Protein Alignment nAChRalpha1 and LOC4577940

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_061513781.1
• Gene: LOC4577940 / 4577940
• VectorBaseID: AGAMI1_009486
• Length: 442
• Species: Anopheles gambiae
• Alignment Length: 384
• Identity: 80/384 - (20%)
• Similarity: 159/384 - (41%)
• Gaps: 57/384 - (14%)

  Fly     3 SVLFAAVFIALHFATGGLANPDAKR------LYDDLLSN-YNRLIRPVGNNSDRLTVKMGLRLSQ 60
            |.::..:.:|..|.:....|.|.||      :...|..| |:..|||..:..|.:.:.....|..
Mosquito     6 SFIYLPLLVAFLFDSASSINCDKKRDNVQYTIKQHLFCNGYDPKIRPAKSEFDSINITTYAVLYS 70

  Fly    61 LIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYE--- 122
             .|::....:|:..|.....|.|..|.|:..|:..:.||::.::.||.|.   :.|.:.:||
Mosquito    71 -FDISEYRSVMSLQVNYYMHWQDSSLAWDASDWSNITTLNINNDEIWSPQ---FENINSDYEGQP 131

  Fly   123 -VTIMT-KAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQT 185
             |:.:: ..:||..|.:...|.....:.|..|...:||:...|.|.|           ....|:.
Mosquito   132 SVSCLSPDCLLHEDGGISCSPVCRISAKCSSDYTRWPFNTLVCRMWF-----------TNRDKEL 185

  Fly   186 ADSDN---IEVGIDLQDYYISVEWDIMRVPAVRNE-KFYSCCEEPYLDIVFNLTLRRKTLFYTVN 246
            .|..|   :...:....:..:.:|.:..|.:.:.: ...........::.|||   ..:...|:.
Mosquito   186 VDEVNFLPVITYLPSNHHLPTTKWCVTSVSSNKTQLSIPGATSRTVEELEFNL---EHSPHLTIA 247

  Fly   247 LI-IPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFT 310
            :| :|...:|.|::.|..|.|...|||   :..|:.:...|.||.::..||. .:|.:..:::.:
Mosquito   248 IIYLPAFALSMLNMFVCLLDSRVKEKI---VIPLICMVFHFQLLQQMRNPTP-EIPGVVLFIIAS 308

  Fly   311 MMLVTLSVVVT---------------IAVLNVNFRSPVTHRMAPWVQRL-FIQILPKLL 353
            |:|..|..|:|               ||:.::  |:.::.|:..|:.:: ::.:..|::
Mosquito   309 MILTFLLFVITLINRWLHDLQSTPPNIAIRSM--RAILSSRVMNWILKVDYLSVGQKVM 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	47/233 (20%)
		LIC	27..530	CDD:455710	74/360 (21%)
		Cys-loop	149..163	CDD:349832	4/13 (31%)
LOC4577940	XP_061513781.1	None