Protein Alignment Smg6 and Smg6

DIOPT Version :10

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: XP_061509760.1
• Gene: Smg6 / 1277412
• VectorBaseID: AGAMI1_008401
• Length: 1576
• Species: Anopheles gambiae
• Alignment Length: 1086
• Identity: 279/1086 - (25%)
• Similarity: 481/1086 - (44%)
• Gaps: 259/1086 - (23%)

  Fly    36 AAATTTKALETENAENAEPVATTANASRPVEILSNASTGGGKPDAQSKQPVLDTSGKMAWEGGIP 100
            :|::|..|.|.......:.:....|.|:|:.:....|....:.||:.
Mosquito   566 SASSTVAAAECGGGRETKLLFDPKNPSQPIVVTRTQSRASKQRDARD------------------ 612

  Fly   101 GILRVTTSVAGDVNRNGQGQGKNKSGNSARRRGRKDKEHATQSPVTRTRLTTEHPDWFEPLLGLP 165
                   |:..|..|:|   |:::....                          |.|:.|  ...
Mosquito   613 -------SLRRDEGRDG---GRHQLAGG--------------------------PAWYNP--DGQ 639

  Fly   166 HAK---------NIVHLYDQLMVLNQRNLILINWKNFCYIHDQLQDAFKQLLLEQLKFVCEHKVD 221
            .||         .:|....||..|.:...:...|..:..|...|||..:..|:.:::|..:..::
Mosquito   640 QAKLLRQKELIYKVVEADAQLQELMESGNLYAEWARYEQIRRGLQDLLETFLVREMRFAQDVNLE 704

  Fly   222 VFFWKLLFYNVRNYLKRQ----QTDQ----AHTHTLLLIEQAIKFYRMLYDKL-------MAKCV 271
            ..|||:|||.:...|::|    |.:|    .....|.::|....::..|...|       :.:.:
Mosquito   705 HHFWKMLFYGIIEQLRKQLSEAQDEQWKQYLQERALEVVESGTAYFEQLLTLLEREHRFSLEQFI 769

  Fly   272 ASSRCDS------ALKVV-AQRLLICLGDLTRYRVNHVKATDYMEAARYYQRAQELVPGNGAPFN 329
            .::...|      ||.:| :|::.:.||||.|||.......::.:|.::|.:||:::|.||.|:|
Mosquito   770 GANAATSTKGLRYALALVSSQKIFLFLGDLARYREQITGGHNFRKAKQWYVKAQQILPKNGRPYN 834

  Fly   330 QLAVISIYHHKRFDAVYYYVRSLLTSNSIQSAKESLLDLFDEIRRKYEETEMK-QSPMHYAAGSK 393
            |||::|:|..::.||||:|:|||::||..:||:|||:|||:|.::|:|..:.| :..:......|
Mosquito   835 QLALLSVYAKRKIDAVYFYMRSLMSSNPFESARESLMDLFNETKKKFENNQRKREDKLRARRKEK 899

  Fly   394 NQK-SKQMRKEVWIYPDGIRRLHRTDDKGNKAKGNKATMAEVNRYEEMPPEEILPRIVSLYLYLL 457
            .|: ...:|:|:||:|:|..|:|||......|.|:.:..::....:.:...|:..|.:..:|::|
Mosquito   900 EQRFDGNLRREIWIHPEGGSRVHRTGPLYPIAAGHSSDTSDEEELQTLGTIELNKRFIISFLHVL 964

  Fly   458 GKLYTGTDVDSL----YPLLRKLQIQIGVALRHENLLSRSKLLKIVALNLFVVEHNKPK------ 512
            |||.|.|.::|.    ..:||:.::.:.|.   ...::..:||::::||:|.:|..|.|
Mosquito   965 GKLITKTGMESFTQCAQQMLREFRVLVQVT---PIAVTSYRLLQLMSLNMFAIEMTKLKDTSTTG 1026

