRNMLARQHPTNRYRVN 671

  Fly   709 GIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            |:..|.|||              .|.|.||..|.:|.:..|.:
 Worm   672 GVIQNIPEF--------------AEAFNCPKNSPMNPEMKCKL 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	139/730 (19%)
nep-18	NP_494297.1	M13	47..699	CDD:341056	139/731 (19%)