Protein Alignment nAChRalpha1 and LOC798522

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_001338964.6
• Gene: LOC798522 / 798522
• -ID: -
• Length: 488
• Species: Danio rerio
• Alignment Length: 546
• Identity: 185/546 - (33%)
• Similarity: 285/546 - (52%)
• Gaps: 80/546 - (14%)

  Fly     1 MGSVLFAAVFI--ALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLID 63
            |..:|.:|:.:  |.|.|.|..|:    :|.:||:.:|:..:|||.:....|.|.:.:.|||:.|
Zfish     8 MEVMLLSALLLAEASHCAQGRFAH----KLLNDLMEDYSSALRPVDDTDKSLNVTLQVTLSQIKD 68

  Fly    64 VNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTK 128
            ::.:||::...:|:.|.|:|..|||:.:||.|::.:.:||..||.||:||||.||.::...:.|.
Zfish    69 MDERNQVLIAYLWIRQVWHDAHLKWSKEDYDGLEVIRIPSSLIWRPDLVLYNKADDDFSGPVDTN 133

  Fly   129 AILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEV 193
            .:|.:||::.|..|||.||.|.:||.|||||.|.|.:.||||||:|..||            |.:
Zfish   134 VVLRYTGEITWDAPAITKSSCVVDVSYFPFDSQQCNLTFGSWTYNGNQVD------------IAM 186

  Fly   194 GI---DLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGIS 255
            |.   ||.|:..:|||:...:||.:|...|.||.:||.||.:.:.|:|::.||.:||::||..||
Zfish   187 GSVSGDLSDFVENVEWECHGMPATKNVIMYGCCSDPYPDITYTVLLQRRSSFYIINLLLPCFLIS 251

  Fly   256 FLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVV 320
            ||:.|.||||:|||||:||.:::||:||||.:::||.:|| |.:|||:.||.:.||.::|.|..:
Zfish   252 FLAPLSFYLPADSGEKVSLGVTVLLALTVFQMMVAESMPP-SESVPLIAKYYIATMTMITASTAL 315

  Fly   321 TIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKF 385
            ||.::|::|.......:..|.:.|.|..:.|:..:    .|..|....|      :....:.:.|
Zfish   316 TIFIMNIHFCGAEAKPVPYWAKVLIIDYMSKIFFV----YEVGESCASP------FGQAEESESF 370

  Fly   386 VNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDIS 450
            .:.:..|            .|:.. ...|.||    ..||       |...:|..||..|
Zfish   371 HSQNHHR------------KHKLH-HPKGKIS----GSPP-------PCCPEDHKSPFVL----- 406

  Fly   451 PGC-----CPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMV 510
             ||     |...:...|.|             .|.:....:||...:.:........:||.||.|
Zfish   407 -GCESCVYCGFRSGNLACD-------------TKLLRNVEYIANCFREQKTTALKVAEWKKVAKV 457

  Fly   511 LDRMFLWIFAIACVVGTALIILQAPS 536
            :||.|:|||.|...:.:.|||.:||:
Zfish   458 MDRFFMWIFFIMVFLMSILIIGKAPT 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	86/220 (39%)
		LIC	27..530	CDD:455710	172/510 (34%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
LOC798522	XP_001338964.6	LGIC_ECD	30..236	CDD:475126	87/221 (39%)
		LIC	32..477	CDD:455710	172/510 (34%)