Protein Alignment: Nmnat and NMNAT1

• Sequence 1: NP_651315.2
• Gene: Nmnat
• FlyBaseID: FBgn0039254
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_001284707.1
• Gene: NMNAT1
• HGNCID: 17877
• Length: 279
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 116/258 (45%)
• Similarity: 160/258 (62%)
• Gaps: 21/258 (8%)

  Fly    46 IAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLA 110
            :..:|||.|:|.|.||||:||:|||:....|.:.||.|||||..|:|.||||..|..|..|.:||
Human     9 VVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGLIPAYHRVIMAELA 73

  Fly   111 TQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHINSGGGGGDDGENT---HLPG----WL-- 166
            |::|.|:.:..||..|.:|..|..||:|||..:.      ....|..:|:   ..||    |.
Human    74 TKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLE------ASDCDHQQNSPTLERPGRKRKWTET 132

  Fly   167 -----PRGLHDSRDPV-HLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFI 225
                 .:.|......| .:|||||||||||||||.||...||..||||:||:.:||||::..|||
Human   133 QDSSQKKSLEPKTKAVPKVKLLCGADLLESFAVPNLWKSEDITQIVANYGLICVTRAGNDAQKFI 197

  Fly   226 FDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNFKSK 287
            ::||:|.|::|||.::..|:.|::|||.|||.|.||||::||:.|||.|||::..|::.:|:
Human   198 YESDVLWKHRSNIHVVNEWIANDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHNLYSSESE 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmnat	NP_651315.2	NMNAT_Eukarya	46..282	CDD:185681	115/251 (46%)
NMNAT1	NP_001284707.1	NMNAT_Eukarya	9..254	CDD:185681	115/251 (46%)
		Substrate binding. {ECO:0000269|PubMed:11959140}	55..57		1/2 (50%)
		Substrate binding. {ECO:0000269|PubMed:11788603, ECO:0000269|PubMed:11959140}	92..95		1/3 (33%)
		Nuclear localization signal. {ECO:0000255}	123..129		2/6 (33%)
		Substrate binding. {ECO:0000269|PubMed:11788603, ECO:0000269|PubMed:11959140}	168..169		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C18042258
eggNOG	1	0.900				E1_COG1057
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3523
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D1308027at2759
OrthoFinder	1	1.000				FOG0001264
OrthoInspector	1	1.000				T609642
orthoMCL	1	0.900				OOG5_128044
Panther	1	1.100			O	PTHR12039
Phylome	1	0.910		0.600	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R815
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	12	11.790