Protein Alignment Smg6 and smg6

DIOPT Version :10

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: XP_012812911.1
• Gene: smg6 / 100380118
• XenbaseID: XB-GENE-5817473
• Length: 1384
• Species: Xenopus tropicalis
• Alignment Length: 1136
• Identity: 272/1136 - (23%)
• Similarity: 471/1136 - (41%)
• Gaps: 282/1136 - (24%)

  Fly    23 LQNKIAASCSH-------AAAAATTTKALETENAENAEPVATTANASRPVEILSNASTGG--GKP 78
            |.|:......|       .|.:::..:::..:|.|....|.::..|||..|  :|...||  .:|
 Frog   313 LSNRYREKKKHLPGDKGLVAKSSSERRSVSRDNTEKNSHVESSLRASRNEE--NNRRRGGRAARP 375

  Fly    79 DAQ--SKQPVLDTSGKMAWEG-GI---PGILRVTTSVAGDVNRNGQGQGKNKSGNSA-RRRGRK- 135
            .:.  .|:.|.:.|.:...:| ||   |....::::.|.:.|.|........:||.. |.|||.
 Frog   376 HSSDTGKEQVREKSAEPTGKGRGILILPANTDLSSNSAVEANHNSTKPLFIPNGNKGLRGRGRGG 440

  Fly   136 ------DKEHATQSPVTRTRLTTEH----------------------PDWFE------------- 159
                  |..:..|.|..:.:.:..|                      |.:::
 Frog   441 GNRRLWDPNNPDQKPALKNQSSQLHFLDTDDETSPTSQGEAYQSLNQPSYYKFQNSDNPYYYPRS 505

  Fly   160 --------------------------------------PLLGLP--------HAKNIVH--LYDQ 176
                                                  |..|.|        ..:.:.|  |...
 Frog   506 PFTYGGFSMPYSVGTSNGMYPGAYYPGFPPQPGQFASGPYSGSPLTPEEMEHQVRTLQHQELNRM 570

  Fly   177 LMVLNQRNLILIN-----------WKNFCYIHDQLQDAFKQLLLEQLKFVCEHKVDVFFWKLLFY 230
            |.:.:.:.|.|.|           ......:..:|...:::.||..::|..:|.||...||.:||
 Frog   571 LRMADNQELQLSNLLSRDGMSTEGLNRMASLRSELLQVYERCLLSDIEFSDQHNVDQLLWKNVFY 635

  Fly   231 NV----RNYLKRQQTDQAHTHTLLL--IEQAIKFYRMLYDKLM------------AKCVASSRCD 277
            .|    |::||...:|.......||  :::...|:..|..||.            ...:.|....
 Frog   636 QVIEKFRHFLKETSSDSEEIRRKLLQVLDEGTAFFDSLLQKLQVTYQFKLEEYMDGMAIRSKPLR 700

  Fly   278 SALK---VVAQRLLICLGDLTRYRVNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHH 339
            ..:|   :.|||.:||.||:.|||......::|.:|..:|.:||::.|.||.|:||||:::||..
 Frog   701 KMVKFALISAQRCMICQGDIARYREQAADTSNYGKARSWYLKAQQIAPKNGRPYNQLALLAIYTR 765

  Fly   340 KRFDAVYYYVRSLLTSNSIQSAKESLLDLFDEIRRKYEETEMKQSPMHYAAGSKNQKSKQMRKEV 404
            ::.||||||:|||..||.|.:|||||:.||:|.:||.::.|.||..   ..|..:......|.|:
 Frog   766 RKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKADQLEQKQQK---ERGVSHTSDDTTRSEI 827

  Fly   405 WIYPDGIRRLHRTDDKGNKAKGNKATMAEVNRYEEMPPEEILPRIVSLYLYLLGKLYTGTDVDSL 469
            ||:|  |||            |.::  .|.:..:.:.|.::..|.:..:|:..|||:|...:::
 Frog   828 WIHP--IRR------------GRES--GECDALDALSPSDLNKRFLLSFLHAQGKLFTRIGMET- 875

