Protein Alignment nAChRalpha1 and chrna11

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001038562.1
• Gene: chrna11 / 566141
• ZFINID: ZDB-GENE-060503-606
• Length: 589
• Species: Danio rerio
• Alignment Length: 615
• Identity: 202/615 - (32%)
• Similarity: 311/615 - (50%)
• Gaps: 123/615 - (20%)

  Fly    12 ALHFATGGLA--------NPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKN 68
            :|.|...|::        .|..:.|..:||.:|||:.|||.|:|..|||.:.:.|.|::||:.||
Zfish     4 SLAFTLCGISALIQVSVQGPYQRTLLKNLLKDYNRMERPVANDSQPLTVFLSMSLIQIMDVDEKN 68

  Fly    69 QIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHH 133
            |::|||:|:...|.|:.|:||..:|.||..|...::.:|.|||:|||:||..::.|..:..:::.
Zfish    69 QVLTTNIWLNMHWYDHYLQWNQSEYPGVKNLRFTTDQVWTPDILLYNSADDKFDSTFKSNVVVNS 133

  Fly   134 TGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQ 198
            :|...:.||.|:.|.|.:||.:||||.|.|.:||||||:||:::||:..:           .|:.
Zfish   134 SGYCNYLPPGIFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDLQMNE-----------ADIS 187

  Fly   199 DYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFY 263
            .|..:.|||::.||..|||.||.||:|||.|:.|.:|:||:||:|.:||:||||.:|.:::|:|.
Zfish   188 GYMPNGEWDLVGVPGTRNELFYDCCKEPYPDVTFVVTIRRRTLYYALNLLIPCVLLSSMTLLIFL 252

  Fly   264 LPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVN 328
            ||:||||||||.|::|||||||.||:|||:|.||.::||:|:|....|::|.:||:.|:.||..:
Zfish   253 LPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSIPLIGQYFASIMIIVGMSVIATVVVLQYH 317

  Fly   329 FRSPVTHRMAPWVQRLFIQILPKLLCIERP-KKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKR 392
            ...|....|..|||.:.:|.:...|.::|| :.|:||.             ||.........|..
Zfish   318 HHDPNGGNMPKWVQLVLLQWVAWFLRMKRPGESEDPER-------------PPCAPHLRRCSSGS 369

  Fly   393 FSGDYGIPALPASHRFDL--------------------AAAGGISAH------------------ 419
            .||  .:|..|.|...||                    |||.|.:.|
Zfish   370 QSG--SLPNAPGSASADLHHHHISSTLHPLHPQSLLQAAAAAGHTHHLHNQTNSANNNGNLLYIG 432

  Fly   420 ----------------------------CFAEPPLPSSLPLPGADDDLFSP----------SGLN 446
                                        ....||:..|.|.|.......||          :|..
Zfish   433 FSSLDEASPPALLADSVQRNSMSGGPRPTVVSPPVVGSSPPPHLPSQFCSPPPPPTPNLEATGCP 497

  Fly   447 GDIS--PGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAM 509
            ..:|  .|.|..:..:...|          .:::..:|..|::|...:.:|:.|||.|.||:.|.
Zfish   498 STVSGGGGGCSCSGTSGGGD----------PQLQAILEEVRYVADRFRGQDENESVTEQWKFAAA 552

  Fly   510 VLDRMFLWIFAIACVVGTALIILQAPSLYD 539
            |:||:.|..|::..::.|..|::.||:..:
Zfish   553 VIDRLCLVAFSVFNIICTISILMSAPNFVE 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	91/217 (42%)
		LIC	27..530	CDD:455710	195/581 (34%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
chrna11	NP_001038562.1	LIC	2..577	CDD:455710	200/608 (33%)