Protein Alignment DZIP1 and DZIP1

DIOPT Version :10

• Sequence 1: NP_651263.1
• Gene: DZIP1 / 42921
• FlyBaseID: FBgn0039201
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: XP_006719979.1
• Gene: DZIP1 / 22873
• HGNCID: 20908
• Length: 932
• Species: Homo sapiens
• Alignment Length: 805
• Identity: 170/805 - (21%)
• Similarity: 290/805 - (36%)
• Gaps: 211/805 - (26%)

  Fly    24 GPL------------DWRLMGSYETERI--------LREQNF-----ELVDKALTHLSEAPLGTV 63
            |||            |||.:.:.:.:::        |:|...     :|.|:...|....
Human    99 GPLPFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSG----- 158

  Fly    64 LETHILDSGIAKYFVMSQYAIQYLMCCRTYLDECVTDLKE----AHTTAQEEIATLRKSLSE--S 122
                 :|..:.|...::|:.|:||:..:.:|...:..|:|    :|...::....|.|...|  :
Human   159 -----VDPVLLKLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKT 218

  Fly   123 NNEVVQLHKRI--TQ---IEAIREVVYPCHLCTKNFISNEALNVHIGRKHRVASPPSLTSATGKE 182
            ..|..:..|::  ||   ||| :...|.||.|.|.|::...|..||.|:|         :.....
Human   219 LKEECKRRKKMISTQQLMIEA-KANYYQCHFCDKAFMNQAFLQSHIQRRH---------TEENSH 273

  Fly   183 KDRDKATDVHLINTIKMELEIKQLKERLNAAERNIKERSTGSK-RVSPRQEQRHVGIQSNLAEPK 246
            .:..|...:.     |:..||..|||.|......::.....|. |.|...|.:           |
Human   274 FEYQKNAQIE-----KLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQ-----------K 322

  Fly   247 EKDEDSGEARQSEASERKEQLTGLAERLSNFEEWQTQLKQSNEQFIQDINKRLEGLSHALE-QSK 310
            .|:||..:.......|.||:|.             .::::..|.|:::. |.|...:.||| |..
Human   323 TKEEDFLKLFDRWKEEEKEKLV-------------DEMEKVKEMFMKEF-KELTSKNSALEYQLS 373

  Fly   311 QASASTPPLEDRVAT------------PCLEDLERILTEKVAEIGKVSAHRLEEVVYHLEEGYKE 363
            :...|...::..:.|            |..:|...::....::..|.:|.     |..:.:.:|:
Human   374 EIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTAR-----VQAIHQEHKK 433

  Fly   364 KLGALERELKQLSVQKVQPEPVQTVPVASKIPKPVVRKEETN--IDRIRKQVESEFLKQKHDDDT 426
            :.|.|...:::|....:.......|....:|.:...|.:|.|  |...|:|::         |.|
Human   434 EKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIK---------DFT 489

  Fly   427 YSIEEAPRKGSEKPFPQLVTQVQVVEKEQPSAGSS-DSNPTYTKSP-REPAPNKQETKEA----- 484
            .:    |.....:|            |..|.|..: :|.|.....| ..||.:..|||.:
Human   490 CN----PLNSISEP------------KGNPLAWQAFESQPAAPAVPMNAPALHTLETKSSLPMVH 538

  Fly   485 --------TDVSDSLSQEETENEEERSLTEEEGTDVPTSGSEAAREDPTPKTIKPSGRIIKSPQK 541
                    .:..:.||:||...|.|:.|..              .:....|.:|.:..:.|.
Human   539 EQAFSSHILEPIEELSEEEKGRENEQKLNN--------------NKMHLRKALKSNSSLTKG--- 586

  Fly   542 PLTRKDARKMVNRKLMSH----GFDMKSKGISHNSLKRVNSELTEHRNKLKLQHPHFYATRNRIR 602
                  .|.||.:.||..    |.:...:|||.:.|.||...:...|:|.:.:.|:|:    :||
Human   587 ------LRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFH----QIR 641

  Fly   603 KFVEKLCSAKFSERAEMLLKHKSPLKPMEVPGKG-IPRSAISEKSEEDIASSQGEEQTDEQTDSS 666
            :|:|...|.|..|:| :|...:..:..|:....| :|:.         |.......|...|...|
Human   642 EFLEHQVSCKIEEKA-LLSSDQCSVSQMDTLSTGEVPKM---------IQLPSKNRQLIRQKAVS 696

  Fly   667 EQQTRSPSPQRLVSRD-FKARLEEILVKPAAT---------IRG-ASKSSLSSRPVPLPRKRVMF 720
            ..:|..|..::.|..| |..:...|...|.::         ||. ||...|   |||.|:.:..|
Human   697 TDRTSVPKIKKNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIRAYASPGPL---PVPPPQNKGSF 758

  Fly   721 --NTTE------DGKSFNDSDDNLK 737
              ||.:      :|....|:||:.|
Human   759 GKNTVKSDADGTEGSEIEDTDDSPK 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DZIP1	NP_651263.1	Dzip-like_N	16..133	CDD:433498	26/139 (19%)
		SMC_N	182..>457	CDD:481474	52/290 (18%)
DZIP1	XP_006719979.1	Dzip-like_N	104..224	CDD:433498	29/143 (20%)
		PRK03918	<190..>486	CDD:235175	66/318 (21%)
		C2H2 Zn finger	246..267	CDD:275368	1/20 (5%)