Protein Alignment Nepl16 and kel

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: XP_068070210.1
• Gene: kel / 101882278
• ZFINID: ZDB-GENE-110411-118
• Length: 793
• Species: Danio rerio
• Alignment Length: 716
• Identity: 145/716 - (20%)
• Similarity: 239/716 - (33%)
• Gaps: 233/716 - (32%)

  Fly   150 SAPPECSDPICEAVASSIQARLNWNKDPCTEFKKFSCWRNTPNKN-----------------ITN 197
            ||.|.|..|.|...:......::....||..| .|:|.....:.|                 ...
Zfish   107 SAAPLCLSPACIRASEHFSVAMDPFSRPCDYF-LFACGAGGSSTNRDRQRVKGEVNKHSEVRTRG 170

  Fly   198 LIEM--GNSQKSVDSQMLYLF---QNKIMNGSFGILH----------------NLFESCL----Q 237
            ||||  |....|.....|..|   |..::.....||.                |.|:||:    :
Zfish   171 LIEMRRGTDGWSKSDGQLKTFPDRQTALLTAIKEILEAPDEAVSMGAAEQKAKNFFKSCMNAESR 235

  Fly   238 QTTNSTVMHRIFDSLGGYLPVG-------------SVGPSSIAPLIAKIYDLGPSPLVDLYHDLS 289
            :...|.....:...|||:...|             .:|..|..|.. .:| :||.|    ..:.|
Zfish   236 EKMGSEPFLTLLQQLGGWAVSGVWNQTDFNSTLALLMGQYSTFPFF-NVY-VGPEP----SEEQS 294

  Fly   290 YGRRPHILLIISGPSTSSTILERKIRWMS----PKAPPSRIRQ------------GVPK------ 332
            ...|.:|.  |..|.     .:..|.|.|    .||....:|.            |||.
Zfish   295 ASNRHYIQ--IDEPH-----FQFPIEWNSKTQKAKANTRYLRPFYSACGQYLVLLGVPSDRTTQH 352

  Fly   333 --LLADL-----IENF-LPYFVSYAQRVSEKDTIFEFIKDLNKLQVEHSRRGFWDSTVLY---NV 386
              |...|     :..| |||      |:|:|                          :||   .:
Zfish   353 CGLFVSLSTTLAVATFPLPY------RLSQK--------------------------LLYRRTTI 385

  Fly   387 SSLQDLYPVLNWTLLIPQNWSGPIVVRNSDYLKA--LEYFL----TKYPTRVAH--------NSL 437
            ..||.|.|.::|...:...:. |:::..||.:..  |.|.:    |.:..:|.|        |:.
Zfish   386 QELQTLAPAVDWLACLQATFQ-PLLISKSDIVLVHNLPYIIHMSKTIHLWQVQHELMGTGPLNTY 449

  Fly   438 LLLSALQ-ILP----------RDY----------PSPEVCTRSTMWALPELSSSLYIAQHSSEDL 481
            ::.|.|| ::|          |:|          |....|.:.|......|.|.....:|:.
Zfish   450 MIFSLLQTLIPALDSRFFQIMRNYSIATGDTQEMPHWWRCVQQTERGFDTLLSHAIREKHAQ--- 511

  Fly   482 KDTTKRAEIIFKSLKAHLK----RAPSLKGAALVKLSALKIQSQTWEGFSNTTDLLKSLQPLNIT 542
            |:..:..:.::.|||..|.    |........|.|:::|..:..|.....:.|:|....:.:.:.
Zfish   512 KEAEELIQDVYSSLKKKLTDLSWRDEKESDFILNKINSLNPRISTNTNNLSYTELNHLYEKVILN 576

  Fly   543 SECWFQNILEI-YKKNKLEPNDISLNGGSHDAWAYPIVSTIFYDTLSHSIVVPLSVILIPYFNAV 606
            .|.:|.|.|:| ..:.|.....:||...:......|.:|       .:.|:||:.:.:.|:|::.
Zfish   577 EEDFFSNYLQILLLEQKSRARLLSLGTQTEGLSMTPFIS-------GNDIIVPVGMFVSPFFHSS 634

  Fly   607 LPPYLHYASVGVSIAKEILRSITKSFDEKAMRCVPHSVNIFSNYSRMDILIHSGGMQISYHSMLS 671
            .|..|:|.::|..:||::|..:......||......|:.::|:|                   ||
Zfish   635 YPRALNYGTLGSLMAKDLLHLLLPDIYTKAKNPETESLCVWSHY-------------------LS 680

  Fly   672 LT-GPIKGMARLPGLNLTPTQIFFLVSA--QELCAESNYLGI--------------DTNAPEFDN 719
            :| ||..|.|            |:|.|:  ||:..:.:.|.:              |::.|.|..
Zfish   681 VTKGPGWGDA------------FYLPSSKQQEVWVQYSALQVALDAYKMSFKRYLADSSLPGFSY 733

  Fly   720 I 720
            :
Zfish   734 V 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	139/690 (20%)
kel	XP_068070210.1	GluZincin	133..>654	CDD:472708	117/577 (20%)
		GluZincin	617..>755	CDD:472708	33/149 (22%)