Protein Alignment nAChRalpha1 and CHRNA9

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_060051.2
• Gene: CHRNA9 / 55584
• HGNCID: 14079
• Length: 479
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 191/543 - (35%)
• Similarity: 284/543 - (52%)
• Gaps: 92/543 - (16%)

  Fly    10 FIALHFATGGLANPD------AKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKN 68
            |..::||...|...:      |::|::||..:|:..:|||.:....|.|.:.:.|||:.|::.:|
Human    10 FCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERN 74

  Fly    69 QIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHH 133
            ||:|..:|:.|.|:|..|.|:.|.|.|:|::.:||:.:|.|||||||.||......:.|..:|.:
Human    75 QILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRY 139

  Fly   134 TGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQ 198
            .|.:.|..|||.||.|.:||.|||||.|.|.:.||||||:|..||:.:   ..||.      ||.
Human   140 DGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFN---ALDSG------DLS 195

  Fly   199 DYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFY 263
            |:...|||::..:|||:|...|.||.|||.|:.|.|.|:|::.||.|||:||||.||||:.|.||
Human   196 DFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFY 260

  Fly   264 LPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVN 328
            ||:.||||:||.::|||::|||.|::|||: |.|..|||:|||.:.||.|:|.|..:||.|:|::
Human   261 LPAASGEKVSLGVTILLAMTVFQLMVAEIM-PASENVPLIGKYYIATMALITASTALTIMVMNIH 324

  Fly   329 F----RSPVTHRMAPWVQRLFIQILPKLL--------CIERPKKEEPEEDQPPEVLTDVYHLPPD 381
            |    ..||.|    |.:.:.::.:.::|        |:      .|...:..:.||.||...|:
Human   325 FCGAEARPVPH----WARVVILKYMSRVLFVYDVGESCL------SPHHSRERDHLTKVYSKLPE 379

  Fly   382 VDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLN 446
            .:                  |.|:...||:....::..                         |.
Human   380 SN------------------LKAARNKDLSRKKDMNKR-------------------------LK 401

  Fly   447 GDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVL 511
            .|:  ||         ...:|...:.|..:.:.......:||:.:|:.....|...:||.||.|:
Human   402 NDL--GC---------QGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVI 455

  Fly   512 DRMFLWIFAIACVVGTALIILQA 534
            ||.|:|||.|...|.|.|||.:|
Human   456 DRFFMWIFFIMVFVMTILIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	91/223 (41%)
		LIC	27..530	CDD:455710	182/514 (35%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
CHRNA9	NP_060051.2	LIC	10..474	CDD:455710	187/537 (35%)
		LGIC_ECD_nAChR_A9	31..237	CDD:349823	91/214 (43%)
		Cys-loop	155..169	CDD:349823	9/13 (69%)