Protein Alignment DZIP1 and DZIP1L

DIOPT Version :10

• Sequence 1: NP_651263.1
• Gene: DZIP1 / 42921
• FlyBaseID: FBgn0039201
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: XP_011510820.1
• Gene: DZIP1L / 199221
• HGNCID: 26551
• Length: 806
• Species: Homo sapiens
• Alignment Length: 740
• Identity: 158/740 - (21%)
• Similarity: 283/740 - (38%)
• Gaps: 210/740 - (28%)

  Fly    16 FKLRQYRDGPLDWRLMGSYETERILREQNFELVDKALTHLSEAPLGTVLETHI---LDSGIAKYF 77
            ||. |.|...:|||.:.:.:.:|:.||.:...:.:.:..::...|...:.:..   :|..:.|..
Human    52 FKF-QPRHDSMDWRRISTLDVDRVARELDVATLQENIAGITFCNLDREVCSRCGQPVDPALLKVL 115

  Fly    78 VMSQYAIQYLMCCRTYLDECVTDLKEAHTTAQEEIATLRKSLSESNNEVVQLHKRITQIEAIRE- 141
            .::|..|:||:.|:..|...|..|:          |.|:.||.:......:|.::..:::.:||
Human   116 RLAQLIIEYLLHCQDCLSASVAQLE----------ARLQTSLGQQQRGQQELGRQADELKGVREE 170

  Fly   142 ---------------------VVYPCHLCTKNFISNEALNVHIGRKHRVASPPSLTSATGKEKDR 185
                                 ..:.||||.|.|::...|..||.|:|      :..:..||:|
Human   171 SRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRH------AGVAEGGKQK-- 227

  Fly   186 DKATDVHLINTIKMELEIKQLKERLNAAERNIKERSTGSKRVSPRQEQRHVGIQSNLAEPKEKDE 250
                        |.|..::::.|.|.|     |.:.|..:..:.|:.:|    |..|.|.:...:
Human   228 ------------KQEQPVEEVLEELRA-----KLKWTQGELEAQREAER----QRQLQEAELIHQ 271

  Fly   251 DSGEARQSEASERKEQ----LTGLAERLSN--FEEWQTQLKQSNEQFIQDINKRLEGL-SHALEQ 308
            ...||:: |..:.|||    |.|..::|..  ::|::...||::     .:.::|..| ||::.:
Human   272 REIEAKK-EFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNS-----TLEEKLRALQSHSVME 330

  Fly   309 SKQASASTPPLEDRVATPCLEDLERI--LTEKVAEIGKVSAHRLEEVVYHLEEGYKEKLGALERE 371
            ||..|     |.|..:...|.....:  |.|| .||.|....|..:.::  ||...||     :|
Human   331 SKLGS-----LRDEESEEWLRQARELQALREK-TEIQKTEWKRKVKELH--EEHMAEK-----KE 382

  Fly   372 LKQLSVQKVQPEPVQTVPVASKIPKPVVRKEETNIDRIRKQVESEFLKQKHDDDTYSIEEAPRKG 436
            |::.: |::|..       .|:..|....:.:..|..:|.|::               |:|....
Human   383 LQEEN-QRLQAS-------LSQDQKKAAAQSQCQISTLRAQLQ---------------EQARIIA 424

  Fly   437 SEKPFPQLVT--QVQVVEKEQPSAGSSDSNPTYTKSPREPAPNKQETKEATDVSDSLSQEETENE 499
            |::...|.::  :|:.:.| .|.|..::.:     ||.|                  ..|::::|
Human   425 SQEEMIQSLSLRKVEGIHK-VPKAVDTEED-----SPEE------------------EMEDSQDE 465

  Fly   500 EERSLTEEEGTDVPTSGSEAAREDPT-PKTIKPSGRIIKSPQKPLTRKDARKMVNRKLMSHGFDM 563
            :.:.|.             |.|.:|| .|..:|   |::.            .:..||.|.|...
Human   466 QHKVLA-------------ALRRNPTLLKHFRP---ILED------------TLEEKLESMGIRK 502

  Fly   564 KSKGISHNSLKRVNSELTEHRNKLKLQHPHFYATRNRIRKFVEKLCSAKFSERAEMLLKHKSPLK 628
            .:||||..:|:.:.|.|...|.:             :.|||.|.|     |.|.:::.:..|..|
Human   503 DAKGISIQTLRHLESLLRVQREQ-------------KARKFSEFL-----SLRGKLVKEVTSRAK 549

  Fly   629 PMEVPGKGIPRSAISEKSEEDIASSQGEEQTDEQTDSSEQQTRSPSPQRLVSRDFKARLEEILVK 693
                           |:.|.....||.:.|...::..|...||...|:   :|..:..|.....:
Human   550 ---------------ERQENGAVVSQPDGQPSVKSQQSTLVTREAQPK---TRTLQVALPSTPAE 596

  Fly   694 PAATIR---GASKSSLSSRPVPLPR 715
            |....|   |:..|||:....|.||
Human   597 PPPPTRQSHGSHGSSLTQVSAPAPR 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DZIP1	NP_651263.1	Dzip-like_N	16..133	CDD:433498	26/119 (22%)
		SMC_N	182..>457	CDD:481474	61/285 (21%)
DZIP1L	XP_011510820.1	Dzip-like_N	52..172	CDD:433498	28/130 (22%)
		PTZ00121	<149..496	CDD:173412	93/469 (20%)