Protein Alignment nAChRalpha1 and LOC5668163

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_001689187.2
• Gene: LOC5668163 / 5668163
• VectorBaseID: AGAMI1_011448
• Length: 442
• Species: Anopheles gambiae
• Alignment Length: 397
• Identity: 89/397 - (22%)
• Similarity: 160/397 - (40%)
• Gaps: 76/397 - (19%)

  Fly    34 SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDV-NLKNQIMTTNVWVE--QEWNDYKLKWNPDDYGG 95
            ::||...|||....|||.:.:|   :::|:| .::|......:.:|  .:|.|..|.||....|.
Mosquito    50 TSYNPRYRPVKYQQDRLAMYIG---AEVINVEKVRNYDSRLEITLELLMQWYDAFLHWNKRTSGN 111

  Fly    96 VDTLHVPSEHIWLPDIVLYNNADG----NYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYF 156
            ::|::|..:.:|.|.....:....    |.:.....|..|.:.|:|::.....:...|..:..|:
Mosquito   112 IETINVAEQDLWTPTFAAKSFQRSPRIQNTKQCTRVKCHLSYDGEVIYTVLCTFTVDCYTEARYW 176

  Fly   157 PFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYS 221
            .||.:.|.::..|..||...:.|.|.::.....:    ..|..|.|: .:.:..|.:..:.:|
Mosquito   177 AFDTKICTLRIYSVEYDTNQLSLFHFQRRLSYPS----YSLLPYKIT-SFQMATVNSTMSPEF-- 234

  Fly   222 CCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTV-- 284
                 .:|||....:....:.:.|.:::.|    ||::...:...|:..:   .|:::|...:
Mosquito   235 -----RMDIVIERLVGSHLVVFLVLIVMFC----FLNLFSLWFSIDTSAR---TIAVVLGTVMQG 287

  Fly   285 FFLL------LAEIIPPTSLTVPLLGKYLL---------FTMMLVT---------LSVVVTIAVL 325
            .||:      :.::.|..:|...|||.:.|         :....:|         |:|:.||:.|
Mosquito   288 MFLVILYWYGMVKMKPVITLAHLLLGSFALGVIAFGWTYYARGQITSRKGCTECPLAVIQTISCL 352

  Fly   326 NVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKE--EPE-EDQPPEV--LTDVYHLPPDVD-- 383
            ..|         .|....|.|..|...:     ||:  .|| ||..||.  .|.|.:||.|.|
Mosquito   353 RKN---------RPLTSFLSIGYLNGSI-----KKDTLSPEWEDNLPEANRQTQVRNLPQDDDTA 403

  Fly   384 KFVNYDS 390
            ...|.||
Mosquito   404 STTNDDS 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	46/214 (21%)
		LIC	27..530	CDD:455710	89/397 (22%)
		Cys-loop	149..163	CDD:349832	4/13 (31%)
LOC5668163	XP_001689187.2	None