DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and kel

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	XP_005157998.1	Gene:	kel / 101882278	ZFINID:	ZDB-GENE-110411-118	Length:	759	Species:	Danio rerio

Alignment Length:	716	Identity:	145/716 - (20%)
Similarity:	239/716 - (33%)	Gaps:	233/716 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 SAPPECSDPICEAVASSIQARLNWNKDPCTEFKKFSCWRNTPNKN-----------------ITN 197
            ||.|.|..|.|...:......::....||..| .|:|.....:.|                 ...
Zfish    73 SAAPLCLSPACIRASEHFSVAMDPFSRPCDYF-LFACGAGGSSTNRDRQRVKGEVNKHSEVRTRG 136

  Fly   198 LIEM--GNSQKSVDSQMLYLF---QNKIMNGSFGILH----------------NLFESCL----Q 237
            ||||  |....|.....|..|   |..::.....||.                |.|:||:    :
Zfish   137 LIEMRRGTDGWSKSDGQLKTFPDRQTALLTAIKEILEAPDEAVSMGAAEQKAKNFFKSCMNAESR 201

  Fly   238 QTTNSTVMHRIFDSLGGYLPVG-------------SVGPSSIAPLIAKIYDLGPSPLVDLYHDLS 289
            :...|.....:...|||:...|             .:|..|..|.. .:| :||.|    ..:.|
Zfish   202 EKMGSEPFLTLLQQLGGWAVSGVWNQTDFNSTLALLMGQYSTFPFF-NVY-VGPEP----SEEQS 260

  Fly   290 YGRRPHILLIISGPSTSSTILERKIRWMS----PKAPPSRIRQ------------GVPK------ 332
            ...|.:|.  |..|.     .:..|.|.|    .||....:|.            |||.
Zfish   261 ASNRHYIQ--IDEPH-----FQFPIEWNSKTQKAKANTRYLRPFYSACGQYLVLLGVPSDRTTQH 318

  Fly   333 --LLADL-----IENF-LPYFVSYAQRVSEKDTIFEFIKDLNKLQVEHSRRGFWDSTVLY---NV 386
              |...|     :..| |||      |:|:|                          :||   .:
Zfish   319 CGLFVSLSTTLAVATFPLPY------RLSQK--------------------------LLYRRTTI 351

  Fly   387 SSLQDLYPVLNWTLLIPQNWSGPIVVRNSDYLKA--LEYFL----TKYPTRVAH--------NSL 437
            ..||.|.|.::|...:...:. |:::..||.:..  |.|.:    |.:..:|.|        |:.
Zfish   352 QELQTLAPAVDWLACLQATFQ-PLLISKSDIVLVHNLPYIIHMSKTIHLWQVQHELMGTGPLNTY 415

  Fly   438 LLLSALQ-ILP----------RDY----------PSPEVCTRSTMWALPELSSSLYIAQHSSEDL 481
            ::.|.|| ::|          |:|          |....|.:.|......|.|.....:|:.
Zfish   416 MIFSLLQTLIPALDSRFFQIMRNYSIATGDTQEMPHWWRCVQQTERGFDTLLSHAIREKHAQ--- 477

  Fly   482 KDTTKRAEIIFKSLKAHLK----RAPSLKGAALVKLSALKIQSQTWEGFSNTTDLLKSLQPLNIT 542
            |:..:..:.::.|||..|.    |........|.|:::|..:..|.....:.|:|....:.:.:.
Zfish   478 KEAEELIQDVYSSLKKKLTDLSWRDEKESDFILNKINSLNPRISTNTNNLSYTELNHLYEKVILN 542

  Fly   543 SECWFQNILEI-YKKNKLEPNDISLNGGSHDAWAYPIVSTIFYDTLSHSIVVPLSVILIPYFNAV 606
            .|.:|.|.|:| ..:.|.....:||...:......|.:|       .:.|:||:.:.:.|:|::.
Zfish   543 EEDFFSNYLQILLLEQKSRARLLSLGTQTEGLSMTPFIS-------GNDIIVPVGMFVSPFFHSS 600

  Fly   607 LPPYLHYASVGVSIAKEILRSITKSFDEKAMRCVPHSVNIFSNYSRMDILIHSGGMQISYHSMLS 671
            .|..|:|.::|..:||::|..:......||......|:.::|:|                   ||
Zfish   601 YPRALNYGTLGSLMAKDLLHLLLPDIYTKAKNPETESLCVWSHY-------------------LS 646

  Fly   672 LT-GPIKGMARLPGLNLTPTQIFFLVSA--QELCAESNYLGI--------------DTNAPEFDN 719
            :| ||..|.|            |:|.|:  ||:..:.:.|.:              |::.|.|..
Zfish   647 VTKGPGWGDA------------FYLPSSKQQEVWVQYSALQVALDAYKMSFKRYLADSSLPGFSY 699

  Fly   720 I 720
            :
Zfish   700 V 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	139/690 (20%)
kel	XP_005157998.1	GluZincin	99..>620	CDD:301352	117/577 (20%)
kel	XP_005157998.1	GluZincin	583..>721	CDD:301352	33/149 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100