Protein Alignment nAChRalpha1 and nAChRalpha2

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 321/568 - (56%)
• Similarity: 397/568 - (69%)
• Gaps: 67/568 - (11%)

  Fly    21 ANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYK 85
            |||||||||||||||||||||||.||:|.:.||:|||||||||:|||:||:|||||:|.||.|:|
  Fly    41 ANPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHK 105

  Fly    86 LKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCE 150
            .||:|.:||||..|:|||||||||||||||||||.|.||.|||||||:||||||.||||:||.||
  Fly   106 FKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAILHYTGKVVWTPPAIFKSSCE 170

  Fly   151 IDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDN-IEVGIDLQDYYISVEWDIMRVPAV 214
            |||.|||||:||||||||||||||..:||:|:.|..|.|| :|:||||::||.||||||:.|||.
  Fly   171 IDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAE 235

  Fly   215 RNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISIL 279
            |:||:|.||.|||.||.||:|||||||||||||||||||||:|||||||||:||||||:||||||
  Fly   236 RHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPADSGEKIALCISIL 300

  Fly   280 LSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRL 344
            ||.|:||||::||||.|||.:|||||||||||:||.||||:||.:||:::|.|.||:|.||::..
  Fly   301 LSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSF 365

  Fly   345 FIQILPKLLCIERPKKEEPEEDQPPEVLTDV------YHLPPDVDKF--------------VNYD 389
            ||:.|||||.:..||          ::|.|:      |.|.....||              .:.|
  Fly   366 FIKRLPKLLLMRVPK----------DLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPD 420

  Fly   390 SKR-------FSGDYGIPALPASHRFD--LAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGL 445
            |.|       ..|..|:....|::||.  :.|.||..:.......|||  .|.|.||.|
  Fly   421 SLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPS--VLSGLDDSL------ 477

  Fly   446 NGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMV 510
             .|::.                  .|.|..|:||.|....||..|::.:|:|.:.::||.:||||
  Fly   478 -SDVAA------------------RKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMV 523

  Fly   511 LDRMFLWIFAIACVVGTALIILQAPSLYDQSQPIDILYSKIAKKKFEL 558
            :||:|||:|.||.:|||.:|:.:||||||.::.||:..|.:||:.:.|
  Fly   524 MDRLFLWLFMIASLVGTFVILGEAPSLYDDTKAIDVQLSDVAKQIYNL 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	164/218 (75%)
		LIC	27..530	CDD:455710	302/532 (57%)
		Cys-loop	149..163	CDD:349832	11/13 (85%)
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	164/218 (75%)
		LIC	47..544	CDD:455710	302/533 (57%)
		Cys-loop	169..183	CDD:349832	11/13 (85%)