Protein Alignment nAChRalpha1 and pHCl-2

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 343
• Identity: 77/343 - (22%)
• Similarity: 143/343 - (41%)
• Gaps: 73/343 - (21%)

  Fly    20 LANPDAKRLYDDLLS------NYNRLIRPVGNNSDRLTVKMGL--RLSQLIDVNLKNQIM--TTN 74
            |.|.::..|. :||:      .|:|::.||.:|.|...|.|.:  |....:..||.:..:  |..
  Fly    64 LKNAESMALM-ELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQ 127

  Fly    75 VWVEQEWNDYKLKWNPDDYGGVDTLHVPSEH------------IWLPDIVLYN-------NADGN 120
            ..::..:.|.:|.::.         ::|:..            :|:|.|.|.|       .....
  Fly   128 GLLQLRYLDPRLAFSS---------YLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAK 183

  Fly   121 YEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQT 185
            .|:|     .::..|.|:.........:|.::.:.||||||.|.....||.|:..:|.|..  :|
  Fly   184 DELT-----SIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHW--ET 241

  Fly   186 ADSDNIEVGIDLQDYYI--SVEWDIMRVPAVRNEKFYS--CCEEPYLDIVFNLTLRRKTLFYTVN 246
            .:..:.:..:.|.:|.:  |:..:.:|   |.||.:.|  ..|..|..|.|.:.|.|:..:|.::
  Fly   242 DNPVSFDKQLQLTEYNLIGSLYNESIR---VSNESYMSHGSLEGNYSIISFTVLLTREVGYYVID 303

  Fly   247 LIIPCVGISFLSVLVFYLPSD-SGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFT 310
            ..:|.:.|..:|.:.|:|.:| :..:.:|..:.|||.               :|:.|..:..|..
  Fly   304 YFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSF---------------ITLSLSQENNLMK 353

  Fly   311 MMLVTLS----VVVTIAV 324
            :..||:|    :|.||.:
  Fly   354 VSYVTMSEVWFLVCTIFI 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	55/250 (22%)
		LIC	27..530	CDD:455710	75/336 (22%)
		Cys-loop	149..163	CDD:349832	7/13 (54%)
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	77/343 (22%)