DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl16 and Ece2

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_647454.2	Gene:	Ece2 / 107522	MGIID:	1101356	Length:	763	Species:	Mus musculus

Alignment Length:	773	Identity:	165/773 - (21%)
Similarity:	281/773 - (36%)	Gaps:	196/773 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 TSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVASSIQARLN 172
            |...|::..|::....|.|.......:.||         ||.|.   |....|..||..|...|:
Mouse    57 TQLELVLAGLILVLAALLLGCLVALWVHRD---------PAHST---CVTEACIRVAGKILESLD 109

  Fly   173 WNKDPCTEFKKFSC--W-RNTPNKNITNLIEMGNSQKSVDSQML-YLFQNKIMNGSFGI---LHN 230
            ....||.:|.:|||  | |..|..|..:.....||....:..:| :|.:|...|.|...   ..:
Mouse   110 RGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTRS 174

  Fly   231 LFESCLQ----QTTNSTVMHRIFDSLGGYLPVGSVGPSSIAPLIAKIYDLGPSPLVDLYHDLSYG 291
            .:.||||    :...:..:..:.|.:||:...|.....|...::..:..             :|.
Mouse   175 FYLSCLQSERIEKLGAKPLRDLIDKIGGWNITGPWDEDSFMDVLKAVAG-------------TYR 226

  Fly   292 RRPHILLIISGPSTS--STILERKIRWMSPKAPPSR----IRQGVPKLLADLIENFLPYFVSYAQ 350
            ..|...:.:|..|.|  |.|::..   .|....|||    .|....|:|.    .:|.|.|....
Mouse   227 ATPFFTVYVSADSKSSNSNIIQVD---QSGLFLPSRDYYLNRTANEKVLT----AYLDYMVELGV 284

  Fly   351 RVSEKDT--------IFEFIKDLNKLQVEHSRRGFWDSTVLY---NVSSLQDLYPVLNWT----- 399
            .:..:.|        :.|....|..:.|...:|.  |...:|   ::|.||.|.|.::|.
Mouse   285 LLGGQPTSTREQMQQVLELEIQLANITVPQDQRR--DEEKIYHKMSISELQALAPAVDWLEFLSF 347

  Fly   400 LLIPQNW--SGPIVVRNSDYLKALEYFLTKYPTRVAHNSLL------LLSAL---------QILP 447
            ||.|...  |.|:||..::||:.:...:.:....:.:|.|:      ..|:|         ::|.
Mouse   348 LLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLE 412

  Fly   448 RDY-------PSPEVCTRSTMWALPELSSSLYI-------AQHSSEDLKDTTKRA------EIIF 492
            ..|       |..:.|..:|..||.....||::       ::..:|.:.:..:.|      ::::
Mouse   413 TLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMINEIRSAFEETLGDLVW 477

  Fly   493 KSLKAHLKRAPSLKGAALVKLSAL-------------KIQSQTWEGFSNTTDLLKSLQPLNITSE 544
            ...|..|        ||..|..|:             |.....::|:             .::.:
Mouse   478 MDEKTRL--------AAKEKADAIYDMIGFPDFILEPKELDDVYDGY-------------EVSED 521

  Fly   545 CWFQNILEIYKKNKLEPNDISLNGGSHDAWAY-PIVSTIFYDTLSHSIVVPLSVILIPYFNAVLP 608
            .:|||:|.:|..:.....|......|.|.|:. |.....:|....:.||.|..::..|::....|
Mouse   522 SFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHP 586

  Fly   609 PYLHYASVGVSIAKEILRSITKSFD------EKAMRCVP----HSVNIFSN--------YSRMDI 655
            ..|::..:||.:..|    :|.:||      :|.....|    .|:..|.|        ||:..:
Mouse   587 KALNFGGIGVVMGHE----LTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQV 647

  Fly   656 --------------LIHSGGMQISYHSMLSLTGPIKGMAR-------LPGLNLTPTQIFFLVSAQ 699
                          :..:||::.:|::       .|...|       ||.:.||..|:||:..||
Mouse   648 NGERLNGLQTLGENIADNGGLKAAYNA-------YKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQ 705

  Fly   700 ELCA----ESNYLGI--DTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            ..|:    ||::.|:  |.::|....:||.| :........|.||.||.:|..:.|.|
Mouse   706 VWCSVRTPESSHEGLVTDPHSPARFRVLGTL-SNSRDFLRHFGCPVGSPMNPGQLCEV 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	147/701 (21%)
Ece2	NP_647454.2	M13	112..761	CDD:189000	147/703 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010