Protein Alignment: Nmnat and NMNAT2

• Sequence 1: NP_651315.2
• Gene: Nmnat
• FlyBaseID: FBgn0039254
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_055854.1
• Gene: NMNAT2
• HGNCID: 16789
• Length: 307
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 106/311 (34%)
• Similarity: 158/311 (51%)
• Gaps: 74/311 (24%)

  Fly    37 EETKSLLPRIAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASAL 101
            |.||:   .:..:|||.|:|.|..|::|||.|:|:....|...|:|||:||.||||||:||.|:.
Human     3 ETTKT---HVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSR 64

  Fly   102 DRCAMVKLATQSSNWIRLSDWEVHQNQWMRTQAVLQHHQN------------------------- 141
            .|..|.:||.|:|:|||:..||.:|:.|..|.:||:||::
Human    65 HRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQP 129

  Fly   142 --------YINNHINSG-------GGGGDD-----------------GENTHLPGWLPRGLHDSR 174
                    |.|:::.:.       |..|:.                 .||.:| |.:.|     .
Human   130 QNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANL-GTVMR-----Y 188

  Fly   175 DPVHLK--LLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSN 237
            :.:.|:  ||||:||||||.:||||.|||:|.||.:.|:||:.|..::..:.:..|.||.||::|
Human   189 EEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNN 253

  Fly   238 ITLI---TNWVPNEVSSTLIRRLL--GRGQSVKYLLDDLVLEYIKRQRLF 282
            |.::   .|...:.||||..|..|  |.|..|.| |...|::||.:.:|:
Human   254 IMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDY-LSQPVIDYILKSQLY 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmnat	NP_651315.2	NMNAT_Eukarya	46..282	CDD:185681	103/300 (34%)
NMNAT2	NP_055854.1	NMNAT_Eukarya	9..302	CDD:185681	103/300 (34%)
		Substrate binding. {ECO:0000250|UniProtKB:Q96T66}	55..57		2/2 (100%)
		Substrate binding. {ECO:0000250|UniProtKB:Q96T66}	92..95		1/3 (33%)
		Substrate binding. {ECO:0000250|UniProtKB:Q96T66}	212..213		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG1057
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D1308027at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			LDO	PTHR12039
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R815
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	6	6.000