Protein Alignment nAChRalpha1 and Chrna6

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_476532.2
• Gene: Chrna6 / 81721
• RGDID: 69281
• Length: 493
• Species: Rattus norvegicus
• Alignment Length: 540
• Identity: 223/540 - (41%)
• Similarity: 325/540 - (60%)
• Gaps: 76/540 - (14%)

  Fly     2 GSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNL 66
            |..|:...|:|  |..|.......::|:..|.::|||.||||.|.||.:||...|.::||.:|:.
  Rat    13 GLCLWICGFLA--FFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDE 75

  Fly    67 KNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAIL 131
            .||||.||:|:...|.||:|.|:|.:|.|::||.||:::||.|||||||||.|:::|...|||:|
  Rat    76 VNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALL 140

  Fly   132 HHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG-- 194
            .:.|.:.|.||||:||.|.:|:.:||||.|.|.:||||||||...:||           :.:|
  Rat   141 KYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDL-----------LIIGSK 194

  Fly   195 IDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSV 259
            :|:.|::.:.||:|:.....:::..|:||||.|.||.::..:||..:|||:||||||:.||||:|
  Rat   195 VDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTV 259

  Fly   260 LVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAV 324
            ||||||||.|||::||||:|||||||.|::.|.||.|||.:||:|:||||||:.||||:|||:.|
  Rat   260 LVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFV 324

  Fly   325 LNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERP--KKEEPEEDQPPEVLTDVYHLPPDVDKFVN 387
            ||:::|:|.||.|..||:.:|:|:.|.:|.:.||  |.:|.:..:.|:..|.    .|...||.:
  Rat   325 LNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLDKTKEADGVKDPKTHTK----RPAKVKFTH 385

  Fly   388 YDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPG 452
            ...         |.|....|           ||..                       :.:|:||
  Rat   386 RKE---------PKLLKECR-----------HCHK-----------------------SSEIAPG 407

  Fly   453 ----CCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDR 513
                ..||...|..::..|        ::|..|:..:||.:::|:.::.:.||:||||:|||:||
  Rat   408 KRLSQQPAQWVAENSEHPP--------DVEDVIDSVQFITENMKSHNETKEVEDDWKYMAMVVDR 464

  Fly   514 MFLWIFAIACVVGTALIILQ 533
            :|||:|.|.||.||..:.||
  Rat   465 VFLWVFIIVCVFGTVGLFLQ 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	96/219 (44%)
		LIC	27..530	CDD:455710	215/510 (42%)
		Cys-loop	149..163	CDD:349832	7/13 (54%)
Chrna6	NP_476532.2	LIC	34..483	CDD:455710	215/514 (42%)
		LGIC_ECD	34..240	CDD:475126	96/216 (44%)