DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmnat and NMA2

DIOPT Version :9

Sequence 1:	NP_651315.2	Gene:	Nmnat / 42987	FlyBaseID:	FBgn0039254	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_011524.1	Gene:	NMA2 / 852893	SGDID:	S000003242	Length:	395	Species:	Saccharomyces cerevisiae

Alignment Length:	263	Identity:	100/263 - (38%)
Similarity:	146/263 - (55%)	Gaps:	27/263 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TKSL-----LPRIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLA 98
            ||.|     ||.| .:|||.|||.|.:||||||:|.|....|....||||..||..|:|.|:|||
Yeast   149 TKKLQDPEKLPLI-IVACGSFSPITYLHLRMFEMALDDINEQTRFEVVGGYFSPVSDNYQKRGLA 212

  Fly    99 SALDRCAMVKLATQ-SSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHINSGGGGGDDGENTHL 162
            .|..|..|.:||.: :|:|:.:..||..|:.:.||..||.|..:.||  |..||....|||
Yeast   213 PAYHRVRMCELACERTSSWLMVDAWESLQSSYTRTAKVLDHFNHEIN--IKRGGIMTVDGE---- 271

  Fly   163 PGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFD 227
                       :..|.:.||.|.||:||...|.:||::|:..|:.|:|.:::.|.||:...|:..
Yeast   272 -----------KMGVKIMLLAGGDLIESMGEPHVWADSDLHHILGNYGCLIVERTGSDVRSFLLS 325

  Fly   228 SDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNFKS---KYI 289
            .||:.:::.||.:|...:.|::|||.:|..:.||.||:|||.:.|:.||:...|:..:|   |.:
Yeast   326 HDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRGMSVQYLLPNSVIRYIQEYNLYINQSEPVKQV 390

  Fly   290 TDA 292
            .|:
Yeast   391 LDS 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmnat	NP_651315.2	NMNAT_Eukarya	46..282	CDD:185681	91/236 (39%)
NMA2	NP_011524.1	NMNAT_Eukarya	160..380	CDD:185681	91/237 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345825
Domainoid	1	1.000	143	1.000	Domainoid score	I998
eggNOG	1	0.900	-	-		E1_COG1057
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I1045
Isobase	1	0.950	-	0	Normalized mean entropy	S1288
OMA	1	1.010	-	-		QHG54406
OrthoFinder	1	1.000	-	-		FOG0000967
OrthoInspector	1	1.000	-	-		otm46615
orthoMCL	1	0.900	-	-		OOG6_100907
Panther	1	1.100	-	-	O	PTHR12039
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R815
SonicParanoid	1	1.000	-	-		X704
TreeFam	1	0.960	-	-
	15	14.740