Protein Alignment Smg6 and Smg7

DIOPT Version :10

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: NP_001402669.1
• Gene: Smg7 / 360855
• RGDID: 1310761
• Length: 1212
• Species: Rattus norvegicus
• Alignment Length: 721
• Identity: 146/721 - (20%)
• Similarity: 245/721 - (33%)
• Gaps: 225/721 - (31%)

  Fly   200 LQDAFKQLLLEQLKFVCEHKVDVFFWKLLFYNVRNYLKRQQTDQAH-------THTLLLIEQAIK 257
            |||.::::|:..|::..:.||:...|...|.|....|:.|..::|:       .:..|.:|.|..
  Rat    61 LQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASG 125

  Fly   258 FYRMLYDKLMA------KC-VASSRC-----------------DSALKVVAQRLLICLGDLTRYR 298
            ||..|..:|..      .| |.||:.                 .|:...:.|..|:.|||:.|||
  Rat   126 FYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYR 190

  Fly   299 VNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSL-------LTSN 356
                  ....:|..||:.|.:|||.||.|:||||:::.........::||.||:       ..|.
  Rat   191 ------NQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAAST 249

  Fly   357 SIQSAKESLLDLFDEIRRKYEETEMKQSPMHYAAGSKNQKSKQMRKEVWIYPDGIRRLHRTDDKG 421
            ::|.|....|:..||::.|                             |...|
  Rat   250 NLQKALSKALESRDELKTK-----------------------------WGVSD------------ 273

  Fly   422 NKAKGNKATMAEVNRYEEMPPEEILPRIVSLYLYLLGKLYTGTDVDSLYPLLRKLQIQIGVALRH 486
                                       .:..::...|.:|....::.|.||..||:.|. ..|..
  Rat   274 ---------------------------FIKAFIKFHGHVYLSKSLEKLSPLREKLEEQF-KRLLF 310

  Fly   487 ENLLSRSKLLKIVALNLFVVEHNKPKTSRREMRYHSFN------------FANSFFGLMMKKTNQ 539
            :...:..:|:.:..:|||.:.|.:..::..|.  ||::            ...||.|::.|
  Rat   311 QKAFNSQQLVHVTVINLFQLHHLRDFSNETEQ--HSYSQDEQLCWTQLLALFMSFLGILCK---- 369

  Fly   540 LLAGFVEDSTNVQC-LPEEDFATVNTY-LQFVNVYVRWLSISLDVWEPVRSEEHSFIDCWAELTI 602
                         | |..:...:.|.| |..|.|.:.||.:...|::....:|..:|..|
  Rat   370 -------------CPLQNDSQESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPW----- 416

  Fly   603 LFEYIECLMGKHKLE-----KNEILLDEDVALRGFTPLGRETLSMDYL---------KRGSERLQ 653
               .|..|...|..|     .|...|.|:..|:||..|.....::|:.         |.|.:|..
  Rat   417 ---LISLLNSFHPREDDLSSTNATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRI 478

  Fly   654 FFERVRRIGQF----QEYYVQHQEALQQPLESSFTVEHLNAAMKNALENYDAESCGLAANVSKIQ 714
            ..:|:..||::    |...:|.:..:.:.|   |..|.....:::..|
  Rat   479 RQQRLISIGKWIADNQPRLIQCENEVGKLL---FITEIPELILEDPSE----------------- 523

  Fly   715 CKAVEELLCRSTDSDVSELCK----LKKELEAKARVKQICTSKLEDILKFVDTKIYIEVRPRYL- 774
              |.|.|:.:.|.:..|....    ||..|.........|.|..:.::.|.:     .::||.:
  Rat   524 --AKENLILQETSAIESHASDGSPGLKSVLSTGRSPSTSCDSGEKPVVTFKE-----NIKPREVN 581

  Fly   775 ------LPDTNCFIDC-----------LEDFEKLSTEFKRYTLIIPLTVVKELDGLSKGVKLDSY 822
                  .|......||           .:|..|...|.||.|    |..::|....|..|::.|.
  Rat   582 RDQGRSFPPKEVRRDCSKGVTVTQDDGQKDSSKRRAETKRCT----LGKLQETGKQSVAVQVKSQ 642

  Fly   823 RSSKQT 828
            ...::|
  Rat   643 TELRKT 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	219..298	CDD:463062	26/109 (24%)
		EST1_DNA_bind	310..639	CDD:431239	72/354 (20%)
		PIN_Smg6-like	767..941	CDD:350233	17/80 (21%)
Smg7	NP_001402669.1	EST1	80..192	CDD:463062	28/117 (24%)
		TPR repeat	179..205	CDD:276809	11/31 (35%)
		EST1_DNA_bind	196..455	CDD:431239	72/354 (20%)
		TPR repeat	210..240	CDD:276809	11/29 (38%)