Protein Alignment nAChRalpha1 and chrna2b

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_697298.4
• Gene: chrna2b / 568849
• ZFINID: ZDB-GENE-041001-99
• Length: 550
• Species: Danio rerio
• Alignment Length: 550
• Identity: 248/550 - (45%)
• Similarity: 320/550 - (58%)
• Gaps: 90/550 - (16%)

  Fly    28 LYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDD 92
            |:..|...||:..|||.|.||.:.||.||.::|||||:.|||:||||||::||||||||:|.|.|
Zfish    38 LFKKLFDGYNKWSRPVPNTSDVVIVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWKPSD 102

  Fly    93 YGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFP 157
            |..|.::.||||.||:|||||||||||.:.||.||||.|.|||||.|.|||||||.|.|||.:||
Zfish   103 YDNVTSIRVPSELIWVPDIVLYNNADGEFAVTHMTKAHLFHTGKVRWVPPAIYKSSCSIDVTFFP 167

  Fly   158 FDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSC 222
            ||:|.|.|||||||||...:||..::.|         :||:||:.|.||.|:......|.|.|.|
Zfish   168 FDQQNCKMKFGSWTYDKAKIDLERIENT---------VDLKDYWESGEWAIINAVGTYNTKKYDC 223

  Fly   223 CEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFL 287
            |.|.|.||.:...:||..||||:||||||:.||.|:|||||||||.||||:||||:|||||||.|
Zfish   224 CHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLL 288

  Fly   288 LLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKL 352
            |:.||||.|||.:||:|:||||||:.||||:|:|:.||||:.|||.||:|..||..:|:.::|:.
Zfish   289 LITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHKMPCWVHSVFLDLIPRW 353

  Fly   353 LCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAA----- 412
            |.:.||   .|:..:..::|.....:|                  |:.|.||:.....:.
Zfish   354 LFMRRP---APDSRRRQKLLLLQRQVP------------------GMTARPANASLSTSTSWFRG 397

  Fly   413 ----------------------AGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCP 455
                                  :..||....|..|.|..|..|....  |.|:           |
Zfish   398 QNSGEDESCRHFSYKDLELGTLSSAISLSLQASSPCPLGLTPPPLQK--FGPA-----------P 449

  Fly   456 -AAAAAAAADLS-----------------PTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEE 502
             .....|:..||                 |.|  |.:..:.:.:||..:||.|::.:|...||:|
Zfish   450 RLEVGTASRQLSGRANVTKRLDNMIPHDNPGF--PLSPSVLQALEGVHYIADHLRAEDADFSVKE 512

  Fly   503 DWKYVAMVLDRMFLWIFAIACVVGTALIIL 532
            ||||||||:||:|||:|.|.|::||..:.|
Zfish   513 DWKYVAMVIDRIFLWMFIIVCLLGTIGLFL 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	119/213 (56%)
		LIC	27..530	CDD:455710	247/546 (45%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
chrna2b	XP_697298.4	LIC	6..543	CDD:455710	247/549 (45%)
		LGIC_ECD_nAChR_A2	35..241	CDD:349816	119/211 (56%)
		Cys-loop	159..173	CDD:349816	9/13 (69%)