Protein Alignment nAChRalpha1 and CHRFAM7A

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_647536.1
• Gene: CHRFAM7A / 89832
• HGNCID: 15781
• Length: 412
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 151/451 - (33%)
• Similarity: 233/451 - (51%)
• Gaps: 77/451 - (17%)

  Fly   104 EHIWLP---DIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFM 165
            :|:|:.   ||     ||..::.|..|..:::.:|...:.||.|:||.|.|||.:||||.|.|.:
Human    17 QHLWIAANCDI-----ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKL 76

  Fly   166 KFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDI 230
            |||||:|.|:.:||:  .|.|         |:..|..:.|||::.:|..|:|:||.||:|||.|:
Human    77 KFGSWSYGGWSLDLQ--MQEA---------DISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDV 130

  Fly   231 VFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPP 295
            .|.:|:||:||:|.:||:||||.||.|::|||.||:||||||||.|::|||||||.||:|||:|.
Human   131 TFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPA 195

  Fly   296 TSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKK 360
            ||.:|||:.:|...||::|.||||||:.||..:...|...:|..|.:.:.:......|.::||.:
Human   196 TSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE 260

  Fly   361 EEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPP 425
            ::..                                   ||  ..|:....:...:.....|.||
Human   261 DKVR-----------------------------------PA--CQHKQRRCSLASVEMSAVAPPP 288

  Fly   426 LPSSLPLPGADDDLFSPSGLNGDISPGCCP---AAAAAAAADLSPTFEKPYAR---------EME 478
                     |.:......|..|.....|.|   :.........|||.::....         ::.
Human   289 ---------ASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLA 344

  Fly   479 KTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYD 539
            |.:|..|:||...:.:|:.|:|..:||:.|.|:||:.|..|::..::.|..|::.||:..:
Human   345 KILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVE 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	56/140 (40%)
		LIC	27..530	CDD:455710	148/440 (34%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
CHRFAM7A	NP_647536.1	LIC	<28..400	CDD:455710	145/428 (34%)