  Fly   513 -TSRREMRYHSFNFANSFFGLMMKKTNQLL-------AGFVEDSTNVQ---------CLPEEDFA 560
             .:|.|::..:.:.....||:::::..:|:       .|..:|..|..         .|||:
Mosquito  1027 QETRSELQECALSSGLLMFGILLERFIRLIQDALDASEGSAKDPDNGDYGASETPKLILPED--- 1088

  Fly   561 TVNTYLQFVNVYVRWLSISLDVWEPV---------RSEEHSFIDCWAELTILFEYIECLMGKHKL 616
             ....|..:.|:..|:..:.|.|.|.         :|..|   |.|:||.:|...::.|.....:
Mosquito  1089 -AKVILPAIKVWCDWMMSNTDTWNPPPCCADYKIGKSNAH---DPWSELAVLMNILKRLDTNRSI 1149

  Fly   617 ---EKNE-----ILLDEDVALRGFTPL------------------GRETLSMD-YLKRGSERL-- 652
               |:||     :.|.||:.|.|||||                  .:..|.:. .|..|::||
Mosquito  1150 LSVEQNEAGYENVRLPEDITLAGFTPLMYYDPEPIFVHPECDMEEAQNVLRIQKLLYFGTDRLCH 1214

  Fly   653 ---------QFFERVRRIGQFQEY-YVQHQEA----LQQPLESSFTVEHLNAAMKNALENYDAES 703
                     |...|....|..|.| .||::.|    :...|||....|.|..|           :
Mosquito  1215 CEPPVLRREQGAPRGMAEGGAQFYSVVQNRTARLSDMDILLESYSDDEELEPA-----------T 1268

  Fly   704 CGLAANVSKIQCKAVEE------------------LLCRSTDSDVS---------ELCKLKKELE 741
            .|:.|:...:. |:||:                  :|..|:.|.:|         :|.:.|.|||
Mosquito  1269 DGVRASGGDLP-KSVEQHQGSGAVGDPSTPSADSGVLSGSSSSSISNGPSSLETRKLLRRKDELE 1332

  Fly   742 AKARVKQICTSKLEDILKFVDTKIYIEVRPRYLLPDTNCFIDCLEDFEKLSTEFKRYTLIIPLTV 806
            .|.|:::..:.:|:|||......:.|||.||.|:.|||||:|.|...|.::.....|.|::|:.|
Mosquito  1333 RKQRMQEKHSQRLQDILSQSTIAVSIEVHPRLLVTDTNCFVDYLGAIELIAKAHPLYQLMVPIIV 1397

  Fly   807 VKELDGLSKGVKLDSYR-------------------------------------SSKQTQRIH-- 832
            :.||:|||||::..|.:                                     ||.....:|
Mosquito  1398 INELEGLSKGLRNQSPKQQAASTAAVAEILVPVQKQLALPTAPATVVSIAPANSSSTSAAGLHQQ 1462

  Fly   833 HFDEVSSRAKKSLEFIKSAKGNVKCATTKGSFVNASVFALVEE--EYLSNDDKILATAMAVSKTA 895
            |..:|:..:||:|:||||....:||.|||||.:..|.|.:.::  :..||||:||.||:.:.:.
Mosquito  1463 HAAKVADASKKALQFIKSRNPALKCVTTKGSILKTSTFTVEDDVGDLKSNDDRILETALNLCRN- 1526

  Fly   896 KTEQCTDGKCFIQTELVLITTDRNLRVKALSRNLAVSALDEFLQWA 941
            ..|:...|..::..::||:||||||||||:|.:|.|..:.:|::||
Mosquito  1527 HIEETRAGTRYLTMDVVLLTTDRNLRVKAISNDLPVREIPDFIKWA 1572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	219..298	CDD:463062	24/100 (24%)
		EST1_DNA_bind	310..639	CDD:431239	108/392 (28%)
		PIN_Smg6-like	767..941	CDD:350233	73/214 (34%)
Smg6	XP_061509760.1	None