Protein Alignment Nmnat and NMNAT3

DIOPT Version :10

• Sequence 1: NP_651315.2
• Gene: Nmnat / 42987
• FlyBaseID: FBgn0039254
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_001307439.1
• Gene: NMNAT3 / 349565
• HGNCID: 20989
• Length: 346
• Species: Homo sapiens
• Alignment Length: 340
• Identity: 115/340 - (33%)
• Similarity: 156/340 - (45%)
• Gaps: 111/340 - (32%)

  Fly    40 KSLLPRIAFIACGCFSPPTPMHLRMFEIAKDHF-------------------------------- 72
            ||.:| :..:|||.|:|.|.|||||||:|:||.
Human     2 KSRIP-VVLLACGSFNPITNMHLRMFEVARDHLHQTEYEEKDHEVALVFPGPQSISIKDISFHLQ 65

  Fly    73 --------------------------------------------------------------EMQ 75
                                                                          .:|
Human    66 KRIQNNVSSKNDDPDKSSFKRKRTEEQAFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQ 130

  Fly    76 GTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQ 140
            |.::|:.|||||.:|:||||.||::..|.||.:||.|:|:|||:..||..|.|||.|..||:||.
Human   131 GMYQVIQGIISPVNDTYGKKDLAASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHH 195

  Fly   141 NYINNHINSGG--GGGDDGENT-HLPGWLPRGLHDSRDPVHLKLLCGADLLESFAVPGLWAEADI 202
            :.:   :.|..  .|.|.|:.. ..|..:|          .||||||||:|::|..|.||.:|.|
Human   196 SKL---LRSPPQMEGPDHGKALFSTPAAVP----------ELKLLCGADVLKTFQTPNLWKDAHI 247

  Fly   203 EDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYL 267
            ::||...|||.:.|.|.:|..:|.:|.||..:|.||.|....|.||:|:|.|||.||:|||||||
Human   248 QEIVEKFGLVCVGRVGHDPKGYIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYL 312

  Fly   268 LDDLVLEYIKRQRLF 282
            :.|.|:.|||...|:
Human   313 IPDAVITYIKDHGLY 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmnat	NP_651315.2	NMNAT_Eukarya	46..282	CDD:185681	111/332 (33%)
NMNAT3	NP_001307439.1	NMNAT_Eukarya	7..327	CDD:185681	111/332 (33%)
		DTW	<39..>136	CDD:470119	2/96 (2%)