DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmnat and Nmnat1

DIOPT Version :9

Sequence 1:	NP_651315.2	Gene:	Nmnat / 42987	FlyBaseID:	FBgn0039254	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_006239491.1	Gene:	Nmnat1 / 298653	RGDID:	1310996	Length:	316	Species:	Rattus norvegicus

Alignment Length:	299	Identity:	125/299 - (41%)
Similarity:	175/299 - (58%)	Gaps:	47/299 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RRSKSKKM--------SAFIEETKSLLP-------RIAFIACGCFSPPTPMHLRMFEIAKDHFEM 74
            |||.|:.:        ...:::...|||       .:..:|||.|:|.|.||||:||:|||:...
  Rat     4 RRSSSEMLDDNNIGIRGLHLDQQLQLLPMDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYLNA 68

  Fly    75 QGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHH 139
            .|.::|:.|||||..|:|.||||..|..|..|.:|||::|:|:.:..||..|.:|:.|..||:||
  Rat    69 TGEYKVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRHH 133

  Fly   140 QNYINNHINSGGGGGDDGENTH--------LPG----WLPRGLHDS----RDP-----VHLKLLC 183
            |..:..           |..:|        .||    |..:....|    ::|     ..:||||
  Rat   134 QEKLAT-----------GSRSHPQSSPVLERPGRKRKWADQKQDSSPQKPQEPKPTGVPRVKLLC 187

  Fly   184 GADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNE 248
            ||||||||:||.||...||..||||.||:.:|||||:..|||::||:|.::||||.|:|.|:.|:
  Rat   188 GADLLESFSVPNLWKMEDITQIVANFGLICVTRAGSDAQKFIYESDVLWRHQSNIHLVTEWITND 252

  Fly   249 VSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNFKSK 287
            :|||.|||.|.||||::||:.|||.|||:...|:|.:|:
  Rat   253 ISSTKIRRALRRGQSIRYLVPDLVQEYIEEHDLYNSESE 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmnat	NP_651315.2	NMNAT_Eukarya	46..282	CDD:185681	115/256 (45%)
Nmnat1	XP_006239491.1	NMNAT_Eukarya	40..286	CDD:185681	115/256 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E1_COG1057
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3435
OMA	1	1.010	-	-		QHG54406
OrthoDB	1	1.010	-	-		D1308027at2759
OrthoFinder	1	1.000	-	-		FOG0000967
OrthoInspector	1	1.000	-	-		otm44803
orthoMCL	1	0.900	-	-		OOG6_100907
Panther	1	1.100	-	-	LDO	PTHR12039
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X704
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840