Protein Alignment Smg6 and Smg5

DIOPT Version :10

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: NP_839977.2
• Gene: Smg5 / 229512
• MGIID: 2447364
• Length: 1017
• Species: Mus musculus
• Alignment Length: 960
• Identity: 191/960 - (19%)
• Similarity: 302/960 - (31%)
• Gaps: 383/960 - (39%)

  Fly   165 PHAKNIVH---LYDQLM-VLNQRNLILINWKNFCYIHDQLQDAFKQ---LLLEQLKFVCE----- 217
            |.|| ::|   ||..:: .:::.:|||.|...:       |:.||.   .|..:|:.:|.
Mouse    13 PEAK-VLHTKRLYRAVVEAVHRLDLILCNKAAY-------QEVFKPENVSLRNKLRELCVKLMFL 69

  Fly   218 HKVDV------FFWKLLFYNVRNYLKRQQTDQAHTHTLLLIEQA--------IKFYR--MLY--- 263
            |.||.      ..|:.::|.|...:|   |::.|.|:...:|.|        |.||:  :||
Mouse    70 HPVDYGRKAEELLWRKVYYEVIQLIK---TNKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQS 131

  Fly   264 ----------------DKLMA--KCVASS--RCDSALKVVAQRLLICLGDLTRYRVNHVKATD-Y 307
                            |.||.  |.|::|  ..|.| ::...|.|:.||||:||: |.:...| .
Mouse   132 HYQLELQCCIDWTHVTDPLMGFKKPVSASGKEMDWA-QMACHRCLVYLGDLSRYQ-NELAGVDTE 194

  Fly   308 MEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLTSNSIQSAKESLLDLFDEI 372
            :.|.|:|.:|..:.|..|.|||||..::...:...:|:|.|:|.:.:..|.:.|..:|..|:|:.
Mouse   195 LLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKA 259

  Fly   373 RRKY--------------------------------------------EETEMKQS--------- 384
            .:.|                                            |.|.:.||
Mouse   260 AKMYHQLKKSETRKLSPSKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCL 324

  Fly   385 ---PMHYAAGSKNQKSKQMRKEVWIYPD------------GIRRLHRTDDKGNKA---------- 424
               |.....|..|:..::........||            |:..|.|...|...|
Mouse   325 FYLPSSPNLGLTNEDEEECESGYAFLPDLLIFQMAIICLMGVHSLKRAGSKHYSAAIAFTLALFS 389

  Fly   425 ---------------KGNKATMA------------EVNRYEEMPPEEILPRIV-----------S 451
                           :|.....|            |....||..||.  |.:|           .
Mouse   390 HLINHVNIRLQAELEEGENPVSAFQSDGTDEPESKEALEKEEPEPEP--PTVVPQADEGRKSRKH 452

  Fly   452 LYLYLLGK--------------LYTGTDVDSLYPLL-----------RKLQIQIGVALRHE---- 487
            ..|..|.:              |..|.:.||.:...           :.|:.: |.|...|
Mouse   453 SRLSCLRRRRRHHPPKAGDDSDLSEGFESDSSHDSAQASDGSDSGSDKSLEGR-GTAFDAETDSE 516

  Fly   488 --NLLSRSKLLKI----------------------------------VALNLFVVEHNKPKTSRR 516
              :..|||.|..:                                  :|.||..:.....:|.|
Mouse   517 MNSQESRSDLEDMEDEEGTRSPAQEPPQARSEVPDSLNGPLGPSEASIASNLQAMSTQMFQTKR- 580

  Fly   517 EMRYHSFNFANSFFGLMMKKTNQ---------LLAGFVE----------------DSTNVQCLPE 556
                 .|..|.:|..|:::.|.:         .:.|.::                :|:|..|..|
Mouse   581 -----CFRLAPTFSNLLLQPTTEPNSVASHRPCVNGDMDKPLEPASEDGSESEGSESSNRSCRNE 640

  Fly   557 EDF------ATVNTYLQFVNVYVRWLSISLDVWEPVRSEEHSFIDCWAELTILFEYIE------- 608
            ...      ......|..|.|::.||..:.|:.........|.   |..|::|...:.
Mouse   641 RSLQEKLQALMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSL---WNRLSVLLNLLPASAELQD 702

  Fly   609 -----CLMGKHKLEKNE-------ILLDEDVALRGFTPL-----------GRETLSMDYLKRGSE 650
                 |...:..||..|       :||.||:|||...||           .|..||.  |:....
Mouse   703 SGLALCSEVQGLLEGCELPDLPASLLLPEDMALRNLPPLRAAHRRFNFDADRPLLSA--LEESVV 765

  Fly   651 RL-------QFFERVR--------RIGQFQEYYVQHQEALQQPLESSFTVEHLNAAMKNALENYD 700
            |:       .|..|::        .:|.|.......||:|.|..::.|.:.. ..|.:|.|
Mouse   766 RICCIRSFGHFVARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAE-EEARRNRL---- 825

  Fly   701 AESCGLAANVSKIQCKAVEELLCRSTDSDVSELCKLKKELEAKARVKQICTSKLEDILKFVDTKI 765
                                         :.::.:|:.:||         .|:||..|:  ..|.
Mouse   826 -----------------------------MRDMAQLRLQLE---------VSQLEGSLQ--QPKA 850

  Fly   766 YIEVRPRYLLPDTNCFIDCLEDFEKLSTEFKRYTLIIPLTVVKELDGLSK 815
            ...:.| ||:|||......|....:|:|. .|:.:|||.||:..||.|.|
Mouse   851 QSAMSP-YLIPDTQALCYHLPLIRQLATS-GRFIIIIPRTVIDGLDLLKK 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	219..298	CDD:463062	31/117 (26%)
		EST1_DNA_bind	310..639	CDD:431239	97/570 (17%)
		PIN_Smg6-like	767..941	CDD:350233	19/49 (39%)
Smg5	NP_839977.2	EST1	77..188	CDD:463062	31/115 (27%)
		EST1_DNA_bind	197..>411	CDD:431239	36/213 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	406..562		23/158 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..640		4/42 (10%)
		EST1_DNA_bind	<652..745	CDD:431239	23/95 (24%)
		PIN_Smg5-like	856..1014	CDD:350232	19/45 (42%)