DRSC/TRiP Functional Genomics Resources

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Protein Alignment DZIP1 and Dzip1

DIOPT Version :10

Sequence 1:NP_651263.1 Gene:DZIP1 / 42921 FlyBaseID:FBgn0039201 Length:737 Species:Drosophila melanogaster
Sequence 2:NP_080219.2 Gene:Dzip1 / 66573 MGIID:1914311 Length:852 Species:Mus musculus


Alignment Length:823 Identity:161/823 - (19%)
Similarity:275/823 - (33%) Gaps:253/823 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 GPL------------DWRLMGSYETERI--------LREQNF-----ELVDKALTHLSEAPLGTV 63
            |||            |||.:.:.:.:::        |:|...     :|.|:...|....     
Mouse    38 GPLPFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSG----- 97

  Fly    64 LETHILDSGIAKYFVMSQYAIQYLMCCRTYLDECVTDLKEAHTTAQEEIATLRKSLSESNNEVVQ 128
                 :|..:.|...::|..|:|||..:.:|...:..::|          .||.||.:.......
Mouse    98 -----VDPVLLKLIRLAQLTIEYLMHSQEFLTSQLNLVEE----------RLRLSLLDYEQSKQL 147

  Fly   129 LHKRITQIEAIRE--------------------VVYPCHLCTKNFISNEALNVHIGRKHRVASPP 173
            |.|:..:|:.::|                    ..|.||.|.|.|::...|..||.|:|      
Mouse   148 LTKQAGEIKLLKEECKRRKKMLSTQQLMIEAKASYYQCHFCDKAFMNQAFLQSHIQRRH------ 206

  Fly   174 SLTSATGKEKDRDKATDVHL-----INTIKMELEIKQLKERLNAAERNIKERSTGSKRVSPRQEQ 233
                          ..|.||     ..|.:::.||..|||:|......::.          .|..
Mouse   207 --------------TEDSHLEYNTKAQTDRLQKEIDMLKEQLQLTRSQLES----------AQHS 247

  Fly   234 RHVGIQSNLAEPKEKDEDSGEARQSEASERKEQLTGLAERLSNFEEWQTQLKQSNEQFIQDINKR 298
            ..|....:....|.|:||..:.......|.||:|....|::..             .|:::. |.
Mouse   248 HAVRFSKDYEMQKSKEEDFLKLFDRWKEEEKEKLLEEMEKVKG-------------MFMREF-KE 298

  Fly   299 LEGLSHALE-QSKQASASTPPLEDRVAT------------PCLEDLERILTEKVAEIGKVSAHRL 350
            |...:.||| |..:...|...::..:.|            ||.:|.:.:|     ::....|.:.
Mouse   299 LTSKNSALEYQLLEIQKSNIQIKSNIGTLRDVTELREDHLPCPQDFQNML-----QLLDSQASKW 358

  Fly   351 EEVVYHLEEGYKEKLGALERELKQLSVQKVQPEPVQTVPVASKIPKPVVRKEETNIDRIRKQVES 415
            .:....|.|.:.::.|.|      ||                            :|:::|    |
Mouse   359 TDRFQVLNEEHSKEKGQL------LS----------------------------HIEKLR----S 385

  Fly   416 EFLKQKHDDDTY---SIEEAPRKGSEKPFPQLVTQVQVVEK--EQPSAGSSDSNPT----YTKSP 471
            ..:|....|:.:   .:||..:|..|:. ..:::|.|.:.:  .:|.:..|:...|    .|..|
Mouse   386 SMMKDLSADNVFYKRRVEELGQKLQEQN-ELIISQKQQIREFASKPYSSISELKGTPLTRQTLEP 449

  Fly   472 REPAPNKQETKEATDVSDSLSQ-----------------EETENEEERSLTEEEGTDVPTSGSEA 519
            :..||....|..||...|..|.                 ||..:|||:....|:..:..||..:.
Mouse   450 KSAAPTTPMTASATQNLDGASSLTMVHEQVFSSHILEPIEELSSEEEKGRENEQKLNKKTSLRKP 514

  Fly   520 AREDPTPKTIKPSGRIIKSPQKPLTRKDARKMVNRKLMSHGFDMKSKGISHNSLKRVNSELTEHR 584
            :...|:|:.:               |.:..:.:..||.|.|.....:||....|.|....:...|
Mouse   515 SSTSPSPQEL---------------RTNLERELGNKLRSFGIGANIQGIPCEILNRSLKAMQVAR 564

  Fly   585 NKLKLQHPHFYATRNRIRKFVEKLCSAKFSERAEMLL-KHKSPL----------KPMEVPGKGIP 638
            :.|..|.|..    .:||:.:|.....|..|:..:.. :|..|.          |..::|.|..|
Mouse   565 HDLAKQMPDI----QQIRESLEHQLICKMEEKVSLSSDRHHVPSMTTFPPEEVPKATQLPHKSRP 625

  Fly   639 ----RSAISEKSEEDIASSQGEE--------QTDEQTDSSEQQTRSPSPQRLVSRDFKARLEEIL 691
                |:..::|..........:|        .|.....|||::   |..:.|:    .|.|....
Mouse   626 LVRQRTVFTDKVSVPKLKKNTKESHFLRRFPSTKTPPFSSEEE---PDEEDLL----HAYLSPDS 683

  Fly   692 VKPAATIRGASKSSLSSRPVPLPRKRVMFNTT-EDGKSFNDSD 733
            :..|||  ...|||:|.    ..:..|..:|. .:|...:|||
Mouse   684 LATAAT--QPPKSSMSH----FGKSAVKSDTDWTEGSEMDDSD 720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DZIP1NP_651263.1 Dzip-like_N 16..133 CDD:433498 26/133 (20%)
SMC_N 182..>457 CDD:481474 52/297 (18%)
Dzip1NP_080219.2 Mediates interaction with GLI3 and localization to the cilium basal body. /evidence=ECO:0000269|PubMed:23955340 1..351 73/381 (19%)
Mediates interaction with PCM1. /evidence=ECO:0000269|PubMed:27979967 1..188 31/169 (18%)
Dzip-like_N 43..163 CDD:433498 25/139 (18%)
Required for interaction with DAZ1. /evidence=ECO:0000250|UniProtKB:Q86YF9 139..262 28/152 (18%)
C2H2 Zn finger 183..207 CDD:275369 11/43 (26%)
zf-C2H2 183..206 CDD:395048 10/22 (45%)
GumC <209..>429 CDD:442439 52/287 (18%)
Mediates interaction with GDI2 and RAB8A. /evidence=ECO:0000305|PubMed:25860027 430..600 40/188 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 434..463 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..524 10/34 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..623 4/25 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 648..672 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..726 13/42 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 772..837
Blue background indicates that the domain is not in the aligned region.

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