  Fly   470 YPLL-RKLQIQIGVALRHE-NLLSRSKLLKIVALNLFVVEHNKPKTSRRE-----MRYHSFNFAN 527
            :||: :|:..:....|:|. :.:..:::|:::|:|:|.|.:::.|..:.|     ::..:.:...
 Frog   876 FPLVAKKVLKEFQALLQHSPSPIGSTRMLQLMAINMFAVNNSQSKAGQAEGSCSVVQEQATSLGL 940

  Fly   528 SFFGLMMKKTNQLLAGFVEDSTNVQ----CLP----------EEDFATVNTY-------LQFVNV 571
            |.|.|::.:..|||        |||    | |          |:|...|:::       |..|.|
 Frog   941 SMFSLLVCRCIQLL--------NVQKKAHC-PRGKGQSMEEEEDDDIKVSSFIPDLKELLPSVKV 996

  Fly   572 YVRWLSISLDVWEP----VRSEEHSFIDCWAELTILFEYIECLMGKHKLE----------KNEIL 622
            :..|:....|.|.|    :...:...:|.|.   :|.|:...|...::.|          .:.::
 Frog   997 WSDWMLGHPDTWNPPPNSLADLKEPALDVWG---VLAEFCNALTSVNQSEVPLYKDPDDDLSLLI 1058

  Fly   623 LDEDVALRGFTPLGRETLSMDYLKRGSERL--QFFERVRRIGQFQEYYVQHQEAL---------- 675
            |:||..|.||.||........|:::.|:::  ...:||..:..|.|.....:|.|
 Frog  1059 LEEDRLLSGFVPLLAAPQEPCYVEKTSDKIIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVS 1123

  Fly   676 QQPLESSFTVEHLNAAMKNALENYD------------AESCGLAANVSKIQCKAVEELLCRSTDS 728
            ..|:..:...| ..:...|.:|:.|            .||.|...:..:::.|..|  |.|..:.
 Frog  1124 VAPVPDTIGKE-TGSPEGNQMEDQDDVVIEEYEEDSEPESSGAEHDFRELRAKKQE--LARKVEE 1185

  Fly   729 DVSELCKLKKELEAKARVKQICTSKLEDILKFVDTKIYIEVRPRYLLPDTNCFIDCLEDFEKLST 793
            ......|::..|:.|.|:.|                  :|:.|.:|:||||.||:.|...|.| .
 Frog  1186 QKRRQQKIQAVLDGKTRLLQ------------------LEICPLFLVPDTNGFINHLPGLEHL-L 1231

  Fly   794 EFKRYTLIIPLTVVKELDGLSKGVKLDSYRSSKQTQRIHHFDEVSSRAKKSLEFI----KSAKGN 854
            ..:.|.|:|||.|:.|||||:||.:.|.       :...|...:..:|:|:::|:    ::....
 Frog  1232 SCQIYILVIPLIVIHELDGLAKGQEFDQ-------RNADHARALQEKARKAIQFLEQGFEARDPY 1289

  Fly   855 VKCATTKGSFVNASVFALVEEEYLS-----NDDKILATAMAVSKTAKTE---QCTDGKCFIQTEL 911
            ::..|::|:.:::..|   ..|.:|     |||.||...:...|....|   ...|....::.|:
 Frog  1290 LRALTSRGNELDSIAF---RSEDISGQKGNNDDLILCCCLHYCKDKAKEFMHSRKDEPIRLRREV 1351

  Fly   912 VLITTDRNLRVKALSRNLAVSALDEFLQWAK 942
            ||:|.|||||||||:|::.|..:..||:|||
 Frog  1352 VLLTDDRNLRVKALTRHVPVRDIPAFLKWAK 1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	219..298	CDD:463062	27/99 (27%)
		EST1_DNA_bind	310..639	CDD:431239	104/370 (28%)
		PIN_Smg6-like	767..941	CDD:350233	60/185 (32%)
smg6	XP_012812911.1	Glutenin_hmw	<453..>580	CDD:367362	10/126 (8%)
		EST1	624..726	CDD:463062	29/101 (29%)
		EST1_DNA_bind	736..1071	CDD:431239	102/366 (28%)
		TPR repeat	750..778	CDD:276809	16/27 (59%)
		PIN_Smg6-like	1206..1381	CDD:350233	60/185 (32%)