Protein Alignment nAChRalpha1 and chrna2a

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001035417.1
• Gene: chrna2a / 678575
• ZFINID: ZDB-GENE-040108-2
• Length: 520
• Species: Danio rerio
• Alignment Length: 550
• Identity: 252/550 - (45%)
• Similarity: 331/550 - (60%)
• Gaps: 72/550 - (13%)

  Fly     5 LFAAVFIALH----FATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVN 65
            |:..:.||.|    .:.|.:......:|:..|...||:..|||.|.||.:.||.||.::|||||:
Zfish    13 LWMLILIADHVQPVLSDGWIHAHAEDKLFHKLFIGYNKWSRPVRNISDVVIVKFGLSIAQLIDVD 77

  Fly    66 LKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAI 130
            .|||:||||||::||||||||:|||.::..|.::.||||.||:|||||||||||.:.||.||||.
Zfish    78 EKNQMMTTNVWLKQEWNDYKLRWNPSEFDNVTSIRVPSEMIWVPDIVLYNNADGEFAVTHMTKAH 142

  Fly   131 LHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGI 195
            |.|||||.|.|||||||.|.|||.:||||:|.|.|||||||||...:||         :.||..:
Zfish   143 LFHTGKVSWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDL---------EQIEGTV 198

  Fly   196 DLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVL 260
            ||:||:.|.||.|:......|.|.|.||.|.|.||.:...:||..||||:||||||:.||.|:||
Zfish   199 DLKDYWESGEWAIINAVGTYNTKKYDCCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTVL 263

  Fly   261 VFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVL 325
            |||||||.||||:||||:|||||||.||:.||||.|||.:||:|:||||||:.||||:|:|:.||
Zfish   264 VFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL 328

  Fly   326 NVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKE-EPEEDQPPEVLTDVYHLPPDVDKFVNYD 389
            ||:.|||.||.|..||..:|:..:|:.|.:.||:.| :|::..........:.....||..|..|
Zfish   329 NVHHRSPSTHSMPRWVHSVFLDHIPRWLFMRRPEPEKKPKKTANLSTSKSWFQQETGVDGLVCQD 393

  Fly   390 SKRFSGDYGI--------PALPASH---------RFDLAAAGGISAHCFAEPPLPSSLPLPGADD 437
            .     ::||        |:..:.|         :::|...|.:...|.....|.:.:..||.
Zfish   394 M-----EFGIGLSTSISSPSATSLHLSDSEPLLQKYELQHLGHVVNLCQHPAKLGNLVSEPGL-- 451

  Fly   438 DLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEE 502
             ||||..|                                 :.:||.|:||.|::.:|:..||:|
Zfish   452 -LFSPCVL---------------------------------RALEGVRYIADHLRAEDEDFSVKE 482

  Fly   503 DWKYVAMVLDRMFLWIFAIACVVGTALIIL 532
            ||||||||:||:|||:|.|.|::||..:.|
Zfish   483 DWKYVAMVIDRIFLWMFIIVCLLGTIGLFL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	119/217 (55%)
		LIC	27..530	CDD:455710	246/520 (47%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
chrna2a	NP_001035417.1	LIC	9..513	CDD:455710	251/549 (46%)
		LGIC_ECD_nAChR_A2	37..243	CDD:349816	119/214 (56%)
		Cys-loop	161..175	CDD:349816	9/13 (69%)